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Design of Microfluidic Device for Cellular Experiment Under Controlled Oxygen Tension


K. Funamoto1 I.K. Zervantonakis2 R.D. Kamm2
1Tohoku University, Sendai City, Miyagi, Japan
2Massachusetts Institute of Technology


Steady oxygen tension on a cross-section of a microfluidic device with oxygen barrier film.

Numerical simulation of oxygen tension was performed to develop a microfluidic device for three-dimensional real-time observation of cellular response under hypoxia. The optimal experimental condition was obtained through investigations of effects of parameters, such as device thickness and flow rates of media and gas, on oxygen tension.

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