Deformable Image Registration for Pleural Photodynamic TherapyB. Liu, T. C. Zhu
Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Deformable image registration is a form of medical image processing that can provide insights into the development of phenomenon and variation in normal anatomical structure over time. Prior to post-operative pleural photodynamic therapy (PDT), a series of CT scans of lungs will be acquired. During PDT treatment, an infrared navigation system is used to contour the lungs and provide real-time treatment guidance. Image segmentation is performed to differentiate different tissue types such as bone, connective tissue, organs, and air in the lung. The lung will be contoured via gradient edge-detection, then converted into solid geometries and imported to COMSOL Multiphysics®. The results of the deformable image registration performed for five patients will be presented and discussed in this work in the near future.