Effects of Flow and Diffusion on Blood Coagulation in Platelet Poor Plasma: a Two-way Coupling Between Hemodynamics and Biochemistry

D. Magnabosco[1,2], H. van Ooijen[2], B. Bakker[2], R. van den Ham[2]
[1]Politecnico di Milano, Milan, Italy
[2]Philips Research, Eindhoven, The Netherlands

Enzyme reactions, blood flow and diffusion in human vasculature play interacting and fundamental roles in blood coagulation. In this complex mechanism, the balance between blood and clot is a delicate equilibrium, whose tight regulation is vital to avoid pathologies such as bleeding and thrombosis. The secondary hemostasis triggered by tissue factor in platelet poor plasma is studied up to fibrin production and thrombus formation. The effect of both hemodynamic and chemical factors is investigated to understand their impact on the coagulation burst and the clot development.