Finding Optimal Operating Conditions for SMB-Plants using COMSOL

M. Fütterer
Institut für Automatisierungstechnik, Otto von Guericke Universit├Ąt, Magdeburg, Germany

Simulated moving bed (SMB) chromatography is a commonly used separation technology. It consists of chromatographic columns that are interconnected to a ring. The feedings and drains are changed cyclically so that a continuous separation is maintained.

To find optimal operating conditions, the triangle theory is often used. This theory is based on a true moving bed (TMB). Therefore, it will only give a rough estimation that can be used as an initial guess for a dynamic optimization.

This paper will show that the optimized switching time depends heavily on the desired purity. The result shows that a significant reduction of the solvent is possible.