Fluid Dynamics of Blood Flow During Reperfusion and Post-conditioning

T. Merrill, and A. La Barck
Rowan University, Glassboro, NJ, USA

Reperfusion injury is caused by the rapid restoration of blood flow to oxygen-starved tissue. The model will simulate pulsatile blood flow. A separate 2-dimensional axisymmetric straight tube model will be constructed to simulate the pulsating angioplasty balloon within the flow path. Outlet flow profiles from the straight tube model will then be used as the inlet condition for the 3-dimensional coronary artery model.

Both steady and pulsatile flow will be modeled. The motion of the balloon will be simulated with a logical expression for the viscosity. After solving for the fluid flow around the balloon, the outlet velocity profiles and flow rates can be used as inlet conditions for the left coronary artery model. The Transport of Diluted Species Interface will be used to model convective and diffusive biochemical species transport within the arteries.

COMSOL Multiphysics to fluid and transport modelling will lay the foundation for understanding the protective effects of postconditioning.