Modeling High Gradient Magnetic Separation from Biological Fluids

D. Bockenfeld[1], H. Chen[2,5], D. Rempfer[1], M.D. Kaminski[4], and A.J. Rosengart[2,3]
[1] Department of Mechanical, Material and Aerospace Engineering, Illinois Institute of Technology
[2] Department of Neurology, The University of Chicago and Pritzker School of Medicine
[3] Department of Surgery (Neurosurgery), The University of Chicago and Pritzker School of Medicine
[4] Chemical Engineering Division, Argonne National Laboratory
[5] Department of Biomedical Engineering, Illinois Institute of Technology

A proposed portable magnetic separator consists of an array of biocompatible capillary tubing and magnetizable wires immersed in an externally applied homogeneous magnetic field. While subject to the homogeneous magnetic field, the wires create high magnetic field gradients, which aid in the collection of blood-borne magnetic nanospheres from blood flow.

In this study, a 3-D numerical model was created using COMSOL Multiphysics 3.2 to optimize the configuration of the wire-tubing array comparing two possible configurations.

The results demonstrate that one of the configurations would actually capture more of the magnetic spheres. Experimental data obtained by our group support this numerical result.

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