Modeling of Singlet Oxygen during Photodynamic Therapy using COMSOL

T.C. Zhu, J.C. Finlay, X. Zhou, and J. Li
Department of Radiation Oncology, University of Pennsylvania

Photodynamic therapy is a new cancer treatment modality based on the interaction of light, photosensitizers, and oxygen. Yet, when the concentration of the singlet oxygen exceeds a certain threshold in a cell, irreversible apoptosis or necrosis occurs.

The time dependences of the concentrations were obtained for the photosensitizer and intracellular receptors using the COMSOL Reaction Engineering Lab. We have derived the relationship between the dependence of the photosensitizer and receptor decay times on the drug concentration and total light fluence.