Multiphysic Modeling of the Self-sustained Anisotropic Contraction of Cardiac MyocytesP. Tracqui, and J. Ohayon
CNRS, Laboratoire TIMC-IMAG, Equipe DynaCell, La Tronche, France
In this work, we coupled intracellular calcium wave propagation to anisotropic active cellular contraction in order to investigate the self-oscillating contractions of isolated cardiac myocytes.
The autocatalytic release of Ca2+ from intracellular stores is considered as the corner stone of a biochemical model exhibiting relaxation oscillations above critical thresholds of calcium fluxes.
Using COMSOL Multiphysics, we additionally implemented a hyperelastic description of the myocyte mechanical behavior, which integrates an active strain energy function.
The finite element simulations of the periodic shortening of the cardiomyocytes compare very well to the self-sustained contractions of isolated rat cardiomyocytes recorded by time-lapse videomicroscopy.