Multiphysics Simulation of Isoelectric Point Separation of Proteins Using Non-Gel Microfluidic System

A. Contractor[1], N. Xue[2], J.B.Lee[2], A. Balasubramanian[1], and G. Hughes[1]
[1]Lynntech, Inc., College Station, Texas, USA
[2]Micro Nano Devices and Systems (MiNDS) Laboratory, Department of Electrical Engineering, University of Texas at Dallas, Texas, USA

A portable device that can identify protein and peptides real time in complex biological systems such as human bodily fluids reliably and accurately is in high demand to properly diagnose and treat medical conditions. Lynntech has developed an innovative Polydimethylsiloxane (PDMS) based microfluidics system with a unique design utilizing multi-channel inlets and outlets for isoelectric point (pI) based separation of proteins. The design of the microfluidics chip is optimized by performing numerical simulations using COMSOL Multiphysics.