Reducing Mitigating Factors That Lead to Clotting of the Arteries From Prolonged Hemodialysis

K. Hegde[1], J. Clark[1], A.G. Akingba[2], and J.V. Clark[1]
[1]Purdue University, West Lafayette, IN, USA,
[2]Indiana University, Indianapolis, IN, USA

In this paper we present a computational study of our novel arteriovenous (AV)-shunt interface device that is expected to reduce the mitigating factors that lead to clotting of the AV-shunts from prolonged hemodialysis. Kidney failure affects about 300,000 (about 0.1%) of the United States population. About 20% of the hemodialysis hospitalizations in the U.S. are due to clotting-related vascular access failure, which amounts to a yearly cost of about $1 billion. What is new and different about our technology is that our device incorporates protective and hemodynamic benefits at the artery-shunt interface, which reduces turbulence and stagnation to promote laminar flow. Our device also provides a cap to seal the arterial anastomosis after device implantation, which is expected to eliminate the need for suturing. In our computational study, we compare conventional shunt-artery interfaces against our novel interface in terms of laminar flow, stagnation, sidewall pressure, strain, and shear.