Reducing Mitigating Factors That Lead to Clotting of the Arteries From Prolonged HemodialysisK. Hegde, J. Clark, A.G. Akingba, and J.V. Clark
Purdue University, West Lafayette, IN, USA,
Indiana University, Indianapolis, IN, USA
In this paper we present a computational study of our novel arteriovenous (AV)-shunt interface device that is expected to reduce the mitigating factors that lead to clotting of the AV-shunts from prolonged hemodialysis. Kidney failure affects about 300,000 (about 0.1%) of the United States population. About 20% of the hemodialysis hospitalizations in the U.S. are due to clotting-related vascular access failure, which amounts to a yearly cost of about $1 billion. What is new and different about our technology is that our device incorporates protective and hemodynamic benefits at the artery-shunt interface, which reduces turbulence and stagnation to promote laminar flow. Our device also provides a cap to seal the arterial anastomosis after device implantation, which is expected to eliminate the need for suturing. In our computational study, we compare conventional shunt-artery interfaces against our novel interface in terms of laminar flow, stagnation, sidewall pressure, strain, and shear.