COMSOL Multiphysics® as a Tool for Reducing Animals in Biomedical Research: An Application in Dermatology
F. Rossi and R. Pini
Istituto di Fisica Applicata “Nello Carrara”, Consiglio Nazionale delle Ricerche, Firenze, Italy
In biomedical research the use of animal models gives rise to several ethical problems. COMSOL Multiphysics® may be used as a non-animal technique, very useful in overcoming all these concerns. In this presentation a particular application in dermatology is shown. Bioheat equation mode and diffusion approximation were used to design a theoretical model of blue LED light interaction with an ...
Q.A. Chaudhry, M. Hanke, and R. Morgenstern
School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden
Karolinska Institutet, Stockholm, Sweden
The mathematical modeling of the diffusion and reaction of toxic compounds in mammalian cells is tough task due to their very complex geometry. The heterogeneity of the cell, particularly the cytoplasm, and the variation of the cellular architecture, greatly affects the behavior of these toxic compounds. Homogenization techniques have been implemented for the numerical treatment of the model. ...
C. Heining and N. Aksel
Applied Mechanics and Fluid Dynamics, University of Bayreuth, Bayreuth, Germany
We study the gravity-driven film flow of a Newtonian liquid down an inclined plane. Many applications such as heat- and mass exchangers and evaporators or film coaters require undulated or rippled bottom topographies. In these cases, the interplay of gravity, surface tension and inertia leads to a response of the interface which furthermore strongly depends on the shape of the bottom topography. ...
Chief Technology Officer, COMSOL
Ed Fontes is CTO at COMSOL with specific interest in the transport-reaction products. He has 14 years experience of modeling transport phenomena in industry and 6 years of supervising research projects in Academia. Ed Fontes received his PhD in Electrochemical Engineering from the Royal Institute of Technology (Stockholm, Sweden) in 1995.
F. Lugli and F. Zerbetto
Department of Chemistry “G. Ciamician”, Università di Bologna, Bologna, Italy
A small particle or a nano-sized object placed in a liquid is subject to random collisions with solvent molecules. The resulting erratic movement of the object is known as Brownian motion, which, in nature, cannot be used to any practical advantage both in natural systems (such as biomolecular motors) or by artificial devices. If energy is supplied by external source or by chemical reactions, ...
E. Sparacino, D. Madeo, and C. Mocenni
Dipartimento di Ingegneria dell’Informazione, Università di Siena, Siena, Italy
This work concerns the development of a new direct parameter identification procedure for a class of nonlinear reaction- diffusion equations. We assume to know the model equations with the exception of a set of constant parameters, such as diffusivity or reaction term parameters. Using the Finite Element Method we are able to transform the original partial differential equation into a set of ...
P. Cendula, S. Kiravittaya, J. Gabel, and O.G. Schmidt
Institute for Integrative Nanosciences, Dresden, Germany
Strained wrinkled and flat nanomembranes have different bending properties when they are released from the underlying substrate. This is caused by increased bending rigidity of the wrinkled film in one direction. We provide theoretical and numerical analysis of the directional rolling of wrinkled films, which is important for positioning rolled-up tubes on the short mesa edge during fabrication.
R. Winz, N. Schröder, W. Wiechert, and E. von Lieres
Institute of Biotechnology 2, Research Centre Jülich, Jülich, Germany
Research Center for Micro and Nanochemistry, University of Siegen, Siegen, Germany
In recent years lab-on-microchip technology has become a powerful tool for micro-scale analysis of biochemical processes. In the studied system the overall process consists of transport, convection, diffusion, reaction and adsorption processes. Two compounds A and B, contained in a carrier fluid (buffer), are introduced into a reaction channel via a Y-shaped double-inlet. As the streams flow ...
Filip Van den Abeele
Simulation Expert, OCAS, Belgium
OCAS is a joint venture between ArcelorMittal and the Flemish Region. She uses COMSOL Multiphysics for the following: Enamel solidification Magnetic Pulse Forming Electromagnetic modelling of electric machines Vortex Induced Vibrations Model Identification for Orthotropic Materials and much more ---------------------------------- Keynote speaker's biography:Filip Van den Abeele has a ...
F. Tondini, P. Bosetti, and S. Bruschi
DIMS, University of Trento, Trento, Italy
The hot stamping of boron steels for producing complex structural components of the car body-in-white is more and more widespread. Optimization of sheet forming technologies at elevated temperatures is still troublesome, since the thermal, mechanical and metallurgical phenomena interacting during hot stamping force to feed the numerical model of the process by a huge amount of data, most of which ...