A. Heidsieck, and B. Gleich
Zentralinstitut für Medizintechnik, TU München, München, Germany
The technique of magnetic drug targeting binds genetic material or drugs to superparamagnetic nanoparticles and accumulates them via an external magnetic field in a target region. However, it is still a challenge for this approach to succeed in areas with high flow rates, like the aorta or the heart ventricle. The magnetic field sources have to be accurately optimized and adapted to the local ...
S. Gerbino, and P. Franciosa
University of Molise, School of Engineering, Via Duca degli Abruzzi, Termoli, Italy
Understanding the stress-strain behavior of human foot tissues and pressure map distributions at the plantar interface is of interest into biomechanical investigations. In particular, monitoring plantar pressure maps is crucial to establishing the perceived human comfort of shoe insoles. A 3D anatomical detailed FE human foot model was created, starting from CT (Computer Tomography) scans of a ...
J.J. Dubowski, and D.Carrier
Department of Electrical and Computer Engineering, Université de Sherbrooke, Quebec, Canada
We present a Finite Element Method simulation procedure that allows rapid development of prototype devices comprising novel self-referenced interference SPR (surface plasmon resonance) biosensing microstructures. The procedure takes advantage of COMSOL Multiphysics and MATLAB software and their bi-directional link. The simulation is made using COMSOL RF Module, 2D harmonic propagation ...
H. Esfandyarpour1,2, A. Maiyegun1, and R. W. Davis2
1Center for Integrated Systems, Department of Electrical Engineering, Stanford University, Stanford, CA, USA
2Stanford Genome Technology Center, Stanford, CA, USA
We present a preliminary investigation of a Nanoneedle biosensor as an ultra sensitive and localized impedance biosensor using COMSOL.This preliminary study was performed to prove the feasibility of the impedance biosensor for detection of protein or nucleic acids. By monitoring the change in capacitance and impedance of this structure, we aim to characterize and classify biological species such ...
Numerical Investigation of a Time-dependent Magnetic Actuation Technique for Tagging Biomolecules with Magnetic Nanoparticles in a Microfluidic System
A. Munir, J. Wang, Z. Zhu, and H.S. Zhou
Worcester Polytechnic Institute, Worcester, MA, USA
The magnetic body forces that act on mono-dispersed magnetic nanoparticles (MNPs) tagged biomolecules in a microfluidic system can be efficiently used in various applications that involve separation and detection including DNA and protein analysis, bio-defense, drug delivery, and pharmaceutical development. In this work, we report an FEM model to demonstrate a novel method of tagging biomolecules ...
T. Shazly, and J. Ferdous
Biomedical Eng., Mechanical Eng. Dept.
University of South Carolina
Erodible polymeric scaffolds can mitigate long-term risks associated with permanent implants currently used to treat ischemic artery disease. However, safe deployment of erodible scaffolds is predicated on understanding the interactions between evolved material by-products and local biological tissues. We developed an integrated computational model of polymeric scaffold degradation, by-product ...
K. Manda, and A. Eriksson
Royal Institute of Technology
100 44 Stockholm, Sweden
Articular cartilage is an avascular connective soft tissue in the diarthrodial joints and functions in a highly demanding mechanical environment. The degeneration or wear of the cartilage is a huge problem that effects millions of people every year. The long term objective of the present work is to develop an analytical articular cartilage growth model. A simplified 2D axisymmetric ...
P. Pattanaik, S. K. Kamilla, D. P. Das, S. K. Pradhan
MEMS Design Center, Institute of Technical Education & Research (ITER), Sikhya ‘O’ Anushandhan University, Bhubaneswar, Odisha, India
Process Engineering and Instrumentation Lab, Institute of Minerals and Materials Technology (IMMT), Bhubaneswar, Odisha, India
Dept of ECE, Hi-Tech Institute of Technology, Khurda, Odisha, India
This paper describes the design of an ultrasonic transducer using different lead free piezo-electric materials and evaluates their performance with different glucose levels in the human blood. COMSOL Multiphysics 4.2a was used for the simulation study using 2D axis symmetric model of piezoelectric transducer which was designed with lead free piezoelectric materials such as Barium Sodium Niobate ...
E. Isaza, E. Salazar, L. Florez
Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia
The consequences of hip fracture and femoral fracture are widely known. The mechanical strength of the femur varies in every person, but it is possible to predict the mechanical resistance with parameters like density, dimensions and mineral content. This paper uses different models and empirical studies to determine the mechanical properties of the human femur, developing isotropic and ...
J. C. Kumaradas, A. Zhang, Y. D. Davletshin
Ryerson University, Toronto, ON, Canada
University of Waterloo, Waterloo, ON, Canada
Tremendous progress is being made in the integration of nanoparticles into micro-analytical systems for biosensing. These materials are shown to enhance the analyte capture capability of biosensing platforms. We have implemented a computational model that considers the sensor’s geometry, size, analyte concentration and type to predict the number of nucleic acid molecules captured by ...