A. Sun, and S. Murray
Dept. of Biomedical Engineering
UCLA, Los Angeles, CA
Implantable Collagen sponges are used in Spinal Surgery as Drug Delivery Scaffolds. An optimal concentration of growth factor that strikes a balance between bone growth and adverse diffusion effects is difficult to find. The porous sponge also serves as a scaffold for Osteoblast growth, and fluid shear has been shown to mediate biological effects on that cell type. We use COMSOL Multiphysics ...
S. Raveendran, S. Sukuvihar, S. Kumar, and T. Maekawa
• Bionanotechnology is a stream of modern science that deals with the study of biotechnology & nanotechnology applications. • Drug delivery applications as a key area of research attains more critical approaches where the role of nanoparticles are inevitable. • Biocompatible, non-cytotoxic hybrid mauran- chitosan nanoparticles has been synthesized and the drug release kinetics were ...
Image-based Simulation of Electrical Impedance Techniques Applied on the Human Thorax for Cardio-pulmonary Applications
A. Harkara, R.M. Heethaar, R.T. Cotton, and F.K. Hermans
Simpleware Ltd., Exeter, UK
VU University Medical Center, Amsterdam, Netherlands
For medical diagnostic purposes there is an increasing need for non-(or minimal) invasive techniques to measure all kinds of parameters that can provide insight in the functioning of cells, organs or organ systems. Currently, Impedance Cardiography (ICG) is used for measurements of the heart and Electric Impedance Tomography (EIT) is used for investigating lung tissue condition. The PDE is ...
P. Pattanaik, S. K. Kamilla, D. P. Das, S. K. Pradhan
MEMS Design Center, Institute of Technical Education & Research (ITER), Sikhya ‘O’ Anushandhan University, Bhubaneswar, Odisha, India
Process Engineering and Instrumentation Lab, Institute of Minerals and Materials Technology (IMMT), Bhubaneswar, Odisha, India
Dept of ECE, Hi-Tech Institute of Technology, Khurda, Odisha, India
This paper describes the design of an ultrasonic transducer using different lead free piezo-electric materials and evaluates their performance with different glucose levels in the human blood. COMSOL Multiphysics 4.2a was used for the simulation study using 2D axis symmetric model of piezoelectric transducer which was designed with lead free piezoelectric materials such as Barium Sodium Niobate ...
S. Mackintosh, J. Rodgers, S.P. Blythe
Lifescan Scotland, Inverness, Scotland
This paper describes the modeling of a blood glucose sensor using COMSOL Multiphysics. Chemical species interaction and diffusion, coupled with electrochemical oxidation of multiple blood species produced a powerful working model used in developing and refining a range of blood glucose sensors for the commercial market.
A. D. Haydock, J. Melrose, P. Rayment, M. F. Butler, and G. Lian
Unilever R&D Colworth, Colworth House, Sharnbrook Bedford, UK
In this presentation, we describe the use of COMSOL for modeling release of active molecules from hydrogels as a model system of structured foods. We first discuss the structural changes of hydrogel in the gastro-intestinal (GI) tract environment and how this is modelled mathematically. We then discuss how to implement the mathematical equations in COMSOL. Computer simulations have been performed ...
Estimating Cerebral Blood Flow using Electro-mechanical Modeling and Impedance Tomography Measurements
A. Jeremic, and T. Gadkari
McMaster University, Hamilton, ON, Canada
In this paper we propose a coupled electromechanical finite element model which combines the Navier-Stokes Equations of blood flow in an immersed boundary and the resulting deformed geometry with an electromagnetic model, which describes the electric field in the presence of deformation/structure changes caused by the blood flow in arteries.We derive least-squares estimates of the pressure drop ...
3-D Multiphysics FEM Modeling to Optimize Local Drug Delivery in a Biohybrid Device Designed for Cell Transplant
N. Bocca, C. Ricordi, N. S. Kenyon, P. Latta, and P. Buchwald
Diabetes Research Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA
To evaluate the possibility of achieving drug concentration levels required for localized immunosuppression and to optimize sustained, local delivery within small, subcutaneously implanted, prevascularized biohybrid devices designed to achieve long-term survival of transplanted pancreatic islets, finite element method (FEM)-based models have been implemented in COMSOL Multiphysics. To obtain a ...
A. Eed Olamat, U. Hofmann, B. Pohl, and N. Nkemasong
University of Lübeck, Institute for Signal Processing, Lübeck, Germany
In order to investigate the implantation of microprobes into brain tissue, we developed a finite-element and a physical model to replace real biological tissue for mechanical testing. Penetrating forces of a tungsten indenter into a layered structure was investigated with different indentation speeds. Numerical and physical model are in good correspondence to each other and reproduce measured ...
L. Murtomäki, and S. Kotha
University of Helsinki, Centre for Drug Research, Helsinki, Finland
Drug therapy of the posterior part of an eye is very challenging. Yet, in USA alone, there are almost 2 million people affected by age related macular degeneration. When designing a strategy for controlled-release drug delivery, it is important to take into account of physiology, absorption, distribution, metabolism, and excretion properties of a drug. Therefore, the aims of this study are: 1) to ...