Technical Papers and Presentations

Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Numerical Validation of the Efficiency of Dual-Frequency Radiofrequency Ablation

A. Candeo[1] and F. Dughiero[1]
[1]Department Electrical Engineering, University of Padova, Padova, Italy

Radiofrequency Ablation (RFA) represents a valid alternative for treating liver metastases in medically complicated patients. Conventional devices currently operate at 500 kHz, due to good conducting properties of tissues. However, the use of lower frequencies (i.e. 20 kHz) has been recently reported to enhance the treatment effectiveness, due to a more pronounced difference in electrical ...

Simulation of Transport of Lipophilic Compounds in Complex Cell Geometry

Q.A. Chaudhry[1], M. Hanke[1], and R. Morgenstern[2]
[1]School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden
[2]Karolinska Institutet, Stockholm, Sweden

The mathematical modeling of the diffusion and reaction of toxic compounds in mammalian cells is tough task due to their very complex geometry. The heterogeneity of the cell, particularly the cytoplasm, and the variation of the cellular architecture, greatly affects the behavior of these toxic compounds. Homogenization techniques have been implemented for the numerical treatment of the model. ...

Modeling of Nerve Stimulation Thresholds and Their Dependence on Electrical Impedance with COMSOL

P. Krastev[1], and B. Tracey[1]
[1]Neurometrix, Inc., Waltham, Massachusetts, USA

Nerve localization is important for applications in regional anesthesia. Localization is achieved by stimulating the nerve with an electric field produced by a current from a needle inserted into the body of the patient, close to the target nerve.  Modeling of the electric field in close proximity to the nerve may help to explain observed variations in threshold currents and can help to ...

Finite Element Analysis of Microscale Luminescent Glucose Sensors in the Skin Dermis

S. Ali[1], and M. McShane[1]
[1]Department of Biomedical Engineering, Texas A&M University-College Station, Texas, USA

With the rising predominance of diabetes, successful management of blood glucose levels is increasingly important. Key efforts have focused on the development of optical microscale glucose sensing systems based on the encapsulation of glucose oxidase within microspheres coated with polyelectrolyte multilayer nanofilms. A two-substrate mathematical model of microscale optical glucose sensors in ...

Numerical Methods used in Biomedical Technology

Klaus Liefeith
Institut für Bioprozess- und Analysemesstechnik e.V.
Heiligenstadt

Breakthroughs in biomedicine and IT have provided a wealth (mountain) of data where the key post-genomic challenge is to transform this data into information that can be used to determine biomaterial function. Biomaterial functions arise from complex nonlinear interactions between biological processes occurring over multiple spatial and temporal scales Gaining an understanding of these ...

Contact and No-Compression Analysis of a Human Spine Segment: Theory, Method and Parametric Investigation

P. Nédli1, G. E. Stavroulakis2, and M. Kurutz1
1 Department of Structural Mechanics, Budapest University of Technology and Economics, Budapest, Hungary
2 Institute of Computational Mechanics and Optimization, Technical University of Crete, Chania, Greece

Various two-dimensional models of lumbar spine segments, that is, lumbar functional spinal units (FSU) have been developed and studied here. FSU is the smallest part of the spine that has all the important features that the whole spine has. It consists of two adjacent vertebrae with the intervertebral disc between them and the surrounding ligaments.Since the spine segment has a symmetrical ...

Using High-energy Lasers to Heat and Kill the Cells in an Internal Cancerous Body Tumor

O. Skovgaard, M. S. Enevoldsen, L. J. Delay, and L. B. Hansen
Department of Mathematics, Technical University of Denmark, Lyngby, Denmark

High energy lasers are expected to be useful in the future to heat and kill the cells in internal cancerous human body tumors. It is proposed to use several very thin fibers to transfer the energy from the laser sources to the surface of a tumor or to any inner point of a tumor. Each laser source may produce a steady-state signal or a time signal corresponding to a pulsating function. Prior to ...

On the Simulation of the Metabolism in Mammalian Cells using Homogenization Methods

M. Hanke, and M. Cabauatan-Villanueva
School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden

The simulation of the metabolism in mammalian cells becomes a severe problem if spatial distributions must be taken into account. Especially the cytoplasma has a very complex geometric structure which cannot be handled by standard discretization techniques. In the present paper we propose a homogenization technique for computing effective diffusion constants. This is accomplished by using a ...

Modelling the Coupled Heat and Mass Transfer during Fires in Stored Biomass, Coal and Recycling Deposits

F. Ferrero
Federal Institute for Materials Research and Testing Division II.2, Berlin, Germany

It is known that in big storages of bulk materials the danger of the self-ignition is relevant (long time storages). The Consequences of uncontrolled fires include considerable CO2 emission and economical and human losses to mention a few. The understanding of this phenomena is therefore of great importance.A numerical model can be of great help in understanding such complex phenomena. In this ...

Estimating Cerebral Blood Flow using Electro-mechanical Modeling and Impedance Tomography Measurements

A. Jeremic, and T. Gadkari
McMaster University, Hamilton, ON, Canada

In this paper we propose a coupled electromechanical finite element model which combines the Navier-Stokes Equations of blood flow in an immersed boundary and the resulting deformed geometry with an electromagnetic model, which describes the electric field in the presence of deformation/structure changes caused by the blood flow in arteries.We derive least-squares estimates of the pressure drop ...

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