Technical Papers and Presentations

Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Biosimulation of Normal Pressure Hydrocephalus Using COMSOL Multiphysics®

K. Shahim[1], J-M. Drezet[1], J-F. Molinari[2], S. Momjian[3], and R. Sinkus[4]

[1]LSMX, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
[2]LSMS, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
[3]University Hospitals of Geneva and University of Geneva, Switzerland
[4]Waves and Acoustics Laboratory, ESPCI, Paris, France

A numerical finite element model of one human brain is built in COMSOL in order to study a particular form of hydrocephalus, the so called Normal Pressure Hydrocephalus (NPH). The geometry of the ventricles and the skull is obtained by Magnetic Resonance Imaging (MRI) and imported in COMSOL Multiphysics. Form the mechanical point of view, the brain parenchyma is modeled as a porous medium fully ...

Numerical Validation of the Efficiency of Dual-Frequency Radiofrequency Ablation

A. Candeo[1] and F. Dughiero[1]
[1]Department Electrical Engineering, University of Padova, Padova, Italy

Radiofrequency Ablation (RFA) represents a valid alternative for treating liver metastases in medically complicated patients. Conventional devices currently operate at 500 kHz, due to good conducting properties of tissues. However, the use of lower frequencies (i.e. 20 kHz) has been recently reported to enhance the treatment effectiveness, due to a more pronounced difference in electrical ...

Modeling of Nerve Stimulation Thresholds and Their Dependence on Electrical Impedance with COMSOL

P. Krastev[1], and B. Tracey[1]
[1]Neurometrix, Inc., Waltham, Massachusetts, USA

Nerve localization is important for applications in regional anesthesia. Localization is achieved by stimulating the nerve with an electric field produced by a current from a needle inserted into the body of the patient, close to the target nerve.  Modeling of the electric field in close proximity to the nerve may help to explain observed variations in threshold currents and can help to ...

Designing an Array of Nanocalorimeters for Screening Biochemical Interactions

F. Torres
Palo Alto Research Center

In this presentation we present our analysis of the PARC Nanocalorimeter. Calorimetry is basically the measuring of heat of chemical reactions or physical changes. Nanocalorimetry is Calorimetry at the Nanometer scale. The PARC Nanocalorimeter is a special type of Calorimeter, it consists of arrays of Nanocalorimeters. The PARC Nanocalorimeter is intended to be used for screening biochemical ...

Assessment of Hemodynamic Conditions in a-v Fistulas using CFD

A. K. Niemann1,5, S. A. Kock1, J. V. Nygaard2, E-T. Fründ3, S. E. Petersen4, and J. M. Hasenkam5
1 MR-center, Aarhus University Hospital Skejby, Aarhus, Denmark
2Interdisciplinary Nanoscience Center, Faculty of Science, University of Aarhus, Skejby, Denmark
3Dept. of Radiology, Aarhus University Hospital, "Aalborg Sygehus Syd", Aalborg, Denmark
4Dept. of Urology, Aarhus University Hospital Skejby, Aarhus, Denmark
5Dept. of Cardio-Thoracic and Vascular Surgery, and Clinical Institute, Aarhus University Hospital Skejby, Aarhus, Denmark

Using Computational Fluid Dynamics, different geometries of side-to-side a-v fistulas for hemodialysis access are evaluated. We created five CAD-models of fistulas with the length of the anastomosis varying from 5 to 15 mm. The five models were analyzed and evaluated using the k-ε turbulence application mode in COMSOL Multiphysics to determine if an optimal length of anastomosis exists. ...

Comparison of Mathematical Modeling of Laser-induced Thermotherapy (LITT) to Experimental Data: Determination of Optimal Laser Parameters

B. Wassmer1, R. Viard2, J. Zemmouri1, P. Rochon2, J. Rousseau2, and S. R. Mordon2
1Osyris SA, Hellemmes, France
2INSERM U703 - IFR 114, CHU Lille, Lille, France

Liver metastasis is a major problem in public health. Laser-induced interstitial thermotherapy (LITT) is a recently developed, minimally invasive technique for local tumor destruction within solid organs. This technique consists of inserting a laser fiber inside the metastasis. The study aimed to determine laser parameters (power, time, duty cycle) and fiber type (bare, diffusing) in order to ...

Estimating Cerebral Blood Flow using Electro-mechanical Modeling and Impedance Tomography Measurements

A. Jeremic, and T. Gadkari
McMaster University, Hamilton, ON, Canada

In this paper we propose a coupled electromechanical finite element model which combines the Navier-Stokes Equations of blood flow in an immersed boundary and the resulting deformed geometry with an electromagnetic model, which describes the electric field in the presence of deformation/structure changes caused by the blood flow in arteries.We derive least-squares estimates of the pressure drop ...

An Elastic and Hyperelastic Material Model of Joint Cartilage - Calculation of the Pressure Dependent Modulus of Elasticity by Comparison with Experiments and Simulations

T. Reuter, and M. Hoffmann
fzmb GmbH
Research Centre of Medical Technology and Biotechnology
Bad Langensalza, Germany

In this paper we introduce a elastic and hyperelastic model to describe the biomechanics of joint cartilage. As biomechanical property we calculated the pressure dependent E-modulus E = f(s) to describe the dependence of the biomechanical properties on pressure. The calculation based on the comparison and the iterative approach of the force-way-functions between the experiments and ...

Simulation of Transport of Lipophilic Compounds in Complex Cell Geometry

Q.A. Chaudhry[1], M. Hanke[1], and R. Morgenstern[2]
[1]School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden
[2]Karolinska Institutet, Stockholm, Sweden

The mathematical modeling of the diffusion and reaction of toxic compounds in mammalian cells is tough task due to their very complex geometry. The heterogeneity of the cell, particularly the cytoplasm, and the variation of the cellular architecture, greatly affects the behavior of these toxic compounds. Homogenization techniques have been implemented for the numerical treatment of the model. ...

Contact and No-Compression Analysis of a Human Spine Segment: Theory, Method and Parametric Investigation

P. N├ędli1, G. E. Stavroulakis2, and M. Kurutz1
1 Department of Structural Mechanics, Budapest University of Technology and Economics, Budapest, Hungary
2 Institute of Computational Mechanics and Optimization, Technical University of Crete, Chania, Greece

Various two-dimensional models of lumbar spine segments, that is, lumbar functional spinal units (FSU) have been developed and studied here. FSU is the smallest part of the spine that has all the important features that the whole spine has. It consists of two adjacent vertebrae with the intervertebral disc between them and the surrounding ligaments.Since the spine segment has a symmetrical ...

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