Downscale Finite Element Modeling of Aortic Valve Leaflets for In-Situ Estimation of Cell Level Mechanics
R. Buchanan, M. Sacks
Institute for Computational Engineering and Sciences, Department of Biomedical Engineering, University of Texas, Austin, TX, USA
As in all tissues, mechanical forces in the aortic valve (AV) modulate the constituent cell population’s physiology and biosynthetic activity. While advances have been made toward the understanding of this complex multi-scale relationship, the specific role that and extracellular matrix (ECM) coupling plays on the mechanical response of the AV interstitial cell (AVIC) is poorly understood. The ...
N. Mane, A. Gaikwad
Department of Instrumentation, Cummins College of Engineering, Pune, Maharashtra, India
Micro electro-mechanical system (MEMS) is rapidly growing area of interest for a broad spectrum of applications. One particularly fast-growing area is biomedical applications for micromaching technologies. One application of interest to the biomedical industry is the development of microneedles. MEMS technology brings new means for biomedicine field. Patch-based transdermal drug delivery offers ...
K. Shahim, J-M. Drezet, J-F. Molinari, S. Momjian, and R. Sinkus
LSMX, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
LSMS, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
University Hospitals of Geneva and University of Geneva, Switzerland
Waves and Acoustics Laboratory, ESPCI, Paris, France
A numerical finite element model of one human brain is built in COMSOL in order to study a particular form of hydrocephalus, the so called Normal Pressure Hydrocephalus (NPH). The geometry of the ventricles and the skull is obtained by Magnetic Resonance Imaging (MRI) and imported in COMSOL Multiphysics. Form the mechanical point of view, the brain parenchyma is modeled as a porous medium fully ...
Image-Based Simulation of Electrical Impedance Techniques Applied on the Human Thorax for Cardio-Pulmonary Applications
F.K. Hermans, R.M. Heethaar, R.T. Cotton, and A. Harkara
VU University Medical Center, Amsterdam, The Netherlands
Simpleware Ltd., Exeter, United Kingdom
For medical diagnostic purposes there is an increasing need for non- (or minimal) invasive techniques to measure all kinds of parameters that can provide insight in the functioning of cells, organs or organ systems. Currently, Impedance Cardiography (ICG) is used for measurements of the heart and Electric Impedance Tomography (EIT) is used for investigating lung tissue condition. This paper ...
Contact and No-Compression Analysis of a Human Spine Segment: Theory, Method and Parametric Investigation
P. Nédli1, G. E. Stavroulakis2, and M. Kurutz1
1 Department of Structural Mechanics, Budapest University of Technology and Economics, Budapest, Hungary
2 Institute of Computational Mechanics and Optimization, Technical University of Crete, Chania, Greece
Various two-dimensional models of lumbar spine segments, that is, lumbar functional spinal units (FSU) have been developed and studied here. FSU is the smallest part of the spine that has all the important features that the whole spine has. It consists of two adjacent vertebrae with the intervertebral disc between them and the surrounding ligaments.Since the spine segment has a symmetrical ...
N. El Khatib1, S. Genieys1, M. Zine2, and V. Volpert1
1Institut Camille Jordan, Université Claude Bernard, Lyon, France
2Département Maths & Informatique, Ecole Centrale de Lyon, Lyon, France
The development of atherosclerosis leads to the formation of an atheroma plaque which takes place in the artery. This plaque is composed of two parts: a lipid deposit and a fibrous cap. The fibrous cap covers the lipid deposit and isolates it from the blood flow. The blood flow that circulates in the artery modifies the geometry of the atheroma plaque and can cause dangerous effects, such as a ...
Q.A. Chaudhry, M. Hanke, and R. Morgenstern
School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden
Karolinska Institutet, Stockholm, Sweden
The mathematical modeling of the diffusion and reaction of toxic compounds in mammalian cells is tough task due to their very complex geometry. The heterogeneity of the cell, particularly the cytoplasm, and the variation of the cellular architecture, greatly affects the behavior of these toxic compounds. Homogenization techniques have been implemented for the numerical treatment of the model. ...
Palo Alto Research Center
In this presentation we present our analysis of the PARC Nanocalorimeter. Calorimetry is basically the measuring of heat of chemical reactions or physical changes. Nanocalorimetry is Calorimetry at the Nanometer scale. The PARC Nanocalorimeter is a special type of Calorimeter, it consists of arrays of Nanocalorimeters. The PARC Nanocalorimeter is intended to be used for screening biochemical ...
Comparison of Mathematical Modeling of Laser-induced Thermotherapy (LITT) to Experimental Data: Determination of Optimal Laser Parameters
B. Wassmer1, R. Viard2, J. Zemmouri1, P. Rochon2, J. Rousseau2, and S. R. Mordon2
1Osyris SA, Hellemmes, France
2INSERM U703 - IFR 114, CHU Lille, Lille, France
Liver metastasis is a major problem in public health. Laser-induced interstitial thermotherapy (LITT) is a recently developed, minimally invasive technique for local tumor destruction within solid organs. This technique consists of inserting a laser fiber inside the metastasis. The study aimed to determine laser parameters (power, time, duty cycle) and fiber type (bare, diffusing) in order to ...
K. K. Sriperumbudur, P. J. Koester, M. Stubbe, C. Tautorat, J. Held, W. Baumann, and J. Gimsa
 University of Rostock, Chair of Biophysics, Gertrudenstr. 11a, 18057 Rostock, Germany
 Microsystem Material Laboratory, Department of Microsystems Engineering (IMTEK), University of Freiburg, Germany
In spite of its low throughput, Patch-Clamp is the established method for intracellular measurements of the transmembrane potential. To address this problem, we have developed new biosensor-chips with micro-structured needle electrodes (MNEs). MNE-penetration of single cells growing on the MNE-tips leads to a situation comparable to the whole-cell mode in classical Patch Clamp. MNE-penetration ...