Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Computational Design and Optimization of Bone Tissue Engineering Scaffold Topology

N. P. Uth [1], J. Mueller [2], B. Smucker [3], A. Yousefi [1],
[1] Department of Chemical, Paper, and Biomedical Engineering, Miami University, Oxford, OH, USA
[2] Research Computing Support, Miami University, Oxford, OH, USA
[3] Department of Statistics, Miami University, Oxford, OH, USA

Introduction: Bone tissue has a limited ability for regeneration; critically sized defects cannot self-heal and require medical intervention. Bone tissue engineering (TE) circumvents this issue by growing replacement bone tissue from the patient’s own cells inside scaffolds. TE scaffolds are porous constructs that act as a support structure during bone regeneration and helps cells attach and ...

Bending of a Stented Atherosclerotic Artery

H.C. Wong[1], K.N. Cho[1], and W.C. Tang[1]

[1]Department of Biomedical Engineering, University of California, Irvine, California, USA

Atherosclerosis causes the deposition of plaque on the inner walls of arteries, which leads to restricted blood flow. Using the balloon angioplasty procedure, stents can be inserted and expanded in the atherosclerotic artery. We used COMSOL Multiphysics Structural Mechanics, Solid Stress-Strain module to perform static, large deformation analyses. Our results show that lower stent stresses were ...

Simulation and Design of a Microfluidic Respirometer for Semi-Continuous Amperometric Short Time Biochemical Oxygen Demand (BODST) Analysis

F.J. del Campo[1], A. Torrents[1], J. Mas[2], F.X. Muñoz[1]
[1]Instituto de Microelectronica de Barcelona, IMB-CNM (CSIC), Campus Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
[2]Departement de Genètica i Microbiologia, Campus Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain

Introduction: This work presents the design of a novel flow cell based miniaturized electrochemical respirometer to monitor organic content in water samples semi-continuously, in contrast to current Biochemical Oxygen Demand, BOD, methods. Simulation techniques has been used to parameterize and optimize aspects such as height and length of the channels, materials and thickness, flow and oxygen ...

Polymer Compositional Profile Controls By-Product Fate from Erodible Endovascular Scaffolds

T. Shazly, and J. Ferdous
Biomedical Eng., Mechanical Eng. Dept.
University of South Carolina
Columbia, SC

Erodible polymeric scaffolds can mitigate long-term risks associated with permanent implants currently used to treat ischemic artery disease. However, safe deployment of erodible scaffolds is predicated on understanding the interactions between evolved material by-products and local biological tissues. We developed an integrated computational model of polymeric scaffold degradation, by ...

Fluid Dynamics of Blood Flow during Reperfusion and Post-conditioning

T. Merrill[1], A. La Barck[1], and J. Docimo[2]
[1]Rowan University, Glassboro, New Jersey, USA
[2]FocalCool, LLC, Mullica Hill, New Jersey, USA

Reperfusion injury is caused by the rapid restoration of blood flow to oxygen-starved tissue. Animal studies show that intermittent periods of occlusion (also called post-conditioning) during reperfusion can limit tissue damage to vital organs such as the heart and brain. These studies suggest that the protective effects of post-conditioning relate to the dynamics of blood flow. COMSOL is being ...

Simulating Microbubble Flows Using COMSOL Multiphysics

X. Chen[1], and S. Ghadiali[1,2]

[1]Mechanical Engineering and Mechanics, Lehigh University, Bethlehem, PA, USA
[2]Bio Engineering program, Lehigh University, Bethlehem, PA, USA

Acute respiratory distress syndrome (ARDS) is a severe lung disease caused by a variety of direct and indirect insults. The main treatment for ARDS is mechanical ventilation. The ventilation of fluid filled lungs involves the propagation of microbubbles over a layer of epithelial cells. We utilized COMSOL® with MATLAB® to develop a time dependent computational model of semi-infinite air ...

Modeling of Tumor Location Effect in Breast Microwave Imaging using COMSOL

E. Khosrowshahli[1], and A. Jeremic[2]
[1]School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada
[2]McMaster University, Dept. of Electrical and Computer Engineering, McMaster University,
Hamilton, ON, Canada

Microwave imaging has been recently proposed as a potentially useful screening technique for breast cancer. This method detects abnormalities in the tissue based on permittivity difference between breast normal and malignant tissue. In this method breast is illuminated by high frequency electromagnetic wave, and received waves are then analyzed in order to construct a map of breast\'s ...

Analyzing Drug Delivery and Osteoblast Growth on a Porous Scaffold in a Perfusion Bioreactor

A. Sun, and S. Murray
Dept. of Biomedical Engineering
UCLA, Los Angeles, CA

Implantable Collagen sponges are used in Spinal Surgery as Drug Delivery Scaffolds. An optimal concentration of growth factor that strikes a balance between bone growth and adverse diffusion effects is difficult to find. The porous sponge also serves as a scaffold for Osteoblast growth, and fluid shear has been shown to mediate biological effects on that cell type. We use COMSOL Multiphysics ...

Design of Microneedle Array for Biomedicine

N. Mane[1], A. Gaikwad[1]
[1]Department of Instrumentation, Cummins College of Engineering, Pune, Maharashtra, India

Micro electro-mechanical system (MEMS) is rapidly growing area of interest for a broad spectrum of applications. One particularly fast-growing area is biomedical applications for micromaching technologies. One application of interest to the biomedical industry is the development of microneedles. MEMS technology brings new means for biomedicine field. Patch-based transdermal drug delivery offers ...

Feed-forward/Feed-backward Mechanical Amplification in the Mouse Cochlea

J. Soons[1,2], C. Steele[2], S. Puria[2]
[1]Lab of Biomedical physics, University of Antwerp, Antwerp, Belgium
[2]Department of Mechanical Engineering, Stanford University, Stanford, USA

Sound vibrations are collected from the external environment by the eardrum and are guided to the basilar membrane in the cochlea. Pressure differences in the two scalae of the cochlea result in a traveling wave on the basilar membrane. The tiny displacements are detected by the deflection of thousands of hair cells, situated along this membrane. It is hypothesized that some 3/4 of these hair ...