Technical Papers and Presentations

Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Modelling of Thermally Induced Electrical Instabilities in Intestine using COMSOL Multiphysics®

A. Gizzi[1][3], C. Cherubini[1][2], S. Migliori[1][3], and S. Filippi[1][2]
[1]Nonlinear Physics and Mathematical Modeling Lab, Engineering Faculty, University Campus Bio-Medico, Roma, Italy
[2]International Center for Relativistic Astrophysics, University of Rome La Sapienza, Roma, Italy
[3]Alberto Sordi Foundation, Research Institute on Aging, Roma, Italy

Postoperative or paralytic Ileus (PI) is a temporary aftermath of major abdominal surgeries. PI prevents the passage of food throughout the lumen leading to bloating, distension, emesis and pain. A plausible mathematical model for this phenomenology physiologically fine tuned including thermal variations, is presented here. Using COMSOL Multiphysics the existing intestinal ionic model have been ...

Bending of a Stented Atherosclerotic Artery

H.C. Wong[1], K.N. Cho[1], and W.C. Tang[1]

[1]Department of Biomedical Engineering, University of California, Irvine, California, USA

Atherosclerosis causes the deposition of plaque on the inner walls of arteries, which leads to restricted blood flow. Using the balloon angioplasty procedure, stents can be inserted and expanded in the atherosclerotic artery. We used COMSOL Multiphysics Structural Mechanics, Solid Stress-Strain module to perform static, large deformation analyses. Our results show that lower stent stresses were ...

An Efficient Finite Element Analysis on an RF Structure Used to Evaluate the Effect of Microwave Radiation on Uveal Melanoma Cells

A. Dulipovici[1], D. Roman[2], I. Stiharu[2], and V. Nerguizian[1]

[1]École de technologie supérieure, Montreal, Quebec, Canada
[2]Concordia University, Montreal, Quebec, Canada

The use of Microwave/RF energy on cancer cells is explored for tumor ablation using medium power level ranging between a few Watts to about 50 Watts. In this research, low power levels, less than 100 mWatt, are used to evaluate the effect of this energy on Uveal melanoma cells by proliferation tests. The COMSOL simulation of the RF structure used to evaluate the radiation energy on ...

Assessment of Hemodynamic Conditions in a-v Fistulas using CFD

A. K. Niemann1,5, S. A. Kock1, J. V. Nygaard2, E-T. Fründ3, S. E. Petersen4, and J. M. Hasenkam5
1 MR-center, Aarhus University Hospital Skejby, Aarhus, Denmark
2Interdisciplinary Nanoscience Center, Faculty of Science, University of Aarhus, Skejby, Denmark
3Dept. of Radiology, Aarhus University Hospital, "Aalborg Sygehus Syd", Aalborg, Denmark
4Dept. of Urology, Aarhus University Hospital Skejby, Aarhus, Denmark
5Dept. of Cardio-Thoracic and Vascular Surgery, and Clinical Institute, Aarhus University Hospital Skejby, Aarhus, Denmark

Using Computational Fluid Dynamics, different geometries of side-to-side a-v fistulas for hemodialysis access are evaluated. We created five CAD-models of fistulas with the length of the anastomosis varying from 5 to 15 mm. The five models were analyzed and evaluated using the k-ε turbulence application mode in COMSOL Multiphysics to determine if an optimal length of anastomosis exists. ...

A Mean Field Approach to Many-particles Effects in Dielectrophoresis

O. Nicotra, and A. La Magna
CNR-IMM Sezione di Catania, Catania, Italy

One of the major applications for dielectrophoresis is the selective trapping and fractionation in lab-on-a-chip devices. Nevertheless, many-particle effects due to high concentrations of biological material around electrodes can cause a rapid decrease of trapping efficiency in dielectrophoretic devices. In this contribution we present a new approach based on a drift-diffusion dynamics to study ...

Investigations on Natural Frequencies of Individual Spherical and Ellipsoidal Bakery Yeast Cells

M.M Zarandi[1], A. Bonakdar[1], and I. Stiharu[2]
[1]McGill University, Montreal, QC, Canada
[2]Concordia University, Montreal, QC, Canada

In this paper, a Finite Element (FE) and scaled-up experimental modal analysis are employed to estimate the natural frequencies of individual spherical and ellipsoidal cells. It is apparent that the mechanical properties of the living cells and particularly the natural frequencies might be related to the health condition of cells, and therefore a comprehensive analysis is carried out to determine ...

Large Scale Invasion Of New Species And Of Genetic Information

O. Richter, F. Suhling, and S. Moenickes
Technische Universität Braunschweig, Germany

The spatial dynamics of the invasion of new species and genetic dispersal is studied under the presumption of rising temperature by using a coherent approach of coupled partial differential equations of the reaction diffusion type. The nonlinear reaction terms model the population dynamics, genetic exchange and competition. Temperature reaction norms of reproduction rates are conferred by a two ...

Dynamic Simulation Of Particle Self-Assembly Applied To Microarray Technology

V. Di Virgilio, A. Coll, S. Bermejo, and L. Castañer
Universitat Politecnica de Catalunya, Barcelona, Spain

In this work we want to explore some techniques, microfluidic and electrospray-ionization based, suitable for dynamic microarrays\' fabrication. The fabrication techniques are based on manipulation and self-assembly of selective coated micro and nanobeads. The simulation will include electro-osmotic flow, species transport, and electrostatics.

Downscale Finite Element Modeling of Aortic Valve Leaflets for In-Situ Estimation of Cell Level Mechanics

R. Buchanan[1], M. Sacks[1]
[1]Institute for Computational Engineering and Sciences, Department of Biomedical Engineering, University of Texas, Austin, TX, USA

As in all tissues, mechanical forces in the aortic valve (AV) modulate the constituent cell population’s physiology and biosynthetic activity. While advances have been made toward the understanding of this complex multi-scale relationship, the specific role that and extracellular matrix (ECM) coupling plays on the mechanical response of the AV interstitial cell (AVIC) is poorly understood. The ...

Local Electroporation of Single Adherent Cells by Micro-Structured Needle Electrodes

K. K. Sriperumbudur[1], P. J. Koester[1], M. Stubbe[1], C. Tautorat[1], J. Held[2], W. Baumann[1], and J. Gimsa[1]
[1] University of Rostock, Chair of Biophysics, Gertrudenstr. 11a, 18057 Rostock, Germany
[2] Microsystem Material Laboratory, Department of Microsystems Engineering (IMTEK), University of Freiburg, Germany

In spite of its low throughput, Patch-Clamp is the established method for intracellular measurements of the transmembrane potential. To address this problem, we have developed new biosensor-chips with micro-structured needle electrodes (MNEs). MNE-penetration of single cells growing on the MNE-tips leads to a situation comparable to the whole-cell mode in classical Patch Clamp. MNE-penetration ...

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