Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Numerical Homogenization in Multi-scale Models of Musculoskeletal Mineralized Tissues

A. Gerisch[1], S. Tiburtius[1], Q. Grimal[2], and K. Raum[3]
[1]Technische Universität Darmstadt, Darmstadt, Germany
[2]Laboratoire d’Imagerie Paramétrique, UPMC, Paris, France
[3]Julius Wolff Institut & Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany

Musculoskeletal mineralized tissues (MMTs), e.g. bone, are hierarchical composite materials. Their effective elastic properties at different scales are of interest for computational studies of the MMT’s response to mechanical loading but also to realistically simulate implant osseointegration. We combine multi-scale and multi-modal experimental techniques with mathematical modelling of MMTs ...

Optimizing Performance of Equipment for Thermostimulation of Muscle Tissue using COMSOL Multiphysics

J. Kocbach[1], K. Folgerø[1], L. Mohn[2], O. Brix[3]
[1]Christian Michelsen Research, Bergen, Norway
[2]Luzmon Norway, Bergen, Norway
[3]Michelsen Medical, Bergen, Norway

The design challenge for thermostimulation equipment is to get a combination of high electric field strength and high temperature within the muscle tissue without causing pain or skin burns. In the present work, COMSOL Multiphysics is used to simulate the temperature distribution and electric field distribution within body tissue for varying body composition and varying design parameters of the ...

Finite Element Analysis of Defibrillation Current Density in Pregnant Women

A. Jeremic[1], E. Khosrowshahli[1]
[1]McMaster University, Hamilton, ON, Canada

Although resuscitation during pregnancy is relatively uncommon and rarely causes death, they have a particularly large impact in terms of the mortality of the unborn child and long-term effects on families and society as whole. In this paper, we present a new 3D finite element model of a pregnant female torso which accounts for presence of amniotic liquid and calculate current density ...

Design and Optimization of Cholesterol Biosensor

N. M. Sundaram[1], M. Alagappan[1]
[1]PSG College of Technology Coimbatore, Tamil Nadu, India

Cholesterol is an essential lipid for human body. The desired total plasma cholesterol for an individual is less than 5.2 mM (200 mg/dL) and it poses a potential health threat when the level is greater than 6.2 mM (240 mg/dL) [1]. Excessive plasma cholesterol causes poor cardiovascular conditions. The experimental fabrication of nano structured biosensor with advanced materials is more expensive ...

Influence of pH and Carbonate Buffering on the Performance of a Lactate Microbial Fuel Cell

A.Torrents, N. Godino, F.J. del Campo, F.X. Muñoz, and J. Mas
Universitat Autònoma de Barcelona, Spain

Microbia Fuel Cells (MFC’s) are complex environments where electrochemical, physical and biological aspects must be considered together. In this work we present a 1D model partially describing a Shewanella oneidensis MFC that degrade sodium lactate [lactate -> Acetate + CO2 + 2H+ + 2e-]. The model, simulated using COMSOL, focuses on pH implications of the MFC operation. Release of protons during ...

Computationally Assisted Design and Experimental Validation of a Novel ‘Flow-Focussed’ Microfluidics Chip for Generating Monodisperse Microbubbles

M. Conneely[1], V. Hegde[2], H. Rolfsnes[1], A. Mason[2], D. McLean[1], C. Main[1], F.J.D. Smith[2], W.H.I. McLean[2], P.A. Campbell[1]
[1]Carnegie Physics Laboratory, University of Dundee, Dundee, Scotland, United Kingdom
[2]Division of Molecular Medicine, University of Dundee, Dundee, Scotland, United Kingdom

Whilst initially developed as a diagnostic aid to improve echogenicity in ultrasound imaging, gas-filled lipid microbubbles are now emerging as a next generation \'theranostic\' tool in the medical arena. Here, their therapeutic potential has now been realized through their unique capability to deliver molecular species such as drugs and genes by means of disrupting the cell membrane in response ...

Electrical Response and Thermal Damage Assessment of Cutaneous and Subcutaneous Tissues to Noninvasive Radiofrequency Heating: A Computational Modeling Study

A. González-Suárez[1,2], J. N. Jimenez-Lozano[3], W. Franco[1]
[1]Wellman Center for Photomedicine, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA
[2]Biomedical Synergy, Electronic Engineering Department, Universitat Politècnica de València, Valencia, Spain
[3]ZELTIQ Aesthetics, Inc., Pleasanton, CA, USA

Electromagnetic radiofrequency (RF) sources are widely used to heat up cutaneous and subcutaneous tissues. The subcutaneous morphology of tissue consists of a fine, collagenous and fibrous septa network enveloping clusters of adipocyte cells; however, it is commonly regarded as a homogeneous fat layer in computational models. In the present study the objective is to assess the effect of the ...

Performance of a Miniaturized Hydrocyclone for the Isolation of Schistosoma Mansoni Eggs - new

C. Soares[1], N. Padoin[1], F. Montalvo[2], D. Cobra[2]
[1]Federal University of Santa Catarina, Florianópolis, SC, Brazil
[2]CERTI Foundation, Florianópolis, SC, Brazil

Schistosoma mansoni parasites affect million people worldwide. The intensity of the infection can be evaluated by the number of eggs present in the stool of an infected individual. The application of the traditional methods has been regarded as impractical in developing areas and there is a continuous search for new techniques. In face of this scenario, a new method of diagnosis was explored in ...

Simulation of Transport of Lipophilic Compounds in Complex Cell Geometry

Q.A. Chaudhry[1], M. Hanke[1], and R. Morgenstern[2]
[1]School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden
[2]Karolinska Institutet, Stockholm, Sweden

The mathematical modeling of the diffusion and reaction of toxic compounds in mammalian cells is tough task due to their very complex geometry. The heterogeneity of the cell, particularly the cytoplasm, and the variation of the cellular architecture, greatly affects the behavior of these toxic compounds. Homogenization techniques have been implemented for the numerical treatment of the model. ...

A Mean Field Approach to Many-particles Effects in Dielectrophoresis

O. Nicotra, and A. La Magna
CNR-IMM Sezione di Catania, Catania, Italy

One of the major applications for dielectrophoresis is the selective trapping and fractionation in lab-on-a-chip devices. Nevertheless, many-particle effects due to high concentrations of biological material around electrodes can cause a rapid decrease of trapping efficiency in dielectrophoretic devices. In this contribution we present a new approach based on a drift-diffusion dynamics to study ...