Technical Papers and Presentations

Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Passive and Active Deformation Processes of 3D Fibre-Reinforced Caricatures of Cardiovascular Tissues

A. Di Carlo[1], P. Nardinocchi[2], T. Svaton[3], and L. Teresi[1]

[1]Modelling and Simulation Lab, Università Roma Tre, Roma, Italy
[2]Dept. of Structural & Geotechnical Engineering, Università di Roma La Sapienza, Roma, Italy
[3]Dept. of Mathematics, University of West Bohemia, Pilsen, Czech Republic

In this paper, we present a mathematical model of contractile elastic solids meant to simulate various districts of the cardiovascular system, and based on the concepts of active deformation and embedded muscle fibres. Specifically, here we deal with the modeling of the gross mechanics of the Left Ventricle (LV) which is strictly related to its pump function. As is well known, the effectiveness ...

Modeling of Nerve Stimulation Thresholds and Their Dependence on Electrical Impedance with COMSOL

P. Krastev[1], and B. Tracey[1]
[1]Neurometrix, Inc., Waltham, Massachusetts, USA

Nerve localization is important for applications in regional anesthesia. Localization is achieved by stimulating the nerve with an electric field produced by a current from a needle inserted into the body of the patient, close to the target nerve.  Modeling of the electric field in close proximity to the nerve may help to explain observed variations in threshold currents and can help to ...

Numerical Methods used in Biomedical Technology

Klaus Liefeith
Institut für Bioprozess- und Analysemesstechnik e.V.
Heiligenstadt

Breakthroughs in biomedicine and IT have provided a wealth (mountain) of data where the key post-genomic challenge is to transform this data into information that can be used to determine biomaterial function. Biomaterial functions arise from complex nonlinear interactions between biological processes occurring over multiple spatial and temporal scales Gaining an understanding of these ...

An Inverse Model for Estimating Arterial Wall Elasticity using the Immersed Boundary Method

A. Jeremic, and T. Gadkari
McMaster Univerisity, Hamilton, ON, Canada

In this paper, we develop an inverse finite-element model for estimating elasticity of the arterial wall. We model the blood flow using COMSOL’s Structural Mechanics module, and use the resulting nonlinear functions corresponding to the Navier-Stokes equations in the presence of elastic (immersed) boundary in formulating the cost function.We derive the corresponding least-squares and maximum ...

Temperature Excursions at the Pulp-Dentin Junction during the Curing of Light-Activated Dental Restorations

M. Jakubinek[1,2], C. Neill[1], C. Felix[3], R. Price[2,3], M. White[1,2]

[1]Departments of Chemistry and Physics, Dalhousie University, Halifax, NS, Canada
[2]Institute for Research in Materials, Dalhousie University, Halifax, NS, Canada
[3]Department of Dental Clinical Sciences, Dalhousie University, Halifax, NS, Canada

Heat produced during the curing of light-activated dental restorations could damage the dental pulp. Given the prevalence of composite restorations and the importance of avoiding injury to the pulp, efforts should be made to minimize the temperature increase that occurs at the pulp-dentin junction during light-curing. In this investigation we develop and evaluate a COMSOL Multiphysics FEM tooth ...

Physical and FEM Simulation of Microprobe Insertion into Brain Tissue

A. Eed Olamat, U. Hofmann, B. Pohl, and N. Nkemasong
University of Lübeck, Institute for Signal Processing, Lübeck, Germany

In order to investigate the implantation of microprobes into brain tissue, we developed a finite-element and a physical model to replace real biological tissue for mechanical testing. Penetrating forces of a tungsten indenter into a layered structure was investigated with different indentation speeds. Numerical and physical model are in good correspondence to each other and reproduce measured ...

Shear Induced Detachment Of Microorganisms Attached To A Plane Wall

B. Boulbène, J. Morchain, and P. Schmitz
Université de Toulouse, NSA, UPS, INP, LISBP, Toulouse, France

We present numerical results involving microorganisms adhering to a plane surface submitted to a shear flow. The purpose is to have a better understanding of the removal mechanisms occurring during the cleaning in place of food processing equipments. The biological cell, i.e. the microorganism, is modelled as a rigid obstacle embedded in the bottom wall of the fluid domain. Shear induced ...

Investigation Of Bone Marrow Stem Cells In The Bone Marrow Niche In An In Vitro System

P. Lezuo, M. Stoddart, and M. Alini
AO Research Institute, Davos, Grison, Switzerland

We aim to develop an in vitro culture system to mimic the human bone marrow stem cell niche in an artificial perfusion bioreactor environment to culture human adult stem cells. State of the art human bone marrow stem cell research shows that even smallest changes in the physical, thermo dynamical or biochemical environment induce a differentiation of human bone marrow stem cells into other cell ...

Modeling Arterial Drug Transport From Drug-eluting Stents: Effect of Blood Flow on the Concentration Distribution Close to the Endothelial Surface

F. Bozsak, J.-M. Chomaz, and A. I. Barakat
LadHyX, Ecole Polytechnique
Palaiseau, France

Drug-eluting stents (DES) are commonly used for treating coronary atherosclerosis. Despite the broad effectiveness of DES, ~5% of treated patients experience complications including in-stent restenosis and late-stent thrombosis. Furthermore, drugs used in DES not only inhibit proliferation of smooth muscle cells but also affect re-endothelialization. We have developed a computational model of ...

3-Dimensional Blood Cooling Model inside a Carotid Bifurcation

R. Sikorski[1], T. Merrill[1]
[1]Rowan University, Glassboro, NJ, USA

Stroke is caused by an interruption of brain blood supply and is one of the leading causes of death and disability. A mild reduction of 2-5°C in tissue temperature through hypothermia has shown reduced tissue infarct size, increased tissue recovery, and positive neurological effects. This paper seeks to predict the outlet blood temperature in the common carotid bifurcation branches. In our ...

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