V. Di Virgilio, A. Coll, S. Bermejo, and L. Castañer
Universitat Politecnica de Catalunya, Barcelona, Spain
In this work we want to explore some techniques, microfluidic and electrospray-ionization based, suitable for dynamic microarrays\' fabrication. The fabrication techniques are based on manipulation and self-assembly of selective coated micro and nanobeads. The simulation will include electro-osmotic flow, species transport, and electrostatics.
Q.A. Chaudhry, M. Hanke, and R. Morgenstern
School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden
Karolinska Institutet, Stockholm, Sweden
The mathematical modeling of the diffusion and reaction of toxic compounds in mammalian cells is tough task due to their very complex geometry. The heterogeneity of the cell, particularly the cytoplasm, and the variation of the cellular architecture, greatly affects the behavior of these toxic compounds. Homogenization techniques have been implemented for the numerical treatment of the model. ...
Modelling Nutrient Transport in a Hollow-Fiber Membrane Bioreactor with Considerating the sub-Cellular Scale Mass Transfer
N. S. Abdullah1, D. B. Das2, and D. R. Jones1
1Department of Engineering Science, University of Oxford, Oxford, UK
2Department of Chemical Engineering, Loughborough University, Leicestershire, UK
Current bone tissue engineering protocols allow ex vivo growth of soft bone tissues in bioreactors. Recent experimental studies suggest that hollow fiber membrane bioreactors (HFMBs) may be used for growing 3-dimensional, clinically viable bone tissues. In order to facilitate the design of the HFMB for growing bone tissues, it is necessary to elucidate the quantitative relationships between cell ...
K. K. Sriperumbudur, P. J. Koester, M. Stubbe, C. Tautorat, J. Held, W. Baumann, and J. Gimsa
 University of Rostock, Chair of Biophysics, Gertrudenstr. 11a, 18057 Rostock, Germany
 Microsystem Material Laboratory, Department of Microsystems Engineering (IMTEK), University of Freiburg, Germany
In spite of its low throughput, Patch-Clamp is the established method for intracellular measurements of the transmembrane potential. To address this problem, we have developed new biosensor-chips with micro-structured needle electrodes (MNEs). MNE-penetration of single cells growing on the MNE-tips leads to a situation comparable to the whole-cell mode in classical Patch Clamp. MNE-penetration ...
Palo Alto Research Center
In this presentation we present our analysis of the PARC Nanocalorimeter. Calorimetry is basically the measuring of heat of chemical reactions or physical changes. Nanocalorimetry is Calorimetry at the Nanometer scale. The PARC Nanocalorimeter is a special type of Calorimeter, it consists of arrays of Nanocalorimeters. The PARC Nanocalorimeter is intended to be used for screening biochemical ...
C. Morgan, N. Kenkare, M. Williams, A. Peterson, and D. Williams
Alcon Eye Care Division of Novartis R&D, Duluth, GA
Alcon Eye Care Division of Novartis R&D and Georgia Institute of Technology Co-op Program, GA
Introduction of silicone hydrogel contact lens materials provided products of unprecedented capability to deliver oxygen to the eye during wear. One additional material characteristic of interest is the material’s permeability to ions. This paper discusses descriptive tools and optimization of an impedance method of characterizing ion permeability. A physical model of conductive paper with ...
T. Shazly, and J. Ferdous
Biomedical Eng., Mechanical Eng. Dept.
University of South Carolina
Erodible polymeric scaffolds can mitigate long-term risks associated with permanent implants currently used to treat ischemic artery disease. However, safe deployment of erodible scaffolds is predicated on understanding the interactions between evolved material by-products and local biological tissues. We developed an integrated computational model of polymeric scaffold degradation, by-product ...
H.H. Chen-Mayer, and R. Tosh
Ionizing Radiation Division, National Institute of Standards and Technology, Gaithersburg, Maryland, USA
Water calorimetry is employed to establish a primary reference standard for radiation dosimetry by measuring the temperature rises in a water phantom (a cube of about 30 cm x 30 cm x 30 cm) subjected to a beam of ionizing radiation. We use COMSOL Multiphysics to model the system using the Heat Transfer module and the Incompressible Navier-Stokes module with a geometry of 2D-axial ...
An Efficient Finite Element Analysis on an RF Structure Used to Evaluate the Effect of Microwave Radiation on Uveal Melanoma Cells
A. Dulipovici, D. Roman, I. Stiharu, and V. Nerguizian
École de technologie supérieure, Montreal, Quebec, Canada
Concordia University, Montreal, Quebec, Canada
The use of Microwave/RF energy on cancer cells is explored for tumor ablation using medium power level ranging between a few Watts to about 50 Watts. In this research, low power levels, less than 100 mWatt, are used to evaluate the effect of this energy on Uveal melanoma cells by proliferation tests. The COMSOL simulation of the RF structure used to evaluate the radiation energy on ...
A. Eed Olamat, U. Hofmann, B. Pohl, and N. Nkemasong
University of Lübeck, Institute for Signal Processing, Lübeck, Germany
In order to investigate the implantation of microprobes into brain tissue, we developed a finite-element and a physical model to replace real biological tissue for mechanical testing. Penetrating forces of a tungsten indenter into a layered structure was investigated with different indentation speeds. Numerical and physical model are in good correspondence to each other and reproduce measured ...