COMSOL Multiphysics® as a Tool for Reducing Animals in Biomedical Research: An Application in Dermatology
F. Rossi and R. Pini
Istituto di Fisica Applicata “Nello Carrara”, Consiglio Nazionale delle Ricerche, Firenze, Italy
In biomedical research the use of animal models gives rise to several ethical problems. COMSOL Multiphysics® may be used as a non-animal technique, very useful in overcoming all these concerns. In this presentation a particular application in dermatology is shown. Bioheat equation mode and diffusion approximation were used to design a theoretical model of blue LED light interaction with an ...
Y. Song, and C. Wang
Florida International University, Miami, FL, USA
Enzymatic biofuel cells (EBFCs) are miniature, implantable power sources, which use enzymes as catalysts to perform redox reaction with biological fuels such as glucose. In this study using COMSOL Multiphysics, we use an EBFC chip, having three dimensional, highly dense micro-electrode arrays, fabricated by C-MEMS micro-fabrication techniques. Glucose oxidase (GOx) is immobilized on anodes for ...
A. Eed Olamat, U. Hofmann, B. Pohl, and N. Nkemasong
University of Lübeck, Institute for Signal Processing, Lübeck, Germany
In order to investigate the implantation of microprobes into brain tissue, we developed a finite-element and a physical model to replace real biological tissue for mechanical testing. Penetrating forces of a tungsten indenter into a layered structure was investigated with different indentation speeds. Numerical and physical model are in good correspondence to each other and reproduce measured ...
L. Murtomäki, and S. Kotha
University of Helsinki, Centre for Drug Research, Helsinki, Finland
Drug therapy of the posterior part of an eye is very challenging. Yet, in USA alone, there are almost 2 million people affected by age related macular degeneration. When designing a strategy for controlled-release drug delivery, it is important to take into account of physiology, absorption, distribution, metabolism, and excretion properties of a drug. Therefore, the aims of this study are: 1) to ...
V. Di Virgilio, A. Coll, S. Bermejo, and L. Castañer
Universitat Politecnica de Catalunya, Barcelona, Spain
In this work we want to explore some techniques, microfluidic and electrospray-ionization based, suitable for dynamic microarrays\' fabrication. The fabrication techniques are based on manipulation and self-assembly of selective coated micro and nanobeads. The simulation will include electro-osmotic flow, species transport, and electrostatics.
B. Boulbène, J. Morchain, and P. Schmitz
Université de Toulouse, NSA, UPS, INP, LISBP, Toulouse, France
We present numerical results involving microorganisms adhering to a plane surface submitted to a shear flow. The purpose is to have a better understanding of the removal mechanisms occurring during the cleaning in place of food processing equipments. The biological cell, i.e. the microorganism, is modelled as a rigid obstacle embedded in the bottom wall of the fluid domain. Shear induced ...
V. Nicolas[1,2], J.P. Ploteau, P. Salagnac, P. Glouannec, V. Jury, and L. Boillereaux
Laboratoire d’Ingénierie des MATériaux de Bretagne – Equipe Thermique et Energétique, Université Européenne de Bretagne, Lorient Cedex, France
Laboratoire d’Etudes des Phénomènes de Transfert et de l’Instantanéité : Agro-industrie et Bâtiment, Université de La Rochelle, La Rochelle Cedex, France
Laboratoire de Génie des Procédés, Environnement, Agroalimentaire, ENITIAA, France
In this paper, we present a first model carried out with COMSOL Multiphysics to model bread baking, considering heat and mass transfer coupled with the phenomenon of swelling. This model predicts the pressures, temperatures and water contents evolutions in the dough for different energy requests. First results obtained are analyzed according to various physical parameters in order to better ...
L. Murtomäki, T. Kainuvaara
University of Helsinki, Helsinki, Finland
Drug therapy of the posterior segment of an eye is very challenging due to the difficult accessibility. Modern drugs often are large molecules, such as peptides, antibodies or oligonucleotides which are administrated, e.g. by intravitreous injections which requires clinical conditions. Computer modeling can be helpful in designing new and less invasive routes of drug administration. COMSOL is ...
H. Cai, R.P. Jackson, C. Steele, and S. Puria
Stanford University, Stanford, CA, USA
To support high frequency transmission, the mammalian middle ear construction is unique. The middle ear bones are connected through two mobile joints, the malleus-incus joint (MIJ) and the incudostapedial joint (ISJ). These synovial joints, consisting of joint capsule and synovial fluid inside, play an important role in sound transmission. We developed our current FE model using COMSOL that ...
Pranay Goel received his B. Tech. in Engineering Physics from IIT Bombay, and MS and PhD in Physics from the University of Pittsburgh in 2003. He went on to two postodoctoral positions, the first at the Mathematical Biosciences Institute, The Ohio State University, and another at the Laboratory of Biological Modeling, The U.S. National Institutes of Health. He has been with IISER Pune since 2009, ...