Technical Papers and Presentations

Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Bending of a Stented Atherosclerotic Artery

H.C. Wong[1], K.N. Cho[1], and W.C. Tang[1]

[1]Department of Biomedical Engineering, University of California, Irvine, California, USA

Atherosclerosis causes the deposition of plaque on the inner walls of arteries, which leads to restricted blood flow. Using the balloon angioplasty procedure, stents can be inserted and expanded in the atherosclerotic artery. We used COMSOL Multiphysics Structural Mechanics, Solid Stress-Strain module to perform static, large deformation analyses. Our results show that lower stent stresses were ...

An Efficient Finite Element Analysis on an RF Structure Used to Evaluate the Effect of Microwave Radiation on Uveal Melanoma Cells

A. Dulipovici[1], D. Roman[2], I. Stiharu[2], and V. Nerguizian[1]

[1]École de technologie supérieure, Montreal, Quebec, Canada
[2]Concordia University, Montreal, Quebec, Canada

The use of Microwave/RF energy on cancer cells is explored for tumor ablation using medium power level ranging between a few Watts to about 50 Watts. In this research, low power levels, less than 100 mWatt, are used to evaluate the effect of this energy on Uveal melanoma cells by proliferation tests. The COMSOL simulation of the RF structure used to evaluate the radiation energy on ...

Finite Element Analysis Approach for Optimization of Enzyme Activity for Enzymatic Bio-fuel Cell

Y. Song, and C. Wang
Florida International University, Miami, FL, USA

Enzymatic biofuel cells (EBFCs) are miniature, implantable power sources, which use enzymes as catalysts to perform redox reaction with biological fuels such as glucose. In this study using COMSOL Multiphysics, we use an EBFC chip, having three dimensional, highly dense micro-electrode arrays, fabricated by C-MEMS micro-fabrication techniques. Glucose oxidase (GOx) is immobilized on anodes for ...

Investigations on Natural Frequencies of Individual Spherical and Ellipsoidal Bakery Yeast Cells

M.M Zarandi[1], A. Bonakdar[1], and I. Stiharu[2]
[1]McGill University, Montreal, QC, Canada
[2]Concordia University, Montreal, QC, Canada

In this paper, a Finite Element (FE) and scaled-up experimental modal analysis are employed to estimate the natural frequencies of individual spherical and ellipsoidal cells. It is apparent that the mechanical properties of the living cells and particularly the natural frequencies might be related to the health condition of cells, and therefore a comprehensive analysis is carried out to determine ...

Dynamic Simulation Of Particle Self-Assembly Applied To Microarray Technology

V. Di Virgilio, A. Coll, S. Bermejo, and L. Castañer
Universitat Politecnica de Catalunya, Barcelona, Spain

In this work we want to explore some techniques, microfluidic and electrospray-ionization based, suitable for dynamic microarrays\' fabrication. The fabrication techniques are based on manipulation and self-assembly of selective coated micro and nanobeads. The simulation will include electro-osmotic flow, species transport, and electrostatics.

Muscle-Electrode Interface Simulation

A. Altamirano, C. Toledo, A. Vera, R. Muñoz, and L. Leija
Centro de Investigacion y Estudios Avanzados
Instituto Politecnico Nacional
Mexico

In this article, the aim is to study different types and forms of electromyography (EMG) electrodes, for bipolar configuration, and the electric interface with muscle phantom. COMSOL Multiphysics allows modeling shapes and contact surfaces. Surface and needle electrodes will be modeled. A number of different trials and combinations will be presented; exploring different geometric shapes and ...

Local Electroporation of Single Adherent Cells by Micro-Structured Needle Electrodes

K. K. Sriperumbudur[1], P. J. Koester[1], M. Stubbe[1], C. Tautorat[1], J. Held[2], W. Baumann[1], and J. Gimsa[1]
[1] University of Rostock, Chair of Biophysics, Gertrudenstr. 11a, 18057 Rostock, Germany
[2] Microsystem Material Laboratory, Department of Microsystems Engineering (IMTEK), University of Freiburg, Germany

In spite of its low throughput, Patch-Clamp is the established method for intracellular measurements of the transmembrane potential. To address this problem, we have developed new biosensor-chips with micro-structured needle electrodes (MNEs). MNE-penetration of single cells growing on the MNE-tips leads to a situation comparable to the whole-cell mode in classical Patch Clamp. MNE-penetration ...

Simulation of Convection in Water Phantom Induced by Periodic Radiation Heating

H.H. Chen-Mayer[1], and R. Tosh[1]
[1]Ionizing Radiation Division, National Institute of Standards and Technology, Gaithersburg, Maryland, USA

Water calorimetry is employed to establish a primary reference standard for radiation dosimetry by measuring the temperature rises in a water phantom (a cube of about 30 cm x 30 cm x 30 cm) subjected to a beam of ionizing radiation.  We use COMSOL Multiphysics to model the system using the Heat Transfer module and the Incompressible Navier-Stokes module with a geometry of 2D-axial ...

Modeling of Tumor Location Effect in Breast Microwave Imaging using COMSOL

E. Khosrowshahli[1], and A. Jeremic[2]
[1]School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada
[2]McMaster University, Dept. of Electrical and Computer Engineering, McMaster University,
Hamilton, ON, Canada

Microwave imaging has been recently proposed as a potentially useful screening technique for breast cancer. This method detects abnormalities in the tissue based on permittivity difference between breast normal and malignant tissue. In this method breast is illuminated by high frequency electromagnetic wave, and received waves are then analyzed in order to construct a map of breast\'s ...

Material Characterization Method Development: From Education to Design Optimization

C. Morgan[1], N. Kenkare[1], M. Williams[2], A. Peterson[2], and D. Williams[2]
[1]Alcon Eye Care Division of Novartis R&D, Duluth, GA
[2]Alcon Eye Care Division of Novartis R&D and Georgia Institute of Technology Co-op Program, GA

Introduction of silicone hydrogel contact lens materials provided products of unprecedented capability to deliver oxygen to the eye during wear. One additional material characteristic of interest is the material’s permeability to ions. This paper discusses descriptive tools and optimization of an impedance method of characterizing ion permeability. A physical model of conductive paper with ...

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