N.S. Lawand, J. van Driel, P.J. French
Electronic Instrumentation Laboratory (EILab), Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS), Delft University of Technology, Delft, The Netherlands
Delft University of Technology, Delft, The Netherlands
Cochlear Implants are implantable devices which bypasses the non-functional inner ear and directly stimulates the hearing nerve with electric currents thus enabling deaf people to experience sound again. Implant electrode array design is limited in electrode count, due to their large size in accordance to scala tympani (ST) with restrictions for deeper insertion in ST thus depriving access to low ...
I.M. Abdel-Motaleb, K. Ravanasa, K.J. Soderholm
Department of Electrical Engineering, Northern Illinois University, DeKalb, IL, USA
Department of Restorative Dental Sciences, College of Dentistry, University of Florida, Gainesville, FL USA
Studying teeth grinding behavior and other oral conditions requires the ability to accurately measure the pressure on the teeth. Placing a sensor in the mouth requires small size devices with powering and measurement techniques that do not hinder the normal life of the patient. To meet these requirements, we designed, using COMSOL, a small, easy to read MEMS capacitive force sensor, with ...
J. Jimenez-Lozano, P. Vacas-Jacques, W. Franco
Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Radiofrequency (RF) technology offers unique advantages for noninvasive selective heating of relatively large volumes of tissue. In this work, we present a mathematical model for selective non-invasive, non-ablative RF heating of cutaneous and subcutaneous tissue (with detailed fiber septa structures) including their thermo-elastic response. Our analysis shows that the fiber septa architecture ...
Three-Dimensional Finite Element Modeling of Current Density in Maternal Transthoracic Defibrillation
A. Jeremic, J. Potts, E. Khosrowshahli
McMaster University, Hamilton, ON, Canada
McMaster University Hospital, Hamilton, ON, Canada
Although the cardiac arrest in pregnancy is a rare event it can have significant impact in terms of age of mother, mortality of unborn children and consequently long-term effect. One of the commonly used procedures in resuscitation is defibrillation. With recent advances in understanding pathophysiologies in pregnant women it became more obvious that previous studies should be extended to ...
R. Sikorski, B. Chapman, T. Merrill
Rowan University, Glassboro, NJ, USA
A CFD cardiac catheter model was developed to determine the potential for blood hemolysis during administration of local therapeutic hypothermia using a CoolGuide catheter. In vivo animal studies have shown that mild hypothermia may reduce reperfusion injury often associated with heart attack. The CoolGuide Catheter System (CCS) delivers rapid local cooling through a cardiac catheter, reducing ...
Lowering of the Interstitial Fluid Pressure as a Result of Tissue Compliance Changes during High Intensity Focused Ultrasound Exposure: Insights from a Numerical Model
E. Sassaroli, B. O'Neill 
The Methodist Hospital Research Institute, Houston, TX, USA
Interstitial fluid pressure (IFP) is elevated in tumors. Owing to this elevated IFP, the interstitial fluid velocity (IFV) is negligible throughout the tumor but significant near the tumor margin. Any therapeutic strategy that can lower IFP will improve drug convection within the tumor and decrease convection of drugs from the tumor margin. High intensity focused ultrasound (HIFU) has been shown ...
M. Christian, S. Firebaugh, A. Smith
United States Naval Academy, Annapolis, MD, USA
This project utilizes the heat transfer module of the COMSOL Multiphysics environment to model the effects that an ohmic heating probe will have on neural tissue. The model quantifies the thermal impact of active components embedded on a neural micro probe by solving the Penne’s bioheat equation with an external MATLAB function to determine the heat generation along the length of the probe. ...
M. Cartas-Ayala, R. Karnik
Massachusetts Institute of Technology, Cambridge, MA, USA
Characterization of particles has numerous applications in science and diagnostics. Recently, particle passage through constrained microchannels has been proposed to characterize particles based on their passage velocity. Nevertheless, there is no clear understanding of how the physics in this system interact. Here we quantify the effects of the flow around the particle by simulating the passage ...
Finite Element Analysis of Induced Electroosmotic Flow in Brain Tissue and Application to ex vivo Determination of Enzyme Activity
Y. Ou, A. Rupert, M. Sandberg, S. Weber
University of Pittsburgh, Pittsburgh, PA, USA
University of Gothenburg, Gothenburg, Sweden
Ectopeptidases are commonly accepted to be a means of clearing active peptides. However, studies have shown that they can also regulate peptide activity. We have developed a technique of electrokinetic push-pull perfusion (Ek-PPP, Figure 1) to examine this largely unexplored mechanism of modulation of peptide function. We push the neuropeptide galanin through organotypic hippocampal slice ...
T.C. Zhu, B. Liu, X. Liang
University of Pennsylvania, Philadelphia, PA, USA
Singlet oxygen (1O2) is the major cytotoxic agent during photodynamic therapy (PDT). A previously developed model that incorporates the diffusion equation for the light transport in tissue and the macroscopic kinetic equations for the generation of the singlet oxygen, can be used to numerically calculate the distance-dependent reacted 1O2 using finite-element method (FEM). The formula of reacted ...