Technical Papers and Presentations

Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Simulation of Transport of Lipophilic Compounds in Complex Cell Geometry

Q.A. Chaudhry[1], M. Hanke[1], and R. Morgenstern[2]
[1]School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden
[2]Karolinska Institutet, Stockholm, Sweden

The mathematical modeling of the diffusion and reaction of toxic compounds in mammalian cells is tough task due to their very complex geometry. The heterogeneity of the cell, particularly the cytoplasm, and the variation of the cellular architecture, greatly affects the behavior of these toxic compounds. Homogenization techniques have been implemented for the numerical treatment of the model. ...

Assessment of Hemodynamic Conditions in a-v Fistulas using CFD

A. K. Niemann1,5, S. A. Kock1, J. V. Nygaard2, E-T. Fründ3, S. E. Petersen4, and J. M. Hasenkam5
1 MR-center, Aarhus University Hospital Skejby, Aarhus, Denmark
2Interdisciplinary Nanoscience Center, Faculty of Science, University of Aarhus, Skejby, Denmark
3Dept. of Radiology, Aarhus University Hospital, "Aalborg Sygehus Syd", Aalborg, Denmark
4Dept. of Urology, Aarhus University Hospital Skejby, Aarhus, Denmark
5Dept. of Cardio-Thoracic and Vascular Surgery, and Clinical Institute, Aarhus University Hospital Skejby, Aarhus, Denmark

Using Computational Fluid Dynamics, different geometries of side-to-side a-v fistulas for hemodialysis access are evaluated. We created five CAD-models of fistulas with the length of the anastomosis varying from 5 to 15 mm. The five models were analyzed and evaluated using the k-ε turbulence application mode in COMSOL Multiphysics to determine if an optimal length of anastomosis exists. ...

Modelling Nutrient Transport in a Hollow-Fiber Membrane Bioreactor with Considerating the sub-Cellular Scale Mass Transfer

N. S. Abdullah1, D. B. Das2, and D. R. Jones1
1Department of Engineering Science, University of Oxford, Oxford, UK
2Department of Chemical Engineering, Loughborough University, Leicestershire, UK

Current bone tissue engineering protocols allow ex vivo growth of soft bone tissues in bioreactors. Recent experimental studies suggest that hollow fiber membrane bioreactors (HFMBs) may be used for growing 3-dimensional, clinically viable bone tissues. In order to facilitate the design of the HFMB for growing bone tissues, it is necessary to elucidate the quantitative relationships between cell ...

Dynamic Simulation Of Particle Self-Assembly Applied To Microarray Technology

V. Di Virgilio, A. Coll, S. Bermejo, and L. Castañer
Universitat Politecnica de Catalunya, Barcelona, Spain

In this work we want to explore some techniques, microfluidic and electrospray-ionization based, suitable for dynamic microarrays\' fabrication. The fabrication techniques are based on manipulation and self-assembly of selective coated micro and nanobeads. The simulation will include electro-osmotic flow, species transport, and electrostatics.

Computationally Assisted Design and Experimental Validation of a Novel ‘Flow-Focussed’ Microfluidics Chip for Generating Monodisperse Microbubbles

M. Conneely[1], V. Hegde[2], H. Rolfsnes[1], A. Mason[2], D. McLean[1], C. Main[1], F.J.D. Smith[2], W.H.I. McLean[2], P.A. Campbell[1]
[1]Carnegie Physics Laboratory, University of Dundee, Dundee, Scotland, United Kingdom
[2]Division of Molecular Medicine, University of Dundee, Dundee, Scotland, United Kingdom

Whilst initially developed as a diagnostic aid to improve echogenicity in ultrasound imaging, gas-filled lipid microbubbles are now emerging as a next generation \'theranostic\' tool in the medical arena. Here, their therapeutic potential has now been realized through their unique capability to deliver molecular species such as drugs and genes by means of disrupting the cell membrane in response ...

An Efficient Finite Element Analysis on an RF Structure Used to Evaluate the Effect of Microwave Radiation on Uveal Melanoma Cells

A. Dulipovici[1], D. Roman[2], I. Stiharu[2], and V. Nerguizian[1]

[1]École de technologie supérieure, Montreal, Quebec, Canada
[2]Concordia University, Montreal, Quebec, Canada

The use of Microwave/RF energy on cancer cells is explored for tumor ablation using medium power level ranging between a few Watts to about 50 Watts. In this research, low power levels, less than 100 mWatt, are used to evaluate the effect of this energy on Uveal melanoma cells by proliferation tests. The COMSOL simulation of the RF structure used to evaluate the radiation energy on ...

A Virtual Pharmacokinetic Model Of A Human Eye

L. Murtomäki, and S. Kotha
University of Helsinki, Centre for Drug Research, Helsinki, Finland

Drug therapy of the posterior part of an eye is very challenging. Yet, in USA alone, there are almost 2 million people affected by age related macular degeneration. When designing a strategy for controlled-release drug delivery, it is important to take into account of physiology, absorption, distribution, metabolism, and excretion properties of a drug. Therefore, the aims of this study are: 1) to ...

Shear Induced Detachment Of Microorganisms Attached To A Plane Wall

B. Boulbène, J. Morchain, and P. Schmitz
Université de Toulouse, NSA, UPS, INP, LISBP, Toulouse, France

We present numerical results involving microorganisms adhering to a plane surface submitted to a shear flow. The purpose is to have a better understanding of the removal mechanisms occurring during the cleaning in place of food processing equipments. The biological cell, i.e. the microorganism, is modelled as a rigid obstacle embedded in the bottom wall of the fluid domain. Shear induced ...

From customer requirement to product requirement with COMSOL

A.B. Nilsson
BD Medical - Medical Surgical Systems, Helsingborg, Sweden

Anders B Nilsson graduated M. Sc. in engineering physics from Lund University in Sweden. He has been working in the R&D department at BD Medical as principal engineer and project leader since 2005. He uses COMSOL for a wide range of functions, such as early concept development and qualification of products.

Material Characterization Method Development: From Education to Design Optimization

C. Morgan[1], N. Kenkare[1], M. Williams[2], A. Peterson[2], and D. Williams[2]
[1]Alcon Eye Care Division of Novartis R&D, Duluth, GA
[2]Alcon Eye Care Division of Novartis R&D and Georgia Institute of Technology Co-op Program, GA

Introduction of silicone hydrogel contact lens materials provided products of unprecedented capability to deliver oxygen to the eye during wear. One additional material characteristic of interest is the material’s permeability to ions. This paper discusses descriptive tools and optimization of an impedance method of characterizing ion permeability. A physical model of conductive paper with ...

Quick Search