A Method for Efficient Calculation of Diffusion and Reactions of Lipophilic Compounds in Complex Cell Geometry
Kristian Dreij, Qasim Ali Chaudhry, Bengt Jernström, Ralf Morgenstern, and Michael Hanke
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden
A general description of effects of toxic compounds in mammalian cells is facing several problems. Firstly, most toxic compounds are hydrophobic and partition phenomena strongly influence their behaviour. Secondly, cells display considerable heterogeneity regarding the presence, activity and distribution of enzymes participating in the metabolism of foreign compounds i.e. ...
E. Lacatus, M. A. Sopronyi, G. C. Alecu, A. Tudor
Polytechnic University of Bucharest, Bucharest, Romania
INFLPR -National Institute for Laser Plasma and Radiation Physics, Bucharest, Romania
For biocompatible prosthetics, from dental implants up to bone parts, manufacturers have to find the best way to correlate process parameters and the material properties as to meet the unique needs of individuals. Additive manufacturing techniques aim at creating complex biocompatible structures able to overcome the present shortfalls of the metal and metal alloys implants related to ...
A. Eed Olamat, U. Hofmann, B. Pohl, and N. Nkemasong
University of Lübeck, Institute for Signal Processing, Lübeck, Germany
In order to investigate the implantation of microprobes into brain tissue, we developed a finite-element and a physical model to replace real biological tissue for mechanical testing. Penetrating forces of a tungsten indenter into a layered structure was investigated with different indentation speeds. Numerical and physical model are in good correspondence to each other and reproduce measured ...
B. Jordan, and P. Müller
The specification of cell types and morphogenesis of many biological systems are regulated by the concentrations of signalling molecules. Many systems employ a pair of secreted short-range activators and long-range inhibitors, and these are widely used to generate complex patterns during development. However, the biophysical mechanisms that regulate the different ranges of activators and ...
J. Parikh, A. Kapela, N. Tsoukias
Biomedical Engineering Department, Florida International University, Miami, FL, USA
Localized calcium events in the endothelial cells (EC) can modulate smooth muscle cell (SMC) calcium (Ca2+) and membrane potential dynamics through release of endothelium derived hyperpolarizing and relaxing factors. Ca2+ levels in the smooth muscle cell (SMC) determine its contractile state.The underlying complex mechanism regulating the SMC Ca2+ levels and ultimately vessel tone remains poorly ...
A. Warning, A. K. Datta
Department of Biological & Environmental Engineering, Cornell University, Ithaca, NY, USA
Predictive food microbiology currently first requires experimental data for growth on fresh produce and then fitting an empirical or semi-empirical model to the data, making extrapolation to other conditions (temperature, type of produce) difficult. Herein, we develop a mechanistic model for the growth of human pathogenic bacteria (Escherichia coli O157:H7 and Salmonella spp.) on spinach using ...
D. Iber[1,3], Z. Karimaddini[1,3], E. Unal[1,2], D. Menshykau[1,3]
D-BSSE, ETH Zurich, Basel, Switzerland
DBM University of Basel, Basel, Switzerland
Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland
Mathematical Modeling has a long history in developmental biology. Advances in experimental techniques and computational algorithms now permit the development of increasingly more realistic models of organogenesis. In particular, 3D geometries of developing organs have recently become available. In this paper, we show how to use image-based data for simulations of organogenesis in the COMSOL ...
L. Saeeednia, H. Mehraein, F. Abedin, K. Cluff, R. Asmatulu
Department of Mechanical Engineering, Wichita State University, Wichita, KS, USA
Department of Bioengineering, Wichita State University, Wichita, KS, USA
Targeted drug delivery systems have been wildly studied in cancer therapy due to the toxicity of most of chemotherapeutic drugs. Nanoparticles can be attached to the small molecules of the drugs and serve as drug carriers to deliver the drug molecules into the area of interest. In this research, polymeric microspheres containing biodegradable poly(D, L-lactide-co-glycolide) (PLGA), magnetic ...
C. Nadovich[1, 2], W. D. Jemison, J. A. Stoute, C. Spadafora
Lafayette College, Easton, PA, USA
Clarkson University, Potsdam, NY, USA
Pennsylvania State University, Hershey, PA, USA
INDICASAT AIP, Ciudad del Saber, Panama
A computer controlled microwave exposure system and specialized applicators were constructed for the purpose of facilitating accurate observations of microwave radiation effects on uninfected and infected biological tissue in vitro and in vivo under different electromagnetic modalities and exposure configuration. To address diverse requirements, three different applicators were developed: a ...
Stochastic Diffusion of Calcium Ions Through a Nanopore in the Cell Membrane Created by Electroporation
O. Henao, V. Gómez, I. De La Pava, J. Sánchez 
Grupo Fisiología Celular y Aplicada, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia
We simulated the diffusion of calcium ions through a nanopore created in the cell membrane by electroporation, in presence and absence of the external electric field responsible of the membrane permeabilization. First we solved the set of coupled differential equations that describe the process of ionic diffusion in a 2D nanopore model using the AC/DC Module and the Transport of Diluted Species ...