Evaluation of Performance of Enzymatic Biofuel Cells with Microelectrode Arrays Inside a Blood Artery via Finite Element Approach
C. Wang, Y. Song
Florida International University, Miami, FL, USA
Enzymatic biofuel cells (EBFCs) are considered as a promising candidate for powering miniature implantable devices. In order to predict the performance in the human blood artery, we simulated a 3D EBFC chip with highly dense micro-electrode arrays. In this simulation using COMSOL Multiphysics®, we applied the 1) Michaelis Menten equation; 2) Nernst potential equation; 3) Navier Strokes velocity, ...
COMSOL Multiphysics® as a Tool for Reducing Animals in Biomedical Research: An Application in Dermatology
F. Rossi and R. Pini
Istituto di Fisica Applicata “Nello Carrara”, Consiglio Nazionale delle Ricerche, Firenze, Italy
In biomedical research the use of animal models gives rise to several ethical problems. COMSOL Multiphysics® may be used as a non-animal technique, very useful in overcoming all these concerns. In this presentation a particular application in dermatology is shown. Bioheat equation mode and diffusion approximation were used to design a theoretical model of blue LED light interaction with an ...
Temperature Excursions at the Pulp-Dentin Junction during the Curing of Light-Activated Dental Restorations
M. Jakubinek[1,2], C. Neill, C. Felix, R. Price[2,3], M. White[1,2]
Departments of Chemistry and Physics, Dalhousie University, Halifax, NS, Canada
Institute for Research in Materials, Dalhousie University, Halifax, NS, Canada
Department of Dental Clinical Sciences, Dalhousie University, Halifax, NS, Canada
Heat produced during the curing of light-activated dental restorations could damage the dental pulp. Given the prevalence of composite restorations and the importance of avoiding injury to the pulp, efforts should be made to minimize the temperature increase that occurs at the pulp-dentin junction during light-curing. In this investigation we develop and evaluate a COMSOL Multiphysics FEM tooth ...
Y. Song, and C. Wang
Florida International University, Miami, FL, USA
Enzymatic biofuel cells (EBFCs) are miniature, implantable power sources, which use enzymes as catalysts to perform redox reaction with biological fuels such as glucose. In this study using COMSOL Multiphysics, we use an EBFC chip, having three dimensional, highly dense micro-electrode arrays, fabricated by C-MEMS micro-fabrication techniques. Glucose oxidase (GOx) is immobilized on anodes for ...
R. Penjweini, M. M. Kim, T. C. Zhu
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA
Introduction: Singlet oxygen (¹O₂) has a critical role in the cell-killing mechanism of photodynamic therapy (PDT). Therefore, in this study, the distance-dependent reacted ¹O₂ is numerically calculated using finite-element method (FEM). Herein, we use a model [Ref. 1] that has been previously developed to incorporate the diffusion equation for the light transport in tissue and the ...
K. K. Sriperumbudur, P. J. Koester, M. Stubbe, C. Tautorat, J. Held, W. Baumann, and J. Gimsa
 University of Rostock, Chair of Biophysics, Gertrudenstr. 11a, 18057 Rostock, Germany
 Microsystem Material Laboratory, Department of Microsystems Engineering (IMTEK), University of Freiburg, Germany
In spite of its low throughput, Patch-Clamp is the established method for intracellular measurements of the transmembrane potential. To address this problem, we have developed new biosensor-chips with micro-structured needle electrodes (MNEs). MNE-penetration of single cells growing on the MNE-tips leads to a situation comparable to the whole-cell mode in classical Patch Clamp. MNE-penetration ...
U. Topaloglu, Y. Yan, P. Novak, P. Spring, J. Suen, and G. Shafirstein
 Department of Information Technology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Department of Otolaryngology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Thermal ablation in the head and neck requires accurate thermal dose delivery to target tissue while protecting the structure and function of nearby tissue and organs. In this study, we present a method that allows importing Computed Tomography (CT) scans to COMSOL, in order to model accurately the expected pathological outcomes prior to thermal ablation treatment. Thermal ablation of a virtual ...
M. Blaziková, J. Malínský, D. Stanek, and P. Herman
Faculty of Mathematics and Physics, Charles University, Prague, Czech Republic
Institute of Experimental Medicine, Prague, Czech Republic
Institute of Molecular Genetics, Prague, Czech Republic
Small nuclear ribonucleoprotein particles (snRNPs) are essential supramolecular complexes involved in pre-mRNA splicing, the process of post-transcriptional RNA modifications. The particles undergo complex assembly steps inside the cell nucleus in a highly dynamic compartment called the Cajal body. We have previously shown that the free diffusion model does not fully describe the snRNP motion ...
C. Morgan, N. Kenkare, M. Williams, A. Peterson, and D. Williams
Alcon Eye Care Division of Novartis R&D, Duluth, GA
Alcon Eye Care Division of Novartis R&D and Georgia Institute of Technology Co-op Program, GA
Introduction of silicone hydrogel contact lens materials provided products of unprecedented capability to deliver oxygen to the eye during wear. One additional material characteristic of interest is the material’s permeability to ions. This paper discusses descriptive tools and optimization of an impedance method of characterizing ion permeability. A physical model of conductive paper with ...
Dynamic Simulation of Bone Morphogenetic Protein Patterning in a 3D Finite-Element Model of the Danio Rerio Embryo
D. Umulis, and S. Lee
West Lafayette, IN
Zebrafish development of the dorsoventral axis relies on the spatiotemporal distribution of Bone Morphogenetic Protein (BMP) signaling, which is regulated by numerous secreted molecules such as Tolloid, Sizzled, and Chordin. The rich dorsal/ventral patterning network must achieve both spatial precision in the patterning of downstream targets and confernspatial precision at distinct time points in ...