Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Muscle-Electrode Interface Simulation

A. Altamirano, C. Toledo, A. Vera, R. Muñoz, and L. Leija
Centro de Investigacion y Estudios Avanzados
Instituto Politecnico Nacional

In this article, the aim is to study different types and forms of electromyography (EMG) electrodes, for bipolar configuration, and the electric interface with muscle phantom. COMSOL Multiphysics allows modeling shapes and contact surfaces. Surface and needle electrodes will be modeled. A number of different trials and combinations will be presented; exploring different geometric shapes and ...

Elucidating the Mechanism Governing the Cell Rotation Behavior Under DEP

G. Zhang[1], Y. Zhao[1], J. Brcka[2], J. Faguet[2], E. Lee[2]
[1]Clemson University, Clemson, SC, USA
[2]TEL U.S. Holdings, Inc., U.S. Technology Development Center, Austin, TX, USA

In our experiments with manipulating cells with DEP, we noted that some cells are constantly spining. By hypothesing that the cell spining is caused by the non-circular shape of the cell body and the off-centered location of its nucleus and that the rotation direction depends on the relative location of nucleus with respect to the electrical field, we found that the observed cell rotation was ...

Design of Microfluidic Device for Cellular Experiment Under Controlled Oxygen Tension

K. Funamoto[1], I.K. Zervantonakis[2], R.D. Kamm[2]
[1]Tohoku University, Sendai City, Miyagi, Japan
[2]Massachusetts Institute of Technology

Numerical simulation of oxygen tension was performed to develop a microfluidic device for three-dimensional real-time observation of cellular response under hypoxia. The optimal experimental condition was obtained through investigations of effects of parameters, such as device thickness and flow rates of media and gas, on oxygen tension.

Actively Controlled Ionic Current Gating In Nanopores

G. Zhang[1], S. Bearden[1]
[1]Clemson University, Clemson, SC, USA

It is necessary to understand and control nanopore behavior in order to develop biosensors for a variety of applications including DNA sequencing. The fluidics of nanopore devices we fabricated exhibits a range of interesting phenomena, such as enhanced conductance and current rectification. By electrically biasing nanopores, we were able to actively control the nanopore conductance in real time ...

Development of a Multiphase, Multispecies Droplet Evaporation Model for Optimization of Desiccation Preservation Techniques

A. Sinkevich[1], S. Bhowmick [1], M. Raessi[1]
[1]University of Massachusetts Dartmouth, North Dartmouth, MA, USA

Biopreservation deals with the protection and storage of complex biologics such as proteins, lipids, and recently, mammalian cells. One preservation method, known as lyopreservation, involves placing a biologic inside a water droplet with some type of sugar excipient (sucrose, trehalose, etc.) and drying the solution convectively. We are currently developing a model that couples the two-phase ...

Biofluid-Structural Interaction in Abdominal Aortic Aneurysm for Predicting Timeline to Rupture: The Effect of Hypertension and Aorta Wall Material Properties - new

K. Cluff[1], H. Mehraein[1], G. Jayakumar[2]
[1]Bioengineering, Wichita State University, Wichita, KS, USA
[2]Industrial & Manufacturing Engineering, Wichita State University, Wichita, KS, USA

An abdominal aortic aneurysm (AAA) is a bulge formed in the large blood vessels that supply blood to the abdomen, pelvis, and legs. A fluid structure interaction model was developed in a 3D aortic aneurysm model, which was constructed from abdominal CT scan images. Combining medical imaging and computational fluid dynamics (CFD) in a time dependent study allowed the determination of wall ...

Modelling the Response of Microdialysis Probes in Glucose Concentration Measurement

J.M. Gozálvez-Zafrilla[1], A. Santafé-Moros[1], J.L. Díez-Ruano[2], J. Bondia[2]
[1]Institute for Industrial, Radiophysical and Environmental Safety (ISIRYM) - Universitat Politècnica de Valencia, Valencia, Spain
[2]Instituto Universitario de Automática e Informática Industrial (AI2) - Universitat Politècnica de Valencia, Valencia, Spain

Microdialysis is a technique of continuous glucose monitoring in diabetic patients. In microdialysis, a saline serum is perfused into a microdialysis probe. Glucose pass from the plasmatic fluid through the porous membrane. The glucose concentration in the dialysate obtained is measured by an external analytical device. This preliminary work aimed to obtain a model to relate glucose ...

基于 DTI 纤维追踪和有限元力学模型的脑损伤轴突纤维损伤研究

李娜 [1], 李江红 [2]
[1] 中南大学湘雅三医院,长沙,湖南,中国
[2] 中车集团南车研究所,株洲,湖南,中国

研究头部损伤机理是对运动撞击中脑损伤进行预测的有效手段。数学模型是分析损伤实验数据、预测人员碰撞损伤程度的唯一方法,但现有的头部损伤有限元模型基于尸体实验数据,且忽略脑组织结构的各向异性。本项目旨在提出并实现一种以损伤生物力学为基础、结合磁共振扫描 DTI 的轴突走向信息的有限元力学模型。提取脑外伤前的弥散张量成像信息,实现深入到轴突水平有限元力学模型的建立,在有限元模拟中采用非线性超弹性力学模型,并植入 NSGAII 最优化方法对有限元模型的材料参数进行优化,从而提高模型的稳定性和计算精度;将计算预测结果与损伤后 DTI 的 FA 值所表现的轴突断裂情况进行验证, 探索活体环境下碰撞损伤中脑轴突的损伤性变化,从而获得脑外伤损伤程度与力学因素之间的关系,为脑外伤损伤程度的预测和脑外伤损伤标准的校正提供精确完整的信息。本项目的研究成果将在汽车碰撞的乘员防护设计上有重要的理论指导价值。 ...

Finite Element Modeling a Redox-Enzyme-Based Electrochemical Biosensor

Y. Huang[1], and A. Mason[1]
[1]Electrical and Computer Engineering, Michigan State University, East Lansing, Michigan, USA

This paper describes the modeling of an electrochemical biosensor embedded in a microfluidic channel to determine the concentration of a target biomolecule. The total amount of analyte in the sample can be calculated by integrating the analyte concentration over the duration of the peak current. The biosensor is constructed by immobilizing redox-enzyme on an interdigitated array (IDA) electrode ...

Modeling Inertial Focusing in Straight and Curved Microfluidic Channels

J. Martel[1], N. Elabbasi[2], D. Quinn[2], J. Bergstrom[2], M. Toner[1]
[1]BioMEMS Resource Center, Massachusetts General Hospital, Boston, MA, USA
[2]Veryst Engineering, Needham, MA, USA

Inertial focusing is a promising microfluidic technique for separating and concentrating cells of interest, processes routinely utilized in many medical procedures. This phenomenon is characterized by suspended particles in a flow spontaneously migrating across streamlines to equilibrium positions within a channel cross-section. We developed CFD models in COMSOL Multiphysics® to predict the ...