Institute for information and communication technologies, Bulgarian Academy of Sciences, Sofia, Bulgaria
Various haematological diseases, including leukaemia, are characterized by abnormal production of particular blood cells. Two important properties of haematopoietic stem cells (HSCs) are used in their therapy, namely: a) rapid migratory activity and ability to \'\'home\'\' to their niche in the bone marrow; b) high self-renewal and differentiation capacity, responsible for the production and ...
A. Di Carlo, V. Sansalone, A. Tatone, and V. Varano
Modelling and Simulation Lab, Università Roma Tre, Roma, Italy
Laboratoire de Mécanique Physique, Université Paris Est, Paris, France
DISAT, Università degli Studi dell’Aquila, L'Aquila, Italy
We present a mechanical model a growing spherical shell suitable for predicting the evolution of a Saccular Cerebral Artery Aneurysms (SCAA). It relies basically on the Kröner-Lee decomposition, used to describe the interplay between the current and the relaxed configuration of body elements. Rupture or stabilization of a SCAA are the end effect of a number of biological mechanisms, still poorly ...
Study of how electromagnetic characteristics of human abdomen affects B1+ distribution on 3T MR Imaging
GE Healthcare Japan Corporation, Japan
It was studied how the permittivity and the conductivity of humans had influence on the transmit B1 magnetic field distribution in the abdominal region. It was also studied how these electromagnetic characteristics affected the static RF shimming which is defined as RF shimming by applying amplitude scaled and phase shifted version of essentially the same RF signal to multiple transmit elements.
M.H. Oztop, and K.L. McCarthy
University of California, Davis, CA, USA
In this study, Whey Protein Isolate (WPI) gels of different thickness were soaked in solutions of pH 7.0 and mass uptake was recorded. A finite element model based on diffusion and deformed mesh application modes in COMSOL Multiphysics was developed. Deformed mesh application mode provided the opportunity to incorporate the moving boundaries. The moving boundaries were solved by introducing ...
Modeling Antibiotic Diffusion in a Microfluidic Biofilm Array to Study Bacterial Responses to Antibiotic Concentrations and Combinations
J. Deng, L. Villegas, L. Shor, A. Vázquez, A. Dhummakupt, P. Samson, and J.P. Wikswo
University of Connecticut, Storrs, CT, USA
Instituto Tecnológico y de Estudios Superiores de Monterrey, Monterrey, Mexico
Vanderbilt University, Nashville, TN, USA
Bacteria within a biofilm typically exhibit higher resistance to antibiotic therapy due to mass transport resistance of the biofilm matrix and/or reduced metabolic activity of cells living within the biofilm interior. The objective of this research was to develop a high-throughput experimental and modeling approach to investigate the effects of colony spacing and concentration on the ...
J. Stang, B. Fowlkes, M. Moghaddam, O. Kripfgans, and P. Carson
University of Michigan, Ann Arbor, MI, USA
A transcutaneous thermal therapy system is being developed for the targeted treatment of breast cancer cells using focused microwaves as an adjuvant to surgery, radiation, chemotherapy, and high intensity focused ultrasound (HIFU). Prior imaging studies are used to ascertain the material properties of the breast tissue, and this data is incorporated into a COMSOL Multiphysics model. Time ...
S. Boukhris, M. Denton, and Y. Feng
Computational Bioengineering and Control Lab, University of Texas at San Antonio, San Antonio, TX
TASC, Inc. Biomedical Sciences and Technology Dept., Ft. Sam Houston, TX
The use of lasers in the military and everyday life is growing each year. The purpose of the current research is to take full advantage of this new spatially-resolved thermal data to construct a mathematical and numerical model for laser-induced damage using COMSOL Multiphysics. The microthermography data were extracted for vertical and horizontal lines through the laser-exposed area of cell ...
C. Buffinton, P. Rogerson, and D. Ebenstein
The effects of calcifications on arterial wall stress have been largely ignored, in part because the material properties of the calcified areas were taken to be the same as the fibrous plaque, and in part because they are often assumed to have a stabilizing influence. Recent measurements suggest that their stiffness should be more similar to bone. A computational model is indicated for this ...
T. Merrill, and A. La Barck
Rowan University, Glassboro, NJ, USA
Reperfusion injury is caused by the rapid restoration of blood flow to oxygen-starved tissue. The model will simulate pulsatile blood flow. A separate 2-dimensional axisymmetric straight tube model will be constructed to simulate the pulsating angioplasty balloon within the flow path. Outlet flow profiles from the straight tube model will then be used as the inlet condition for the ...
Multiphysics Modeling of Applied Stresses and Strains in an Isolated Biologic Cell During Microfluidic Manipulation
Y. Liang, A. Saha, Z. Shi, R. Marcus, and S.S. Kohles
Central State University, Wilberforce, OH, USA
Portland State University, Portland, OR, USA
In order to test the hypothesis that a controlled external mechanical stimulus may affect cellular regeneration or degeneration, we developed a three-dimensional computational model to explore the applications of a unique micromechanical environment in COMSOL. Recently, experimental stresses have been applied to living cells suspended by an optical trap within microchannel cross-junctional flows. ...