Computationally Assisted Design and Experimental Validation of a Novel ‘Flow-Focussed’ Microfluidics Chip for Generating Monodisperse Microbubbles
M. Conneely, V. Hegde, H. Rolfsnes, A. Mason, D. McLean, C. Main, F.J.D. Smith, W.H.I. McLean, P.A. Campbell
Carnegie Physics Laboratory, University of Dundee, Dundee, Scotland, United Kingdom
Division of Molecular Medicine, University of Dundee, Dundee, Scotland, United Kingdom
Whilst initially developed as a diagnostic aid to improve echogenicity in ultrasound imaging, gas-filled lipid microbubbles are now emerging as a next generation \'theranostic\' tool in the medical arena. Here, their therapeutic potential has now been realized through their unique capability to deliver molecular species such as drugs and genes by means of disrupting the cell membrane in response ...
A. Dobrinsky, M. Shatalov, M. Shur, R. Gaska
Sensor Electronic Technology, Columbia, SC, USA
Deep Ultraviolet Light Emitting Diodes (DUV LEDs) are presently operating at a relatively low efficiency, thus large amount of LED driving power is dissipating in heat. Thermal heating degrades LED performance and decreases LED’s lifetime. The degradation of DUV LED devices with temperature increase makes thermal management a key issue for DUV LEDs. We present a thermal analysis of DUV LED ...
OSRAM SYLVANIA, Beverly, MA, USA
COMSOL Multiphysics is used to simulate natural convection and its impact on peak operating temperatures of solid-sate lighting in thermally adverse conditions. PDE modes in the general form are used in conjunction with a thin-surface conduction formulation in the weak form. COMSOL is used to predict both temperatures and heat flows through numerous components of the configuration. Model ...
T.C. Zhu, B. Liu, X. Liang
University of Pennsylvania, Philadelphia, PA, USA
Singlet oxygen (1O2) is the major cytotoxic agent during photodynamic therapy (PDT). A previously developed model that incorporates the diffusion equation for the light transport in tissue and the macroscopic kinetic equations for the generation of the singlet oxygen, can be used to numerically calculate the distance-dependent reacted 1O2 using finite-element method (FEM). The formula of reacted ...
Numerical and Experimental Evaluation for Measurement of a Single Red Blood Cell Deformability Using a Microchannel and Electric Sensors
Kyoto University, Kyoto City, Kyoto, Japan
An electric micro-resistance sensor that can continuously measure the deformability of a single red blood cell (RBC) in a microchannel and a numerical model that can simulate the resistance and capacitance of the cell membrane and cytoplasm are developed and improved. The resistance signal pattern between the electrodes is measured to evaluate the feasibility of the present sensor, using the ...
D. Krapohl, S. Loeffler, A. Moser, and U.G.Hofmann
Institute for Signalprocessing, University of Luebeck, Lübeck, Germany
Institute for Neurology, University of Luebeck, Lübeck, Germany
Department of Information Technology and Media, Mid Sweden University, Sundsvall, Sweden
Deep Brain Stimulation (DBS) has been established as an effective treatment for Parkinson's disease and other movement disorders. The stimulation is currently administered using tetrode-macroelectrodes that target the Subthalamic Nucleus (STN). This often leads to side effects which bias the surrounding areas, e.g. the speech centre. Targeting a specific brain region can better be achieved with ...
Nardinocchi, P.1, Teresi, L.2
1 Università degli Studi di Roma ”La Sapienza”
2 Università degli Studi Roma Tre
The present study addresses the evolution of the smooth muscles of which blood-vessel walls are composed, in the framework of a continuum model concerning material remodeling presented in . By material remodeling we mean all those microscopic processes whose effects emerge at macroscopic level as evolution of the relaxed state of a body, and, as consequence, of its actual configuration. We ...
Amimer, A.1, 2, Mandin, P.3, Lincot, D.3, Horner, O.1
1 EDF R&D, Département MMC, Moret-sur-Loing, France
2 Ecole Nationale Supérieure de Chimie de Paris, Paris, France
3 Ecole Nationale Supérieure de Chimie de Paris, UMR 7575, Paris, France
Flow Accelerated Corrosion (FAC) of carbon steel has been studied world-wide for more than twenty years and is now fairly well understood. The influence of several parameters like water chemistry (pH, dioxygen content), temperature, hydrodynamic or mass transfer conditions (flow velocity, geometry) and steel composition on the corrosion kinetics has been demonstrated both theoretically (“Berge ...
Espinoza Vallejos, P.A., Duston, C.
Technology Assessment and Transfer
FEMLAB was used to aid in the design of a novel temperature management system. The system under consideration is a heat sink consisting of a carbon foam block brazed to the inside of an aluminum enclosure. The high thermal conductivity carbon foam is structurally reinforced and filled with a phase change material. A phase change material (PCM) is a substance which releases a large amount of ...
EIHES, Ecole d’Ingénieurs de Genève
Electron interferometry using the Aharonov-Bohm (AB) effect finds many applications in industrial areas such as future nanocomputer technologies, physical random number generators, electron phase microscopy and holography, to name just a few. The presence of a confined magnetic field surrounded by the interferometer arms, as originally proposed by Aharonov and Bohm is however a source of ...