Brain edema is one of the most common consequences of serious traumatic brain injuries which is usually accompanied with increased Intracranial Pressure (ICP) due to water content increment. A three dimensional finite element model of... COMSOL Conference 2009, Milan X.G. Li1 , H. von Holst1 2 , J. Ho1 , and S. Kleiven1 1 Division of Neuronic Engineering, KTH, Stockholm, Sweden 2 Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
Stroke is caused by an interruption of brain blood supply and is one of the leading causes of death and disability. A mild reduction of 2-5°C in tissue temperature through hypothermia has shown reduced tissue infarct size, increased... COMSOL Conference 2012, Boston R. Sikorski1 , T. Merrill1 1 Rowan University, Glassboro, NJ, USA
To evaluate the possibility of achieving drug concentration levels required for localized immunosuppression and to optimize sustained, local delivery within small, subcutaneously implanted, prevascularized biohybrid devices designed to... COMSOL Conference 2007, Boston N. Bocca, C. Ricordi, N. S. Kenyon, P. Latta, and P. Buchwald Diabetes Research Institute, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA
Study of neurons plays a key role in the fields of basic and medical research aiming at the development of electrically active implants. The Fitzhugh-Nagumo equations are used to model and simulate the spike generation and propagation in... COMSOL Conference 2009, Bangalore R. Appali1 , S. Petersen1 , J. Gimsa2 , and U. Rienen1 1 Institute of General Electrical Engineering, Chair of Electromagnetic Field Theory, University of Rostock, Germany 2 Institute of Biology, Chair of Biophysics, University of Rostock, Germany
We present a preliminary investigation of a Nanoneedle biosensor as an ultra sensitive and localized impedance biosensor using COMSOL.This preliminary study was performed to prove the feasibility of the impedance biosensor for detection... COMSOL Conference 2007, Boston H. Esfandyarpour1,2, A. Maiyegun1, and R. W. Davis2 1Center for Integrated Systems, Department of Electrical Engineering, Stanford University, Stanford, CA, USA 2Stanford Genome Technology Center, Stanford, CA, USA
To support high frequency transmission, the mammalian middle ear construction is unique. The middle ear bones are connected through two mobile joints, the malleus-incus joint (MIJ) and the incudostapedial joint (ISJ). These synovial... COMSOL Conference 2010, Boston H. Cai, R.P. Jackson, C. Steele, and S. Puria Stanford University, Stanford, CA, USA
This paper proposes a FEM model for a segment of a nervous cell axon, which takes into account, through the so called Hodgkin-Huxley equations, the non linear and time varying dynamics of the membrane surrounding it. A combination with... COMSOL Conference 2009, Milan S. Elia1 , P. Lamberti1 , and V. Tucci1 1 Dept. of Electrical and Information Engineering, University of Salerno, Salerno, Italy
Ferrofluids are stable colloidal suspensions of nanosize magnetic particles in an organic or aqueous medium. Suspending nonmagnetic particles within a ferrofluid has led to numerous new areas of study. The simultaneous action of magnetic... COMSOL Conference 2007, Boston A. Kose, B. Fischer, and H. Koser Electrical Engineering Department, Yale University, New Haven, CT, USA
The aim of the poster is to present a coupled 2D mathematical model to predict the evolution of drug concentration - in the cornea and in the anterior chamber of the eye - when therapeutic lenses are used (Figure 1). The mathematical... COMSOL Conference 2012, Milan P. Silva1 , J.A. Ferreira2 , P. de Oliveira2 1 Coimbra Institute of Engineering, CMUC, Coimbra, Portugal 2 Department of Mathematics University of Coimbra, CMUC, Coimbra, Portugal
A general description of effects of toxic compounds in mammalian cells is facing several problems. Firstly, most toxic compounds are hydrophobic and partition phenomena strongly influence their behaviour. Secondly, cells display... COMSOL Conference 0, Kristian Dreij1 , Qasim Ali Chaudhry2 , Bengt Jernström1 , Ralf Morgenstern1 , and Michael Hanke2 1 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden 2 School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden
The complex behavior of biological prosthetic heart valves was simulated. A multiphysics computational approach was adopted using different modules of COMSOL Multiphysics: the LiveLink(TM) interface was used to exchange the valve geometry... COMSOL Conference 2012, Milan A. Avanzini1 , D. Battini1 , M. Berardi1 1 Università degli Studi di Brescia, Brescia, Italy
In the developing embryo, neurons form connections by projecting axons to appropriate target areas. The projection process includes neurite elongation, resulting from the assembly of new cytoskeletal material at the free end of the axon,... COMSOL Conference 2012, Milan G. Naldi1 , G. Aletti1 , P. Causin1 1 Dipartimento di Matematica ‘F. Enriques’, Università degli Studi di Milano, Milano, Italy
The technique of magnetic drug targeting binds genetic material or drugs to superparamagnetic nanoparticles and accumulates them via an external magnetic field in a target region. However, it is still a challenge for this approach to... COMSOL Conference 2010, Paris A. Heidsieck, and B. Gleich Zentralinstitut für Medizintechnik, TU München, München, Germany
Mechanical tissue properties are required for reliable numerical models of the vocal folds. In this study, criteria for determining the compatibility of tissue property values obtained from independent studies are presented.Two methods... COMSOL Conference 2007, Boston D. D. Cook1, E. Nauman1, and L. Mongeau2 1Department of Mechanical Engineering, Purdue University, West Lafayette, IN, USA 2Department of Mechanical Engineering, McGill University, Montréal, QC, Canada
Implantable Collagen sponges are used in Spinal Surgery as Drug Delivery Scaffolds. An optimal concentration of growth factor that strikes a balance between bone growth and adverse diffusion effects is difficult to find. The porous sponge... COMSOL Conference 2011, Boston A. Sun, and S. Murray Dept. of Biomedical Engineering UCLA, Los Angeles, CA
The use of Microwave/RF energy on cancer cells is explored for tumor ablation using medium power level ranging between a few Watts to about 50 Watts. In this research, low power levels, less than 100 mWatt, are used to evaluate the... COMSOL Conference 2009, Boston A. Dulipovici1 , D. Roman2 , I. Stiharu2 , and V. Nerguizian1 1 École de technologie supérieure, Montreal, Quebec, Canada 2 Concordia University, Montreal, Quebec, Canada
In this paper we introduce a elastic and hyperelastic model to describe the pressure dependent material stress in joint cartilage. We used the pressure dependent E-modulus E = f(s) to calculate the material stress. E = f(s) is a degree 4... COMSOL Conference 2011, Stuttgart T. Reuter, and M. Hoffmann fzmb GmbH Research Centre of Medical Technology and Biotechnology Bad Langensalza, Germany
In this paper we introduce a elastic and hyperelastic model to describe the biomechanics of joint cartilage. As biomechanical property we calculated the pressure dependent E-modulus E = f(s) to describe the dependence of the biomechanical... COMSOL Conference 2011, Stuttgart T. Reuter, and M. Hoffmann fzmb GmbH Research Centre of Medical Technology and Biotechnology Bad Langensalza, Germany
In this paper, we develop an inverse finite-element model for estimating elasticity of the arterial wall. We model the blood flow using COMSOL’s Structural Mechanics module, and use the resulting nonlinear functions corresponding to the... COMSOL Conference 2007, Boston A. Jeremic, and T. Gadkari McMaster Univerisity, Hamilton, ON, Canada
This paper deals with a numerical investigation on sliding door and people moving effects on the indoor climate of a standard ISO5 class OT with an ultraclean air filter system and a total ceiling unidirectional diffuser. A simple method... COMSOL Conference 2012, Milan C. Balocco1 1 Dipartimento di Energetica, Università di Firenze, Firenze, Italy
