Bioengineering Blog Posts
Simulating Analog-to-Digital Microdroplet Dispensers for LOCs
Microfluidic biochips have a variety of applications and are valued for their low cost, fast response time, and high efficiency. In the paper “Design and Simulation of High-Throughput Microfluidic Droplet Dispenser for Lab-on-a-Chip Applications”, which was presented at the COMSOL Conference 2014 Boston, researchers designed a microfluidic biochip with an analog-to-digital converter. They used COMSOL Multiphysics software to understand the mechanism of the device and verify its function.
How can you use an electric field to control the movement of electrically neutral particles? This may sound impossible, but in this blog entry, we will see that the phenomenon of dielectrophoresis (DEP) can do the trick. We will learn how DEP can be applied to particle separation and demonstrate a very easy-to-use biomedical simulation app that is created with the Application Builder and run with COMSOL Server™.
Biomechanical Model Evaluates Human Response to Vibrations
Depending on their magnitude and frequency, vibrations can be a source of discomfort and even pain for the human body. The impact of these vibrations is surely felt, but wouldn’t it be interesting to visualize how different parts of the human body respond when placed in such an environment? We introduce you to a multibody model that enables you to analyze the body’s dynamic response to vibrations.
Acoustic Levitation Puts a Pure Spin on Medicine Fabrication
Engineers from Argonne National Laboratory used multiphysics simulation and trial-and-error prototyping to optimize the effectiveness of an acoustic levitator for medical fabrication.
Understanding Drug-Eluting Stents at Boston Scientific
Cardiovascular disease is a condition where the arteries in the heart are blocked by plaque. Narrowed arteries can restrict blood flow and cause chest pain and shortness of breath. Bare metal stents can be used to resolve the problem, but excessive tissue can grow over them and narrow the artery again (a process called restenosis). Engineers at Boston Scientific are using simulation to understand the release mechanisms in drug-eluting stents, which can be used to prevent this excess cell growth.
Modeling Bone Strength Using Isotropic and Anisotropic Materials
The question of exactly how strong living bones are poses many important considerations for the medical industry. There is not currently a single-purpose device in the field to test bone strength. However, it is possible for researchers to get measurements of bone strength by modeling the entire makeup of the bone and using multiphysics simulation to perform stress and strain analyses. Simulating bone strength starts with a simple map of the external topology of the bone and then delves into […]
Optimizing Dialyzer Design Using Multiphysics Simulation
A while back, I had the opportunity to speak with Steven Conrad, a critical care physician at the Louisiana State University (LSU) Health Science Center in New Orleans. Not only is Dr. Conrad a physician as well as a professor at LSU, he’s also a biomedical engineer who uses finite element analysis (FEA) to conduct research on the design of dialyzers. Dr. Conrad uses COMSOL Multiphysics to gain a deeper understanding of the physics behind these devices, and to create […]
Modeling an Accurate Drug Delivery Device
There are many different routes through which drugs and other medications can be delivered into a patient’s body during treatment. These include topographical ointments, pills, vaporizers, and injection systems, among others. Many of these drug delivery systems require an enormous amount of precision when it comes to the location, timing, concentration, and amount of the drug to be administered. This is where simulation can be a big help, as it can allow for the modeling of each of these aspects […]
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