June 2, 2022 10:00–16:30 CEST

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COMSOL Day: Biomedical Technologies

See what is possible with multiphysics simulation

Modeling and simulation methods, such as computational fluid dynamics (CFD) and structural analysis, have been used for quite some time for the analysis of biomedical devices. Multiphysics analysis, on the other hand, is relatively new for understanding, designing, and optimizing devices and processes in biomedical technology.

Biomedical technologies encompass many different applications involving multiple coupled physical phenomena — or multiphysics, which is best described by systems of partial differential equations. These range from tumor ablation using RF waves that create localized heat sources to the electrophoretic separation of red blood cells in microfluidics applications.

COMSOL Day: Biomedical Technologies will focus on how modeling and simulation aid in designing biomedical devices and understanding the underlying physical phenomena of these devices. Parallel sessions will focus on: fluid flow and microfluidics, electromagnetics and acoustics applications, biochemical sensors, and bioheating. Experienced users from industry will present their simulation work and COMSOL engineers will hold several technical sessions throughout the day.

Schedule

9:30
Registration
10:00
Welcoming Remarks
10:05

This year, the global medical devices market has been valued at an estimated $450 billion USD, with a 5–6% year-on-year growth projected for the next several years. Modeling and simulation are integral to developing new and improving existing medical device designs. The best simulation software platforms for advancing medical device design are those that have built-in capabilities to handle the multiphysics phenomena that underpin the wide range of device applications.

This session will touch upon some of the key applications and physics phenomena within this industry and then focus on the workflow that can be used within a biomedical device organization to fulfill its modeling and simulation goals.

This workflow involves the three main tools for product design development within COMSOL Multiphysics®:

  • Model Builder: Functionality for building the sophisticated models used to understand, design, and optimize biomedical devices
  • Application Builder: Functionality for creating specialized apps that encapsulate full-scale models and limit user access to only a few of the model's input and output fields
  • Model Manager: A database system for managing model and app development, collaboration between different model developers and with other units of an organization, and simulation data.
10:30
Q&A/Break
10:45
Keynote Speaker
11:05
Q&A/Break
11:15
Bioheating of Tissue
Ultrasound and Hearing Aids in Biomedical Technologies
11:45
Q&A/Break
12:00

Tech Lunches are informal sessions where you can interact with COMSOL staff and other attendees. You will be able to discuss any modeling-related topic that you like and have the opportunity to ask COMSOL technology product managers and applications engineers your questions. Join us!

12:30
Break for Lunch
13:10
Welcome Back: Some Useful Resources
13:15
Electromagnetics Applications Within Biomedical Technologies

The use of electromagnetic (EM) therapy in medical devices is not just constrained to bioheating; other applications include pacemakers, neuroscience applications such as brain, spinal nerve, and other nerve stimulation, and treating chronic pain and bladder control. Added to this list is the newly popular area of pulsed-field ablation (PFA).

COMSOL Multiphysics® provides all the tools you need to model such applications, regardless of your role in the medical device design, manufacturing, and process industry. The software caters to those modeling the underlying physics of the devices, design engineers, and even lab and field technicians and medical doctors.

This session will summarize a number of the features in COMSOL Multiphysics® and the AC/DC Module for modeling EM applications in biomedical technologies. It will also touch upon how the software can be used to create intuitive and specialized apps that can be used by all within the industry — not just modeling specialists.

Microfluidics and Separation in Biomedical Technologies
13:45
Q&A/Break
14:00
Panel Discussion
14:30
Q&A/Break
14:45
Keynote Speaker
15:05
Q&A/Break
15:15
FDA Blood Pump Validation

CFD modeling has been used extensively to simulate hemodynamics within blood-contacting medical devices. Using it in place of physical testing methods allows device developers to accelerate the development cycle, reduce costs, and validate device safety and effectiveness without exposing patients to unproven medical device prototypes.

The FDA routinely advises on using modeling and simulation to predict clinical outcomes, inform clinical trial designs, and support evidence of effectiveness. To this end, they have developed two benchmark models of the fluid flow in a nozzle and a centrifugal blood pump.

In this session, we will demonstrate a frozen rotor study based on an FDA-specified pump geometry using the CFD Module and Mixer Module add-ons to the COMSOL Multiphysics® software. In the study, a Newtonian fluid was used to describe blood flow, where a k-Ɛ turbulence model was used to obtain a good initial fluid flow solution for the shear stress transport (SST) model. We will also show how the study was validated against FDA-published benchmark data from computational studies and in vitro experiments.

Biochemical Sensors and Tests
15:45
Q&A/Break
16:00
Concluding Remarks

COMSOL Speakers

Jean-Marc Petit
Business Development Manager

Jean-Marc Petit joined COMSOL France in 2003 and is now in charge of business development. He holds a PhD in physics from the University of Orsay at CEA Saclay. He conducted research at ESRF and contributed to R&D at L'Oréal.

Colas Joannin
Technical Support Manager

Colas Joannin is a graduate engineer from École Centrale de Lyon and obtained a PhD in non-linear dynamics working for the Safran group. He manages technical support and training courses activities at COMSOL France.

Phil Kinnane
Senior VP of Sales
Kirill Shaposhnikov
Senior Developer, Acoustics

Kirill Shaposhnikov works at COMSOL as a development engineer in the acoustics group. He has a degree in applied mathematics from South-Russian State Polytechnic University and a PhD in mechanical engineering from the Vienna University of Technology. His interests focus on applied mathematics, mathematical physics, and numerical analysis.

Anna Juhasz
Technical Support Engineer

Anna Juhasz works with global technical support at COMSOL's Swedish office, where she specializes in Electromagnetics. Before joining COMSOL in 2004 she received her masters in engineering physics from Royal Institute of Technology in Stockholm.

Siva Sashank Tholeti
Senior Applications Engineer

Siva Sashank Tholeti is an applications engineer at COMSOL. He received his PhD in aeronautics and astronautics from Purdue University. His areas of interest include CFD, plasma-enhanced aerodynamics, plasma physics, propulsion, and multiphysics problems.

Niloofar Kamyab
Senior Applications Engineer

Niloofar Kamyab is a senior applications engineer at COMSOL with a focus on electrochemistry, including batteries and fuel cells. She received her PhD in chemical engineering from the University of South Carolina, where her research focused on the mathematical modeling of battery systems.

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COMSOL Day Details

Local Start Time:
June 2, 2022 | 10:00 CEST (UTC+02:00)
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Invited Speakers & Panelists

Marc-Antoine Lafay Air Liquide

Marc-Antoine Lafay is an engineer focused on mathematical and mechanical modeling. He also holds a PhD in computational fluid dynamics. For 12 years, he worked in the military and civil nuclear industries before joining the Healthcare branch of the Air Liquide group more than 6 years ago.

Pascal Mailley CEA

Dr. Pascal Mailley is the director of research at CEA and is currently the head of research for the CEA-Leti health division. He is currently working on electrochemical sensors for environmental and medical applications. He obtained an MSc in material engineering (1992) and a PhD in electrochemistry (1995) from the University of Grenoble in France. After his PhD, Dr. Mailley worked for two years in the pharmaceutical industry on the development of electrically assisted transdermal drug delivery devices before joining the University of Ulster in Northern Ireland as a lecturer, where he developed biosensors for food analysis and medical electrodes for implant and monitoring. Before joining the CEA-Leti health division, he worked for thirteen years as a lecturer at the University of Grenoble. During this period, his research projects were dedicated to the design of bioelectronic devices, the use of new carbon materials (nanotubes, diamond, graphene, and electronically conducting polymers) for the design of analytical platforms, and the development of new electrochemical concepts. He is author or coauthor of 85 publications (with an h-index of 29) and 13 patents in bioelectronics, biosensors, and surface chemistry.

Elisabeth Brusseau National Center for Scientific Research (CNRS)

Elisabeth Brusseau received her PhD in 2000 from the Institut National des Sciences Appliquées de Lyon (INSA Lyon) in France. She then joined the Experimental Echocardiography research group of the Thoraxcenter at Erasmus Medical Center in Rotterdam, the Netherlands, with a postdoctoral position. Since 2002, she has been a National Center for Scientific Research (CNRS) researcher, working at the CREATIS medical imaging laboratory in Lyon, France, as part of the Ultrasound Imaging team. Her main research interests include elastography, signal and image processing, and tissue characterization.