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See How Multiphysics Simulation Is Used in Research and Development

Engineers, researchers, and scientists across industries use multiphysics simulation to research and develop innovative product designs and processes. Find inspiration in technical papers and presentations they have presented at the COMSOL Conference. Browse the selection below or use the Quick Search tool to find a specific presentation or filter by application area.

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Bioscience and Bioengineering

Toward Nano-Scale Scanning Electrochemical Microscopy of Single Live Cells by Means of the COMSOL Multiphysics® software

Z. Ding [1], F. P. Filice [1], M. S. M. Li [1],
[1] Department of Chemistry, University of Western Ontario, London, ON, Canada

Scanning Electrochemical Microscopy (SECM) is a powerful noninvasive analytical technique employed in a variety of applications ranging from electrochemical characterization of material surfaces, to bioanalytical characterization of single live cells [1]. When applied to live cells, SECM ... Read More

Simulator for the Development of Electromagnetic Heart Assist Devices

D. G. Hurd [1],
[1] Iowa State University, Ames, IA, USA

Every year, in the United States alone, more than 40,000 infants are born with congenital heart defects (CHD) and an additional 550,000 adults are diagnosed with heart failure. Every year, $110 billion is spent on treating heart attacks and $20-39 billion on heart failure in the US. The ... Read More

Nonhomogeneous Heat Transfer Simulation Using a Female Human Model

M. Castellani [1], T. Rioux [1], X. Xu [1],
[1] U.S. Army Research Institute of Environmental Medicine, Natick, MA, USA

Previously researchers have modeled the human body using CAD software to create geometries that are approximately the same shape as the human body. While these CAD designs appear similar, they do not account for complex organ anatomy or sudden changes at the skin surface. Now, the human ... Read More

Mathematical Modeling of Drug Transport in Brain Tumors

Y. Guo [1], M. O. Bernabeu [2], C. D. Arvanitis [1],
[1] Georgia Institute of Technology, Atlanta, GA, USA
[2] University of Edinburgh, Edinburgh, United Kingdom

Blood-brain and blood-tumor barriers (BBB and BTB) constitute a major obstacle to the transport of therapeutics in brain tumors. Focused ultrasound (FUS), when combined with circulating microbubbles, provides a noninvasive method to locally and transiently disrupt the BBB/BTB. ... Read More

Effect of Duty Cycle Variation on Acoustic Pressure Field Simulation in an Ultrasound Bioreactor

A. Rahimi [1], J. Crapps [1], N. Case [1]
[1] Biomedical Engineering, Saint Louis University, Saint Louis, MO, USA

Daily application of a low intensity pulsed ultrasound (LIPUS) regimen has been shown to have positive effects on bone fracture healing. Although LIPUS treatment can induce cellular responses supporting bone repair, the underlying mechanisms are not well understood. Further in vitro ... Read More

A Partial Verification of a COMSOL® Example Problem on the Fluid-Structure Interaction in a Network of Blood Vessels

J. T. Fong [1], A. Heckert [1], J. J. Filliben [1]
[1] National Institute of Standards & Technology, Gaithersburg, MD, USA

Finite element method (FEM)-based solutions are known to contains errors and uncertainties due to at least four mathematical (M) and four physical (P) sources, namely, (M-1) mesh density or degrees of freedom, (M-2) mesh element types, (M-3) mesh quality such as mean aspect ratio, (M-4) ... Read More

A Microfluidic Platform for Electrochemical Concentration and Detection

C. F. Ivory [1], D. E. Molina [1],
[1] Washington State University, Pullman, WA, USA

A poly(methyl methacrylate) (PMMA) microfluidic platform with a hot-embossed microchannel, 150 mm wide and 20 mm deep, was developed for multiple purpose detection using electrochemical methods. This device is able to accommodate a three-electrode system encased in 1/16" diameter PEEK ... Read More

A Numerical Heat Transfer Analysis on an Implantable Phase-Change Actuated Peristaltic Micropump

F. Forouzandeh [1], D. A. Borkholder [1],
[1] Rochester Institute of Technology, Rochester, NY, USA

Advances in protective and restorative biotherapies have created new opportunities to address vestibular disorders, deafness, and noise induced-, sensorineural-, and age-related hearing loss. Controllable and implantable drug delivery micropumps are essential for therapy development in ... Read More

Simulating Organogenesis in COMSOL Multiphysics®: Comparison of Methods for Simulating Branching Morphogenesis

L. D. Wittwer [1], M. Peters [1], S. Aland [2], D. Iber [1],
[1] ETH Zürich, Zurich, Switzerland
[2] University of Applied Sciences, Dresden, Germany

Organogenesis, the genesis of organs during embryonic development, is an active research field involving biologists, mathematicians and computational researchers. Fundamental questions of the formation of shape and the control of growth are still not answered. We focus on the development ... Read More

Electroceutical Modeling with Advanced COMSOL® Techniques

K. Carlson [1,][2], J. Begnaud [3], J. L. Shils [4], S. Dokos [5], L. Mei [1,][2], J. E. Arle [1,][2]
[1] Beth Israel Deaconess Medical Center, Boston, MA, USA
[2] Harvard Medical School, Boston, MA, USA
[3] Livanova Neuromodulation, Houston, TX, USA
[4] Rush Medical Center, Chicago, IL, USA
[5] University of New South Wales, Sydney, NSW, Australia

Neuromodulation is the use of electromagnetic fields to modulate the human nervous system, typically to treat neurological disorders. Electroceuticals is an ambitious program to modulate any nerve, anywhere, anytime, for any reason — to treat disease, disorders, and enhance or interface ... Read More

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