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See How Multiphysics Simulation Is Used in Research and Development

Engineers, researchers, and scientists across industries use multiphysics simulation to research and develop innovative product designs and processes. Find inspiration in technical papers and presentations they have presented at the COMSOL Conference. Browse the selection below or use the Quick Search tool to find a specific presentation or filter by application area.

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Bioscience and Bioengineering

Simulating Spiking Neurons Using a Simple Mathematical Model

S. Kirigeeganage [1], J. Naber [1], D. Jackson [1], R. Keynton [1], T. Roussel [1],
[1] University of Louisville, Louisville, KY, USA

This paper utilizes COMSOL Multiphysics® software and the Application Builder to simulate neurological responses in nerve axons due to external electrical stimuli. The AC/DC Module of the COMSOL® software is first used to solve the Maxwell's equations. Then the results from the Maxwell's ... Read More

Using COMSOL Multiphysics® Software for Benchmarking Problems in Cell Migration

M. Nickaeen [1], I. L. Novak [1], A. Mogilner [2], B. M. Slepchenko [1],
[1] Richard D. Berlin Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, CT, USA
[2] Courant Institute and Department of Biology, New York University, New York, NY, USA

A recently published conservative algorithm for simulating reactions and transport in moving domains have been extended to models in which cell kinematics are coupled with intracellular dynamics. For this, the method that combines a Eulerian approach with tracking an explicit boundary ... Read More

Simulating Fluid Flow through a Culture Chip for Cell Migration Studies in Microgravity

A. Dhall [1], T. Masiello [1], L. Butt [1], M. Strohmayer [1], M. Hemachandra [1], N. Tokranova [1], J. Castracane [1],
[1] Colleges of Nanoscale Science and Engineering, SUNY Polytechnic Institute, Albany, NY, USA

Exposure to microgravity is known to alter genomic and proteomic expression and suppress immune cell activity. These changes may influence cancer development. Studying cancer cells in this environment, may help uncover novel therapeutic targets. SUNY Polytechnic Institute and ... Read More

Highly Sensitive Grating-Coupled Bloch Surface Wave Resonance Biosensor via Azimuthal Interrogation

V. Koju [1], W. M. Robertson [1],
[1] Middle Tennessee State University, Murfreesboro, TN, USA

A dielectric multilayer structure, with a grating profile on the surface layer, can couple light into a strongly confined surface wave, known as a Bloch surface wave. These surface modes can be used to design bio-sensors. The corrugated surface structure also enables azimuthal angular ... Read More

Numerical Simulation and Thermal Analysis of Tumor in the Human Body

S. Hossain [1], F. A. Mohammadi [1]
[1] Department of Electrical and Computer Engineering, Ryerson University, Toronto, ON, Canada

INTRODUCTION: Abnormalities in local body surface temperature have been recognized as a sign of disease for centuries, much before humans knew about the cause of ailments or of pain [1]. The idea of this work is to use numerical simulation tools to predict the location, size and ... Read More

Direct Numerical Simulation of Time Evolution of Vortex Ring

M. Hashiguchi [1],
[1] Keisoku Engineering System Co., Ltd., Chiyoda-ku, Tokyo, Japan

Vortex ring can be useful to generate thrust force for e.g., jellyfish, but its mechanism has not been clarified. In this field, it seems that numerical simulation has an important role of understanding the propulsion mechanism of creature. A vortex ring in a tube, refered to confined ... Read More

Development of a Single Cell Trapping Microfluidic Device

L. Weng [1], F. Ellett [1], J. F. Edd [1], M. Toner [1,2],
[1] Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
[2] Shriners Hospital for Children, Boston, MA, USA

Array-based technologies are important for many applications in drug discovery, microbiology and cell biology. A large-scale array of single cells allows high-throughput monitoring of behaviors of individual cells in parallel, avoiding the lack of cell specificity inherent to bulk ... Read More

Kinetics of Proteins in the Blood-Brain Barrier

K. Gandhi [1],
[1] University of California, Riverside, CA, USA

The delivery of chemotherapy for cancer into the central nervous system, in particular the brain, remains a challenge. This results in brain metastases commonly being a cause of death from cancer. Here, we look at the environment of the blood-brain barrier. Then, we explore two proteins ... Read More

Simulations of Microelectrode and Neuron Interfaces Enable Long-Term and High Fidelity Recordings

P. Wijdenes [1], H. Ali [2], N. Syed [3], C. Dalton [2],
[1] Centre for Bioengineering Research and Education, University of Calgary, Calgary, AB, Canada
[2] Department of Electrical and Computer Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada
[3] Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada

Our inability to record single cell activity with high resolution over a long period of time precludes fundamental understanding of nervous system functions, both under normal and pathological conditions. While the fabrication of current micro- and nano-electrodes has advanced our ... Read More

Simulation of Interstitial Nanoparticle Flow for Development of Tumor-On-A-Chip Device

J. Park [1], M. P. Vidal-Meza [1], R. Zhou [1], S. Barua [1], C. Wang [1],
[1] Missouri University of Science & Technology, Rolla, MO, USA

A simulation was performed to investigate the flow behaviors of drug delivery nanoparticles in a tumor-on-a-chip microfluidic device, which mimics a tumor cell having endothelial cells with micro-sized gaps. The Navier-Stokes equation and the convection-diffusion equation were used to ... Read More

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