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See How Multiphysics Simulation Is Used in Research and Development

Engineers, researchers, and scientists across industries use multiphysics simulation to research and develop innovative product designs and processes. Find inspiration in technical papers and presentations they have presented at the COMSOL Conference. Browse the selection below or use the Quick Search tool to find a specific presentation or filter by application area.

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Bioscience and Bioengineering

Comparing Isotropic and Anisotropic Brain Conductivity Modeling: Planning Optimal Depth-Electrode Placement in White Matter for Direct Stimulation Therapy in an Epileptic Circuit

L. C. Zaragoza[1], B. Hondorp[2], M. A. Rossi[3]
[1]ITESM, Monterrey, Mexico
[2]Rush Medical College, Chicago, IL, USA
[3]Rush University Medical Center, Chicago, IL, USA

The goal of our work was to calculate a patient-specific brain conductivity map for predicting the extent to which direct stimulation therapy can strategically propagate through pathological white matter. Our laboratory developed isotropic and anisotropic human brain finite element ... Read More

Extending Engineering Simulations to Scientists: Food Safety and Quality Prediction Using COMSOL Multiphysics® and LiveLink™ for Excel®

A. Warning[1], A. K. Datta[1]
[1]Cornell University, Ithaca, NY, USA

The objective of this study was to develop an easy to use interface in Excel® that connects to not only the solvers in COMSOL Multiphysics®, but also existing databases of food properties, foodborne pathogenic microorganisms kinetics, and chemical kinetics, creating a comprehensive ... Read More

Finite Element Analysis of Defibrillation Current Density in Pregnant Women

A. Jeremic[1], E. Khosrowshahli[1]
[1]McMaster University, Hamilton, ON, Canada

Although resuscitation during pregnancy is relatively uncommon and rarely causes death, they have a particularly large impact in terms of the mortality of the unborn child and long-term effects on families and society as whole. In this paper, we present a new 3D finite element model of a ... Read More

Generation of Lofted NURBS Curves for 3D Model Generation with COMSOL Multiphysics®

R.T. Hart[1]
[1]Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA

A key challenge to finding quantitative solutions to biological problems is to model the complex 3D geometry of naturally occurring structures. Model generation often starts from serial sections from CT or MRI scans, confocal microscopy, or physical sectioning. In addition, prior to V4 ... Read More

Development of a Multiphase, Multispecies Droplet Evaporation Model for Optimization of Desiccation Preservation Techniques

A. Sinkevich[1], S. Bhowmick [1], M. Raessi[1]
[1]University of Massachusetts Dartmouth, North Dartmouth, MA, USA

Biopreservation deals with the protection and storage of complex biologics such as proteins, lipids, and recently, mammalian cells. One preservation method, known as lyopreservation, involves placing a biologic inside a water droplet with some type of sugar excipient (sucrose, trehalose, ... Read More

Singlet Oxygen Modeling for PDT Incorporating Local Vascular Oxygen Diffusion

T. C. Zhu[1], B. Liu[1]
[1]University of Pennsylvania, Philadelphia, PA, USA

Singlet oxygen (1O2) is the major cytotoxic agent that kills cells during photodynamic therapy (PDT). Based on a previously-developed model, the distance-dependent reacted 1O2 can be numerically calculated using finite-element method. We improved the model to include microscopic kinetic ... Read More

Modeling Inertial Focusing in Straight and Curved Microfluidic Channels

J. Martel[1], N. Elabbasi[2], D. Quinn[2], J. Bergstrom[2], M. Toner[1]
[1]BioMEMS Resource Center, Massachusetts General Hospital, Boston, MA, USA
[2]Veryst Engineering, Needham, MA, USA

Inertial focusing is a promising microfluidic technique for separating and concentrating cells of interest, processes routinely utilized in many medical procedures. This phenomenon is characterized by suspended particles in a flow spontaneously migrating across streamlines to equilibrium ... Read More

Computational Modeling of the Electrohydrodynamics Influencing Trace Mercury Adsorption within Electric Utility Electrostatic Precipitators

H. Clack[1]
[1]University of Michigan, Ann Arbor, MI, USA

Anthropogenic mercury (Hg) emissions increase the risk of neurological and neonatal health effects in humans through fish consumption. There are several technological approaches to controlling mercury emissions from coal combustion, including the injection of a powdered mercury sorbent ... Read More

Coupled PDEs with Initial Solution from Data in COMSOL Multiphysics®

M. K. Gobbert[1], X. Huang[1], S. Khuvis[1], S. Askarian[1], B. E. Peercy[1]
[1]University of Maryland - Baltimore County, Baltimore, MD, USA

This paper presents information on techniques needed in COMSOL Multiphysics® to enable computational studies of coupled systems of PDEs for time-dependent non-linear problems. Furthermore, we demonstrate how to use data files as input for initial conditions. To illustrate the techniques, ... Read More

Modeling 3D Calcium Waves from Stochastic Calcium Sparks in a Sarcomere Using COMSOL Multiphysics®

L. T. Izu[1], Z. Coulibaly[2], B. Peercy[2]
[1]University of California-Davis, Davis, CA, USA
[2]University of Maryland, Catonsville, MD, USA

This paper utilizes the COMSOL Multiphysics® general form PDE interface and MATLAB® to model stochastic calcium waves in a sarcomere (basic unit of a heart cell). The model we present here shows the evolution of waves generated from calcium being released stochastically from sites ... Read More

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