M. Miliani, F. Piccagli
Medtronic Invatec S.p.A., Roncadelle, BS, Italy
During peripheral intravascular interventions one of the main issues is the correct deployment of the guidewire (GW) to the anatomical site which has to be treated, often supported by a microcatheter. There is a trade-off between the microcatheter flexibility and its push-ability to be able to reach the anatomical site. The catheter design has been defined with 2 transition zones. A parametric ...
R. Appali, S. Petersen, J. Gimsa, and U. Rienen
 Institute of General Electrical Engineering, Chair of Electromagnetic Field Theory, University of Rostock, Germany
 Institute of Biology, Chair of Biophysics, University of Rostock, Germany
Study of neurons plays a key role in the fields of basic and medical research aiming at the development of electrically active implants. The Fitzhugh-Nagumo equations are used to model and simulate the spike generation and propagation in a squid giant axon using COMSOL Multiphysics® 3.5a Software. It is shown that the Fitzhugh-Nagumo equations allow for a geometrical explanation of ...
Design and Simulation of a Microscale Magnetophoretic Device for the Separation of Nucleated Fetal Red Blood Cells from Maternal Blood
G. Schiavone, D.M. Kavanagh, and M.P.Y Desmulliez
Politecnico di Torino, Torino, Italy
MIcroSystems Engineering Centre, School of Engineering & Physical Sciences, Heriot-Watt University, Edinburgh, Scotland, United Kingdom
Intense research has been carried out into methods that aim at harvesting fetal cells from maternal blood as substitutes to amniocentesis and chorionic villus sampling. This work focuses on the separation of fetal nucleated red blood cells from the maternal circulation based on their intrinsic magnetic properties. The design and simulation of a magnetophoretic separator is described, as it will ...
L. T. Izu, Z. Coulibaly, B. Peercy
University of California-Davis, Davis, CA, USA
University of Maryland, Catonsville, MD, USA
This paper utilizes the COMSOL Multiphysics® general form PDE interface and MATLAB® to model stochastic calcium waves in a sarcomere (basic unit of a heart cell). The model we present here shows the evolution of waves generated from calcium being released stochastically from sites modeled as point sources. The release sites are distributed on z-disc (planes) in a hexagonal pattern, and their ...
E. Hollander, E. O. Kamenetskii, R. Shavit
Microwave Magnetic Laboratory, Department of Electrical and Computer Engineering, Ben Gurion University of the Negev, Beer Sheva, Israel
Microwave sensing and monitoring is very attractive for biological applications because of their sensitivity to water and dielectric contrast. Direct detection of biological structures in microwave frequencies and understanding of the molecular mechanisms of microwave effects is considered as a problem of a great importance. Nowadays, however, microwave technique for localized testing biological ...
S. Gerbino, and P. Franciosa
University of Molise, School of Engineering, Via Duca degli Abruzzi, Termoli, Italy
Understanding the stress-strain behavior of human foot tissues and pressure map distributions at the plantar interface is of interest into biomechanical investigations. In particular, monitoring plantar pressure maps is crucial to establishing the perceived human comfort of shoe insoles. A 3D anatomical detailed FE human foot model was created, starting from CT (Computer Tomography) scans of a ...
K. Basu, P. Ghosh, S. Bhattacharjee, S. Das , A. Chanda
School of Bio Science and Engineering, Jadavpur University, Kolkata, West Bengal, India
Department of Mechanical Engineering, Jadavpur University, Kolkata, West Bengal, India
Cardiovascular disease has become a major healthcare problem. To tackle this along with bypass surgery, the use of the cardiovascular stent is considered promising and effective. In this study, we aim to find the effectiveness of stent deployments and their influence on haemodynamics post their deployment in human arteries. For the study we have reconstructed single units of two commercially ...
P. Nakielski, T. Kowalczyk, T.A. Kowalewski
Institute of Fundamental Technological Research Polish Academy of Sciences, Warsaw, Poland
Comprehensive studies of drug transport in nanofibres based mats have been performed to predict drug release kinetics. The paper presents our approach to analyze the impact of fibers arrangement, one of the parameters varied in our parallel experimental studies. COMSOL Multiphysics® has been used to assess the impact of the various purposed arrangements of fibers within the mat. Drug release ...
H. T. D. Grigg, T. H. Hanley, B. J. Gallacher
Newcastle University, Newcastle, Tyne and Wear, UK
This work enunciates the principles of SAW design from a physical perspective, examining the standard engineering modelling assumptions in some detail. An integral form analytical expression based on 2D elastic isotropic theory is validated against a COMSOL Multiphysics® simulation, corresponding to the traditional COM approach. Next, a COMSOL model of the full 3D problem, including anisotropy, ...
Magnetic Heating of Iron Oxide Nanoparticles with Alternating Magnetic Field for Hyperthermia Applications
N. M. Sundaram, M. Sneha, R. S. Vishnu, M. Alagappan
PSG College of Technology Coimbatore, Tamil Nadu, India
The current therapies available to treat cancer patients are surgical operation and chemo therapy. The drawbacks are the side effects caused by these therapies. Hyperthermia is a treatment technique based on deactivation of cancer cells by raising the temperature in the range of 43 ºC and 48 ºC and has gained attention as an alternative therapy for cancer treatment. Iron oxide nanoparticles have ...