Technical Papers and Presentations

Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Electrohydrodynamic Micropump Modeling for Performance Optimization

A. Mulye[1], S. Potnis[2]
[1]Northeastern University, Boston, MA, USA
[2]VIT, Mumbai, Maharashtra, India

We present an optimized and efficient design of an electrohydrodynamic (EHD) micropump for high performance in microscale and biological applications. We are targeting two major applications, a parylene C design for electrically-actuated medicine delivery, and a silicon-based pump design for on-chip cooling of microprocessors and SOCs. The EHD micropump works on the movement of microscale ...

Simulation Organogenesis in COMSOL: Deforming and Interacting Domains

D. Iber[1], D. Menshykau[1]
[1]D-BSSE, ETH Zurich, Basel, Switzerland

Organogenesis is a tightly regulated process that has been studied experimentally for decades. We are developing mechanistic models for the morphogenesis of limbs, lungs, and kidneys with a view to integrate available knowledge and to better understand the underlying regulatory logic. Organ size changes dramatically during development, and tissues are composed of several layers that may expand ...

Computational Analysis on Commercially Available Stent Designs

K. Basu[1], P. Ghosh[2], S. Bhattacharjee[2], S. Das [2], A. Chanda[1]
[1]School of Bio Science and Engineering, Jadavpur University, Kolkata, West Bengal, India
[2]Department of Mechanical Engineering, Jadavpur University, Kolkata, West Bengal, India

Cardiovascular disease has become a major healthcare problem. To tackle this along with bypass surgery, the use of the cardiovascular stent is considered promising and effective. In this study, we aim to find the effectiveness of stent deployments and their influence on haemodynamics post their deployment in human arteries. For the study we have reconstructed single units of two commercially ...

Simulation of the Electrode-Tissue Interface with Biphasic Pulse Train for Epi-retinal Prosthesis

S. Biswas[1], S. Das[2], M. Mahadevappa[2]
[1]Advanced Technology Development Center, Indian Institute of Technology, Kharagpur
[2]School of Medical Science and Technology, Indian Institute of Technology, Kharagpur

Retinitis Pigmentosa (RP) and Age-related Macular Degeneration (AMD) are diseases causing blindness in a large number of people. In this type of degenerative disease, mostly the photoreceptors are damaged. Thus attempts have been made to electrically stimulate the surviving inner retinal neurons and retinal ganglion cells (RGC) in order to restore vision. In this paper, the electrode-tissue ...

Effects of Flow and Diffusion on Blood Coagulation in Platelet Poor Plasma: a Two-way Coupling Between Hemodynamics and Biochemistry

D. Magnabosco[1,2], H. van Ooijen[2], B. Bakker[2], R. van den Ham[2]
[1]Politecnico di Milano, Milan, Italy
[2]Philips Research, Eindhoven, The Netherlands

Enzyme reactions, blood flow and diffusion in human vasculature play interacting and fundamental roles in blood coagulation. In this complex mechanism, the balance between blood and clot is a delicate equilibrium, whose tight regulation is vital to avoid pathologies such as bleeding and thrombosis. The secondary hemostasis triggered by tissue factor in platelet poor plasma is studied up to fibrin ...

Some Commonly Neglected Issues Which Affect DEP Applications

G. Zhang[1], V. Pandian[1], J. Brcka[2], J. Faguet[2], E. Lee[2]
[1]Clemson University, Clemson, SC, USA
[2]TEL U.S. Holdings, Inc., U.S. Technology Development Center, Austin, TX, USA

Dielectrophoresis (or DEP) has been exploited for various micro and nano fluidics applications like patterning, sorting and separation. However, there are several commonly neglected issues in quantifying DEP forces. Such negligence could potentially lead to wrong DEP force predictions and estimates, posing difficulties in correlating experimental observations with theories. Among the commonly ...

Simulation of Transdermal Toxin Expulsion via Adsorptive Dermal Patch using COMSOL Multiphysics®

H. Kwon[1], M. Hess II[1], R. M. Polski
[1]Andrews University, Berrien Springs, MI, USA

Mathematical skin models play an important role in fields such as transdermal drug delivery and assessment of dermal exposure to industrial chemicals. Extensive research has been conducted on modeling skin for transdermal drug delivery; however, little effort has been made to view the skin as a permeable layer to expel waste chemicals or toxins from the body. In this work, we focused on topical ...

Singlet Oxygen Modeling for PDT Incorporating Local Vascular Oxygen Diffusion

T. C. Zhu[1], B. Liu[1]
[1]University of Pennsylvania, Philadelphia, PA, USA

Singlet oxygen (1O2) is the major cytotoxic agent that kills cells during photodynamic therapy (PDT). Based on a previously-developed model, the distance-dependent reacted 1O2 can be numerically calculated using finite-element method. We improved the model to include microscopic kinetic equations of oxygen diffusion from uniformly distributed blood vessels to the adjacent tissue. The blood vessel ...

Design of a Pressure Sensor to Monitor Teeth Grinding

I.M. Abdel-Motaleb[1], K. Ravanasa[1], K.J. Soderholm[2]
[1]Department of Electrical Engineering, Northern Illinois University, DeKalb, IL, USA
[2]Department of Restorative Dental Sciences, College of Dentistry, University of Florida, Gainesville, FL USA

Studying teeth grinding behavior and other oral conditions requires the ability to accurately measure the pressure on the teeth. Placing a sensor in the mouth requires small size devices with powering and measurement techniques that do not hinder the normal life of the patient. To meet these requirements, we designed, using COMSOL, a small, easy to read MEMS capacitive force sensor, with ...

Actively Controlled Ionic Current Gating In Nanopores

G. Zhang[1], S. Bearden[1]
[1]Clemson University, Clemson, SC, USA

It is necessary to understand and control nanopore behavior in order to develop biosensors for a variety of applications including DNA sequencing. The fluidics of nanopore devices we fabricated exhibits a range of interesting phenomena, such as enhanced conductance and current rectification. By electrically biasing nanopores, we were able to actively control the nanopore conductance in real time ...

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