Technical Papers and Presentations

Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

A Finite Element Model of Shear Wave Propagation Induced by an Acoustic Radiation Force Impulse

R. De Luca[1,2], J. Fromageau[1], H.W. Chan[1], F. Marinozzi[2], J. Bamber[1]
[1]Institute of Cancer Research and Royal Marsden Hospital, Sutton, England, United Kingdom
[2]Sapienza University of Rome, Dept. of Mechanical and Aerospace Engineering, Rome, Italy

Shear wave elastography is an innovative technique used in combination with the traditional ultrasound imaging to improve the specificity of cancer imaging. A two-dimensional finite element model (FEM), composed of realistic boundary conditions, was developed in COMSOL Multiphysics® to simulate the propagation of shear waves induced by an acoustic radiation force impulse (ARFI) in isotropic, ...

Finite Element Analysis of Defibrillation Current Density in Pregnant Women

A. Jeremic[1], E. Khosrowshahli[1]
[1]McMaster University, Hamilton, ON, Canada

Although resuscitation during pregnancy is relatively uncommon and rarely causes death, they have a particularly large impact in terms of the mortality of the unborn child and long-term effects on families and society as whole. In this paper, we present a new 3D finite element model of a pregnant female torso which accounts for presence of amniotic liquid and calculate current density ...

Actively Controlled Ionic Current Gating In Nanopores

G. Zhang[1], S. Bearden[1]
[1]Clemson University, Clemson, SC, USA

It is necessary to understand and control nanopore behavior in order to develop biosensors for a variety of applications including DNA sequencing. The fluidics of nanopore devices we fabricated exhibits a range of interesting phenomena, such as enhanced conductance and current rectification. By electrically biasing nanopores, we were able to actively control the nanopore conductance in real time ...

Simulating Organogenesis in COMSOL Multiphysics®: Parameter Optimization for PDE-based Models

D. Iber[1], D. Menshykau[2], P. Germann[2], L. Lermuzeaux[2,3]
[1]D-BSSE, ETH Zurich, Switzerland, SIB, Basel, Switzerland
[2]D-BSSE, ETH Zurich, Basel, Switzerland
[3]Department of Bioengineering, University of Nice-Sophia Antipolis, Nice, France

Morphogenesis is a tightly regulated process that has been studied for decades. Previously we developed data-based mechanistic models for a range of developmental processes with a view to integrate the available knowledge and to better understand the underlying regulatory logic. In our previous papers on simulating organogenesis in COMSOL Multiphysics® we discussed methods to efficiently solve ...

Understanding the Role of Nanomaterials in DNA Biosensors Through Finite Element Analysis

J. C. Kumaradas[1], A. Zhang[2], Y. D. Davletshin[1]
[1]Ryerson University, Toronto, ON, Canada
[2]University of Waterloo, Waterloo, ON, Canada

Tremendous progress is being made in the integration of nanoparticles into micro-analytical systems for biosensing. These materials are shown to enhance the analyte capture capability of biosensing platforms. We have implemented a computational model that considers the sensor’s geometry, size, analyte concentration and type to predict the number of nucleic acid molecules captured by ...

Simulation Organogenesis in COMSOL: Deforming and Interacting Domains

D. Iber[1], D. Menshykau[1]
[1]D-BSSE, ETH Zurich, Basel, Switzerland

Organogenesis is a tightly regulated process that has been studied experimentally for decades. We are developing mechanistic models for the morphogenesis of limbs, lungs, and kidneys with a view to integrate available knowledge and to better understand the underlying regulatory logic. Organ size changes dramatically during development, and tissues are composed of several layers that may expand ...

Simulation of the Electrode-Tissue Interface with Biphasic Pulse Train for Epi-retinal Prosthesis

S. Biswas[1], S. Das[2], M. Mahadevappa[2]
[1]Advanced Technology Development Center, Indian Institute of Technology, Kharagpur
[2]School of Medical Science and Technology, Indian Institute of Technology, Kharagpur

Retinitis Pigmentosa (RP) and Age-related Macular Degeneration (AMD) are diseases causing blindness in a large number of people. In this type of degenerative disease, mostly the photoreceptors are damaged. Thus attempts have been made to electrically stimulate the surviving inner retinal neurons and retinal ganglion cells (RGC) in order to restore vision. In this paper, the electrode-tissue ...

Modeling Light Propagation in Skin for Visualization of Subcutaneous Veins

H. Kwon[1], R. Huancaya[1]
[1]Andrews University, Berrien Springs, MI, USA

Vein visualization systems such as the VeinViewer are vein-contrast enhancement devices that use an infrared camera to highlight blood or the underlying vasculature and project the image in real time onto the skin. Understanding the light propagation in a realistic skin model is critical, but only a few computational models have been developed to account for this particular system. We have ...

Using COMSOL Multiphysics® for Biomechanical Analysis of Stent Technology in Cerebral Aneurysms

J. Rasmussen[1], M.S. Enevoldsen[1], J. Thyregod[2], and K-A. Henneberg[1]
[1]Department of Electrical Engineering, Technical University of Denmark, Kgs. Lyngby, Denmark
[2]COOK Medical Europe, Bjaeverskov, Denmark

This work presents new Fluid-Structure Interaction (FSI) models in both 2D and 3D of the effect of using vascular stents as treatment of cerebral berry aneurysms. The stent is positioned inside the cerebral artery covering the neck of the aneurysm. The stent is expected to alter the blood flow into the aneurysm such that the blood coagulates due to low blood velocity, and rupture of the aneurysm ...

Some Commonly Neglected Issues Which Affect DEP Applications

G. Zhang[1], V. Pandian[1], J. Brcka[2], J. Faguet[2], E. Lee[2]
[1]Clemson University, Clemson, SC, USA
[2]TEL U.S. Holdings, Inc., U.S. Technology Development Center, Austin, TX, USA

Dielectrophoresis (or DEP) has been exploited for various micro and nano fluidics applications like patterning, sorting and separation. However, there are several commonly neglected issues in quantifying DEP forces. Such negligence could potentially lead to wrong DEP force predictions and estimates, posing difficulties in correlating experimental observations with theories. Among the commonly ...

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