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See How Multiphysics Simulation Is Used in Research and Development

Engineers, researchers, and scientists across industries use multiphysics simulation to research and develop innovative product designs and processes. Find inspiration in technical papers and presentations they have presented at the COMSOL Conference. Browse the selection below or use the Quick Search tool to find a specific presentation or filter by application area.

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Bioscience and Bioengineering

Design of Dielectrophoretic Cell Traps in Microfluidics Devices Using COMSOL Multiphysics® Software

L. Velmanickam [1], K. Nawarathna [1],
[1] Department of Electrical and Computer Engineering, North Dakota State University, Fargo, ND, USA

The isolation of target cells from biological samples such as serum, urine or blood in high-throughput manner without contamination with other cells is the starting point of developing effective therapy for many diseases. Currently available methods for cell isolation/separation require ... Read More

Development of a Microfluidic-Based Electrochemical Cell for Analyzing Bacterial Biofilms

I. Claydon [1], J. Turner [1], B. Sammakia [1],
[1] Binghamton University, Binghamton, NY, USA

The ubiquitous nature of biofilms has led to a growing need to be able to detect, control, and maintain or remove them. Therefore a robust testing platform that allows for multiple analytical techniques is required to better understand their multitude of properties. The development of ... Read More

Development of an Oxygen-Conserving Mask for Pediatric Patients in Low-Resource Settings

D. Gasperino [1]
[1] Intellectual Ventures Laboratory, Bellevue, WA, USA

Worldwide, the leading cause of mortality in children is acute respiratory infection, primarily associated with pneumonia. One of the essential tools used to treat life-threatening hypoxemia due to pneumonia is the appropriate use of supplemental oxygen. While oxygen therapy is ... Read More

Influence of Non-Newtonian Blood Viscosity on Wall Pressure in Right Coronary Arteries with Serial Stenoses

B. Liu [1]
[1] Monmouth University, West Long Branch, NJ, USA

Three dimensional mathematical models are developed to simulate the blood flows in patient specific right coronary arteries with two stenoses. Simulations are carried out with various flow parameters under physiological conditions. Both Newtonian and non-Newtonian blood viscosity models ... Read More

Transdermal Drug Delivery with Permeation Enhancer

A. Kermani [1], N. Elabbasi [1]
[1] Veryst Engineering, Needham, MA, USA

Transdermal drug delivery (TDD) is used to deliver drugs through the skin as an alternative to oral, intravascular, and subcutaneous routes. While there are many advantages to TDD, skin is a very effective barrier and provides resistance to drug delivery. To improve drug delivery ... Read More

How Finite Element Analysis Revolutionized a 100-Year Old Equation

K. Carlson [1], J. Arle [1], J. L. Shils [2], L. Mei [1],
[1] Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA
[2] Rush Medical Center, Chicago, IL, USA

In 1901 Weiss proposed an equation predicting activation of nerve fibers by electrical stimulation, used in neuroscience and neuromodulation, which applies electric fields to modify nerve behavior in neurological disorders. Weiss’ equation is relative to geometry, electrode array, ... Read More

Advanced Modeling of a Lung-on-a-Chip Microdevice

M. J. Hancock [1], N. H. Elabbasi [1],
[1] Veryst Engineering, Needham, MA, USA

Organ-on-a-chip microdevices combine microfluidics, MEMS, and biotechnology techniques to mimic the multicellular architectures, tissue-tissue interfaces, physicochemical microenvironments, and vascular perfusion of the body.[1] Such devices are being developed to provide better levels ... Read More

Nonlinear Mechanical Modeling of Thermoplastics

J. Bergstrom [1], N. Elabbasi [1],
[1] Veryst Engineering, Needham, MA, USA

The use of thermoplastic materials is increasing and it is becoming more important during the design process to accurately represent the non-linear material response in relevant loading conditions. The COMSOL Multiphysics® software supports advanced modeling capabilities for large ... Read More

Theoretical and Experimental Validation of Micro Hot Embossing on Polymeric Substrates

F. Lai [1], N. K. Shivaprakash [1], J. Zhang [1], A. Panwar [1], J. Mead [1], C. Barry [1], Q. Truong [2],
[1] University of Massachusetts Lowell, Lowell, MA, USA
[2] US Army Natick Soldier Research, Development and Engineering Center, Natick, MA, USA

Micro hot embossing on a large area polymeric substrates using roll-to-roll (R2R) mode has been considered as one of the most promising technologies that can offer continuous fabrication of large area polymeric substrates. Besides continuous operation, roll-to-roll (R2R) process offers ... Read More

FEM Analysis and Optimization of Electro-Stimulating Implants for Bone Regeneration and Prevention of Bacterial Infection

T. Bender [1], J. Ziebart [2], T. J. Dauben [1], B. Kreikemeyer [3], R. Bader [2]
[1] Institute of Medical Microbiology, Virology and Hygiene, Rostock University Medical Center, Rostock, Germany; Research Laboratory for Biomechanics and Implant Technology, Department of Orthopedics, Rostock University Medical Center, Rostock, Germany
[2] Research Laboratory for Biomechanics and Implant Technology, Department of Orthopedics, Rostock University Medical Center, Rostock, Germany
[3] Institute of Medical Microbiology, Virology and Hygiene, Rostock University Medical Center, Rostock, Germany

The aim of this study is to investigate the influence of electro-magnetic stimulation on bone regeneration and the effect on bacterial infection. Electro-magnetic stimulation is a promising technique and a powerful tool for the enhancement of bone regeneration. To optimize the amplitude ... Read More

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