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See How Multiphysics Simulation Is Used in Research and Development

Engineers, researchers, and scientists across industries use multiphysics simulation to research and develop innovative product designs and processes. Find inspiration in technical papers and presentations they have presented at the COMSOL Conference. Browse the selection below or use the Quick Search tool to find a specific presentation or filter by application area.

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Bioscience and Bioengineering

Feed-forward/Feed-backward Mechanical Amplification in the Mouse Cochlea

J. Soons[1,2], C. Steele[2], S. Puria[2]
[1]Lab of Biomedical physics, University of Antwerp, Antwerp, Belgium
[2]Department of Mechanical Engineering, Stanford University, Stanford, USA

Sound vibrations are collected from the external environment by the eardrum and are guided to the basilar membrane in the cochlea. Pressure differences in the two scalae of the cochlea result in a traveling wave on the basilar membrane. The tiny displacements are detected by the ... Read More

Effects of Flow and Diffusion on Blood Coagulation in Platelet Poor Plasma: a Two-way Coupling Between Hemodynamics and Biochemistry

D. Magnabosco[1,2], H. van Ooijen[2], B. Bakker[2], R. van den Ham[2]
[1]Politecnico di Milano, Milan, Italy
[2]Philips Research, Eindhoven, The Netherlands

Enzyme reactions, blood flow and diffusion in human vasculature play interacting and fundamental roles in blood coagulation. In this complex mechanism, the balance between blood and clot is a delicate equilibrium, whose tight regulation is vital to avoid pathologies such as bleeding and ... Read More

Simulating Thermotherapeutic Response Induced by Thermal Padding for Treating Acute Injuries

J. Kantor[1], Y. Feng[1], C. Acosta[1], E. Massingill[1]
[1]University of Texas at San Antonio, San Antonio, TX, USA

Cryotherapy and thermotherapy are common methods of treatment for acute injuries ranging from ankle sprains to complex surgery. The idea behind such treatment is that a change in temperature will reduce pain and constrict fluctuations in blood flow at the targeted area. The purpose of ... Read More

In Silico Evaluation of Local Hemodynamics Following Vena Cava Filter Deployment

J. Ferdous[1], M. Ghaly [2], V. B. Kolachalama [3], T. Shazly[1,4]
[1]Biomedical Engineering Program, University of South Carolina, Columbia, SC, USA
[2]Department of Biomedical Engineering, North Carolina State University, Raleigh, NC, USA
[3]Charles Stark Draper Laboratory, Cambridge, MA, USA
[4]Department of Mechanical Engineering, University of South Carolina, Columbia, SC, USA

Inferior vena cava (IVC) filters have become essential components in deep vein thrombosis treatment to prevent preventing pulmonary embolisms. Filter efficacy relies on maintaining IVC patency by preventing filter-induced thrombosis following clot capture. A computational model has been ... Read More

Evaluation of Performance of Enzymatic Biofuel Cells with Microelectrode Arrays Inside a Blood Artery via Finite Element Approach

C. Wang[1], Y. Song[1]
[1]Florida International University, Miami, FL, USA

Enzymatic biofuel cells (EBFCs) are considered as a promising candidate for powering miniature implantable devices. In order to predict the performance in the human blood artery, we simulated a 3D EBFC chip with highly dense micro-electrode arrays. In this simulation using COMSOL ... Read More

Determination of Mechanic Resistance of Osseous Element Through Finite Element Modeling

E. Isaza[1], E. Salazar[1], L. Florez[1]
[1]Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia

The consequences of hip fracture and femoral fracture are widely known. The mechanical strength of the femur varies in every person, but it is possible to predict the mechanical resistance with parameters like density, dimensions and mineral content. This paper uses different models and ... Read More

Electrical Response and Thermal Damage Assessment of Cutaneous and Subcutaneous Tissues to Noninvasive Radiofrequency Heating: A Computational Modeling Study

A. González-Suárez[1,2], J. N. Jimenez-Lozano[3], W. Franco[1]
[1]Wellman Center for Photomedicine, Massachusetts General Hospital & Harvard Medical School, Boston, MA, USA
[2]Biomedical Synergy, Electronic Engineering Department, Universitat Politècnica de València, Valencia, Spain
[3]ZELTIQ Aesthetics, Inc., Pleasanton, CA, USA

Electromagnetic radiofrequency (RF) sources are widely used to heat up cutaneous and subcutaneous tissues. The subcutaneous morphology of tissue consists of a fine, collagenous and fibrous septa network enveloping clusters of adipocyte cells; however, it is commonly regarded as a ... Read More

Flow-induced Vibrations of the Uvula and its Implication on Snoring

J. Xi[1], Q. M. Mohamad[1], Y. E. Yuan[1], J. Rohlinger[1]
[1]Mechanical and Biomedical Engineering, Central Michigan University, Mount Pleasant, MI, USA

Flow-induced uvula deformation considerably altered the flow dynamics inside the nose. For a weak soft palate, complete flow occlusion can occur (sleep apnea). Vibration of the airway structures is crucial to better understand snoring generation mechanisms and breathing-related ... Read More

A Multiphase Porous Medium Transport Model with Distributed Sublimation Front to Simulate Vacuum Freeze Drying

A. Warning[1], J. M. R. Arquiza[1], A. K. Datta[1]
[1]Cornell University, Ithaca, NY, USA

A continuum, porous medium formulation with non-equilibrium sublimation was developed and validated for freeze drying without and with uniform microwave volumetric heating. The model incorporates the effect of Knudsen flow at low pressure and low permeability freeze drying. The ... Read More

Understanding the Role of Nanomaterials in DNA Biosensors Through Finite Element Analysis

J. C. Kumaradas[1], A. Zhang[2], Y. D. Davletshin[1]
[1]Ryerson University, Toronto, ON, Canada
[2]University of Waterloo, Waterloo, ON, Canada

Tremendous progress is being made in the integration of nanoparticles into micro-analytical systems for biosensing. These materials are shown to enhance the analyte capture capability of biosensing platforms. We have implemented a computational model that considers the sensor’s geometry, ... Read More

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