Technical Papers and Presentations

Cell morphology, orientation, and fate of differentiated stem cells can be affected by mechanical stimulation. Mechanobiological studies help to understand the molecular mechanisms of cells sensing and responding to mechanical cues. Previously, we have developed a vacuum-operated ... Read More

Background and novelty Organ-on-a-chip-systems represent a powerful alternative to substance testing in animal trials. The basic idea behind this approach is to emulate the smallest physiological unit of an organ on a chip. For this purpose, micro-environments must be created, that ... Read More

Brain-Machine Interfaces (BMI) provide a direct communication link between brain and external devices such as speech synthesizers and robotic prosthesis to restore speech and movement in persons affected by Spinal Cord Injuries or neurodegenerative diseases such as Amyotrophic Lateral ... Read More

We present here the development of an optical human eye model – based on Ray Optics module in order to reproduce the eye optical properties. Current simulations in literature do not fully cover the light propagation inside all parts of the eye by taking into account the absorption but ... Read More

Alternating 200 kHz electric fields ~2 V/cm (Tumor Treating Fields, ‘TTFields’) kill cancer cells by disrupting the delicate orchestration of chromosome spindle formation, but the exact mechanism of action is unknown. The likely suspects are polarized intracellular molecules such as ... Read More

Microneedles have been recognized as a potent and novel method of transdermal drug delivery over the last decade. Despite recent advances in nano- and microfabrication techniques, less is known about the structural properties and design optimization of microneedles in a systematic ... Read More

Neurological disorders afflict tens of millions in the US. We are developing technology to advance capabilities for monitoring the neurotransmitters, dopamine, norepinephrine, and epinephrine (the catecholamines), to facilitate direct observations of their mutual interactions in brain ... Read More

Dermal wounds have a high occurrence, and wounds that require surgical closure have been shown to result in up to 11 million keloid scars that might result from abnormal healing of these wounds. While small and superficial wounds generally heal effectively without treatment, large, deep, ... Read More

In the decades since humans first went to space, there has been growing interest in utilizing microgravity to improve our understanding in many scientific fields (1). Applied fields have included evolutionary development, cell mechanics and protein crystallization (2-4). Microgravity ... Read More

Approximately 450,000 people worldwide suffering from hearing problems use cochlear implants (http://www.cochlear.com/au/home/connect/cochlear-hearing-ambassador, June 12, 2018). Manual insertion of the cochlear implant during surgery can potentially damage the delicate tissues within ... Read More