Degradation of DNA in Plasma

Application ID: 1391

Biotechnology is a rapidly growing area in the pharmaceutical sciences. One example of a clinical application is gene therapy, where it is possible to produce proteins in vivo, using the body’s own mechanisms for protein production. Major issues in gene delivery involve the transport of plasmid DNA (pDNA) to target sites and the conversion between different forms of pDNA.

This example illustrates the use of the Parameter Estimation feature of the Reaction Engineering interface to find the rate constants of the three consecutive reactions involved in a typical DNA degradation process.

This model example illustrates applications of this type that would nominally be built using the following products: