Degradation of DNA in Plasma
Application ID: 1391
Biotechnology is a rapidly growing area in the pharmaceutical sciences. One example of a clinical application is gene therapy, where it is possible to produce proteins in vivo, using the body’s own mechanisms for protein production. Major issues in gene delivery involve the transport of plasmid DNA (pDNA) to target sites and the conversion between different forms of pDNA.
This example illustrates the use of the Parameter Estimation feature of the Reaction Engineering interface to find the rate constants of the three consecutive reactions involved in a typical DNA degradation process.
This model is included as an example in the following products:Chemical Reaction Engineering Module
however additional products may be needed to reproduce it. This example may be created and run using components from the following product combinations:
The combination of COMSOL® products required to model your application depends on several factors and may include boundary conditions, material properties, physics interfaces, and part libraries. Particular functionality may be common to several products. To determine the right combination of products for your modeling needs, review the Specification Chart and make use of a free evaluation license. The COMSOL Sales and Support teams are available for answering any questions you may have regarding this.