Drug Release from a Biomaterial Matrix

Application ID: 786

In this example, drug-release from a biomaterial matrix to damaged cell tissue is modeled. Specifically, a nerve guide delivers a regenerating drug to damaged nerve ends. The model involves detailed drug release kinetics, with rate expressions handling drug dissociation/association reactions as well as matrix degradation by enzyme catalysis. The enzyme reaction is described by Michaelis-Menten kinetics.

The detailed reaction and transport description used in this model allows for investigation of many design parameters relevant to the bioengineering. For instance, the effect of matrix degradation on drug release is presented as a function of time and geometry.

This model example illustrates applications of this type that would nominally be built using the following products: