3D-Simulation of Action Potential Propagation in a Squid Giant Axon

R. Appali[1], S. Petersen[1], J. Gimsa[2], and U. Rienen[1]
[1] Institute of General Electrical Engineering, Chair of Electromagnetic Field Theory, University of Rostock, Germany
[2] Institute of Biology, Chair of Biophysics, University of Rostock, Germany
Published in 2009

Study of neurons plays a key role in the fields of basic and medical research aiming at the development of electrically active implants. The Fitzhugh-Nagumo equations are used to model and simulate the spike generation and propagation in a squid giant axon using COMSOL Multiphysics® 3.5a Software. It is shown that the Fitzhugh-Nagumo equations allow for a geometrical explanation of important biological phenomena related to neuronal excitability and spike-generating mechanisms