COMSOL Multiphysics Simulations of Microfluidic Systems for Biomedical Applications

M. Dimaki, J. Moresco Lange, P. Vazquez, P. Shah, F. Okkels, and W. Svendsen
Department of Micro- and Nanotechnology, Technical University of Denmark, Lyngby, Denmark

The need for fast, easy and cost-effective analysis of blood samples as well as our understanding of the functionality of cells and neurons are two rather pressing issues in the modern world. Both of these can be addressed by functional lab-on-a-chip systems, which have been designed and optimized for specific analyses.

This paper deals with the design of several different systems for cell growth, cell sorting and cell lysing, as well as systems for the manipulation of human chromosomes by electrical forces (dielectrophoresis and electrophoresis).

We have used COMSOL Multiphysics in order to simulate fluid flow and electrical fields inside various structures and used the results to optimize their design.