Kinetics of Proteins in the Blood-Brain Barrier

K. Gandhi [1],
[1] University of California, Riverside, CA, USA
Published in 2016

The delivery of chemotherapy for cancer into the central nervous system, in particular the brain, remains a challenge. This results in brain metastases commonly being a cause of death from cancer. Here, we look at the environment of the blood-brain barrier. Then, we explore two proteins (breast cancer resistance protein and p-glycoprotein) that may inhibit the transport of medications (erlotinib and flavopiridol) across the blood-brain barrier. Next, we look at a mathematical model to quantify the effect of these two efflux-inducing proteins on transport. Last, I create a model using the COMSOL Multiphysics® software to describe and predict behavior at the blood-brain barrier (BBB) with respect to one of the chemotherapeutic agents (erlotinib).