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Modeling Drug Release from Materials Based on Electrospun Nanofibers

P. Nakielski[1], T. Kowalczyk[1], T.A. Kowalewski[1]
[1]Institute of Fundamental Technological Research Polish Academy of Sciences, Warsaw, Poland

Comprehensive studies of drug transport in nanofibres based mats have been performed to predict drug release kinetics. The paper presents our approach to analyze the impact of fibers arrangement, one of the parameters varied in our parallel experimental studies. COMSOL Multiphysics® has been used to assess the impact of the various purposed arrangements of fibers within the mat. Drug release from nanofibers was modeled by adsorption - desorption and diffusion equation. Our study shows that for the same material porosity drug release from the matrix of regularly oriented fibers is slower than from randomly oriented, isotropic nanofibrous material. Also by decreasing distance between the fibers drug transport rate is reduced.