Multiscale Electromagnetic Modeling of Contractions in the Pregnant Uterus
Uterine contractions during pregnancy are currently poorly understood – experts disagree on the mechanisms by which contractions propagate through the organ and the structural layout of the uterine muscle fibers. We have developed a multi-scale model of the uterus, at the cellular, tissue, and organ levels. By comparing simulated abdomen-level magnetic field readings from our model to clinical measurements, we hope to create a framework by which propagation mechanisms and fiber structures can be compared and validated. This in turn will facilitate interpretation of the real-world measurements, allowing the state of the transmembrane potential in the uterus to be estimated from the state of the magnetic field at the abdomen surface.