Simulation Organogenesis in COMSOL: Deforming and Interacting Domains

D. Iber[1], D. Menshykau[1]
[1]D-BSSE, ETH Zurich, Basel, Switzerland

Organogenesis is a tightly regulated process that has been studied experimentally for decades. We are developing mechanistic models for the morphogenesis of limbs, lungs, and kidneys with a view to integrate available knowledge and to better understand the underlying regulatory logic. Organ size changes dramatically during development, and tissues are composed of several layers that may expand both together or independently. Here we discuss methods to build and efficiently solve models in COMSOL, that are defined on a composite domain comprising several sub-domains, that involve implicitly defined deformations of simple and composite domains, that involve explicitly defined deformations of composite domains. We implement our models in COMSOL combining PDE and Moving Mesh interfaces.