See How Multiphysics Simulation Is Used in Research and Development
Engineers, researchers, and scientists across industries use multiphysics simulation to research and develop innovative product designs and processes. Find inspiration in technical papers and presentations they have presented at the COMSOL Conference. Browse the selection below or use the Quick Search tool to find a specific presentation or filter by application area.
View the COMSOL Conference 2023 Collection
Simulating Small Molecule Transport Across the Blood-Brain Barrier Using COMSOL Multiphysics®
The blood-brain barrier presents a unique and highly selective semipermeable barrier composed of endothelial and supporting cells. In stressed states, such as during systemic inflammation, the barrier can become “leaky”, increasing in permeability and leading to unwanted solutes from the ... Read More
Modeling Thrombosis through Viscosity Variation in a Coupled CFD-Chemical Kinetics Simulation
Thrombosis is the formation of a thrombus or blood clot within a vessel to maintain the integrity of the circulatory system [1]. The process involves surface interactions, with coagulation leading to the formation of thrombin and a fibrin network, and platelet aggregation [2]. ... Read More
Key Lessons from Multi-Scale Modeling of Body, Tissue, Cell, and Sub-Cellular Structures
Modeling the effects of electromagnetic fields on biological structures on the order of the body and tissues to the micro (1e-6)-and nano (1e-9) level of cells and sub-cellular structures presents formidable challenges. We share the major lessons we have learned using COMSOL ... Read More
3D Analyses of Changes in Free Bubble-Induced Stresses on Blood Vessel Wall in Ultrasound Therapy
Microbubble oscillations in the presence of ultrasound wave inside blood vessel have been widely studied for therapeutic applications like drug and gene delivery[1], blood-brain barrier opening[2], and lysis of blood clot[3] and cell membrane[4]. An oscillating bubble exerts stresses on ... Read More
Simulation of Oxygen Transport and Cellular Uptake in a Microphysiological System
Microphysiological systems (MPS) combine microfluidics, MEMS, and biotechnology techniques to mimic human organ function in vitro. Such devices are being developed to provide better levels of tissue and organ functionality compared with conventional cell culture systems, and have great ... Read More
Stress Analysis on a Capsule Robot Due to the Peristaltic Movement of the Intestine
A significant population of microorganisms (bacteria, archae and fungi) live inside the gastrointestinal (GI) tract, and are collectively known as microbiota [1]. The microbiota contain lifelong information on the health of an individual and can assist in early diagnosis of diseases such ... Read More
Fluid-Structure Interaction Studies of Coronary Artery Disease Biomechanics
Cardiovascular diseases are the leading cause of death worldwide. In the United States, coronary artery disease accounts for 1 in 7 cardiovascular deaths. Cells in the blood and blood vessels are known to respond to alterations of the mechanical forces of their environment, such as blood ... Read More
Modeling of 3D Cilium Mechanics in COMSOL® Using Beam Physics with Linear Extrusion Coupling
Cilia are slender micro-organelles (200 nm diameter, 10 µm long) that generate propagating waves to propel cells or move fluid. The cytoskeletal structure of the cilium (the axoneme) consists of 9 outer microtubule doublets and 2 central microtubule singlets. Outer doublets are connected ... Read More
Simulation of Basal Body Deformation in Tetrahymena Thermophila
COMSOL® models of basal body deformation using the Beam Interface are compared to electron tomograms of Tetrahymena thermophila basal bodies high-pressure frozen while undergoing beating deformation. This approach provides insight into the nanoscale structures and internal forces ... Read More
Precision and Bias in Field Methods for Measuring Soil Saturated Hydraulic Conductivity
The Subsurface Flow Module within COMSOL Multiphysics® was utilized to simulate variable saturated subsurface flow for multiple field methods that estimate the saturated hydraulic conductivity (Ksat) of the soil. The subsurface flow module implemented the Richards equation with a user ... Read More