Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Comparing Isotropic and Anisotropic Brain Conductivity Modeling: Planning Optimal Depth-Electrode Placement in White Matter for Direct Stimulation Therapy in an Epileptic Circuit

L. C. Zaragoza[1], B. Hondorp[2], M. A. Rossi[3]
[1]ITESM, Monterrey, Mexico
[2]Rush Medical College, Chicago, IL, USA
[3]Rush University Medical Center, Chicago, IL, USA

The goal of our work was to calculate a patient-specific brain conductivity map for predicting the extent to which direct stimulation therapy can strategically propagate through pathological white matter. Our laboratory developed isotropic and anisotropic human brain finite element method (FEM) models derived from SPGR magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI), ...

Heat Transfer and Phase Transformation on Matrix Assisted Pulsed Laser Evaporation (MAPLE) of Biocompatible Thin Layers

E. Lacatus[1], G.C. Alecu[1], M.A. Sopronyi[2], A. Tudor[1]
[1]POLITEHNICA University of Bucharest, Bucharest, Romania
[2]INFLPR -National Institute for Laser Plasma and Radiation Physics, Bucharest, Romania

Matrix Assisted Pulsed Laser Evaporation (MAPLE) technique is used for the deposition of high quality biocompatible polymer thin films. During the deposition process the temperature of the laser target should be kept below 193K to assure the proper quality of both evaporation and deposition phases of the process. On a first approach COMSOL Multiphysics® was used to describe and analyze the ...

Simulating Organogenesis with COMSOL Multiphysics® software: Phase-Field Based Simulations of Embryonic Lung Branching Morphogenesis

L. D. Wittwer [1], R. Croce [1], D. Iber [1],
[1] ETH Zürich, Zurich, Switzerland

While many biological details in organogenesis have been uncovered, fundamental questions regarding the control of growth and shape during lung and kidney morphogenesis remain unsolved. Using mathematical models, we recently showed that only ligand-receptor based Turing models successfully reproduce the experimentally determined growth fields of the embryonic lung and thus provide a mechanism ...

Simulation of the Electrode-Tissue Interface with Biphasic Pulse Train for Epi-retinal Prosthesis

S. Biswas[1], S. Das[2], M. Mahadevappa[2]
[1]Advanced Technology Development Center, Indian Institute of Technology, Kharagpur
[2]School of Medical Science and Technology, Indian Institute of Technology, Kharagpur

Retinitis Pigmentosa (RP) and Age-related Macular Degeneration (AMD) are diseases causing blindness in a large number of people. In this type of degenerative disease, mostly the photoreceptors are damaged. Thus attempts have been made to electrically stimulate the surviving inner retinal neurons and retinal ganglion cells (RGC) in order to restore vision. In this paper, the electrode-tissue ...

Simulation and Experimental Characterizations of a Thin Touch Mode Capacitive Pressure Sensor

A.-M. El Guamra [1], D. Bühlmann [1], F. Moreillon [1], L. Vansteenkiste [1], P. Büchler [2], A. Stahel [3], P. Passeraub [1],
[1] HES-SO University of Applied Sciences Western Switzerland, Delémont, Switzerland
[2] Institute for Surgical Technology & Biomechanics, University of Bern, Bern, Switzerland
[3] Bern University of Applied Sciences Engineering and Information Technology, Bern, Switzerland

Introduction: This study describes a thin and low-cost capacitive pressure sensor in touch mode (TM) for monitoring fluid pressure from 0 to 40kPa in fluidic chambers with Luer fittings for medical applications. TM provides good linearity, large measuring range and large overload protection [1]. The choice of a thin polymer membrane as sensitive element with printed circular electrodes reduces ...

Modeling and Simulation of Drug Release through Polymer Matrices - new

V. Runkana[1], A. Pareek[1], P. Arora[2]
[1]Tata Consultancy Services, Pune, Maharashtra, India
[2]Indian Institute of Technology Delhi, New Delhi, Delhi, India

Limited drug efficacy, undesirable temporal changes in drug concentration and patient non-compliance due to frequent dosing schedule have given impetus to design of controlled drug release systems [1]. Biodegradable polymers due to their favorable and tunable properties and biocompatibility have found widespread use in the field of controlled drug delivery [2]. Exploratory in vitro experiments ...

CMUT Based Free Membrane Intra-Cardiac Volumetric Blood Flow-Meter

P. Priya [1], B. D. Pant [2],
[1] Birla Institute of Technology and Science Pilani, Pilani, Rajasthan, India
[2] CSIR-Central Electronics Engineering Research Institute, Pilani, Rajasthan, India

In this paper, a free membrane is used as a receiver to increase the capacitance and therefore the resolution of the flow meter. For the current application, from the wavelength of sound wave in soft tissue (c= 1540 m/s) the resolution was calculated to be 0.48 mm. This gives the first Eigen frequency of the capacitive structure according to which the poly silicon membrane was designed. After ...

Pushability Model of a Microcatheter for Intravascular Procedures

M. Miliani[1], F. Piccagli[1]
[1]Medtronic Invatec S.p.A., Roncadelle, BS, Italy

During peripheral intravascular interventions one of the main issues is the correct deployment of the guidewire (GW) to the anatomical site which has to be treated, often supported by a microcatheter. There is a trade-off between the microcatheter flexibility and its push-ability to be able to reach the anatomical site. The catheter design has been defined with 2 transition zones. A parametric ...

From Music to Non-Invasive Therapies via COMSOL Multiphysics® Models - new

E. Lacatus[1], G. C. Alecu[2], A. Tudor[2], M. A. Sopronyi[3]
[1]Polytechnic University of Bucharest, Bucharest, Romania
[2]Student-Polytechnic University of Bucharest, Bucharest, Romania
[3]INFLPR -National Institute for Laser Plasma and Radiation Physics, Bucharest, Romania

Vibration and music therapies are non-invasive treatments having effective results although their basics are still disputed. By the application of COMSOL Multiphysics® software for modeling and analysis, some of the nonlinear physical phenomena laying on these applications may be clarified. Acoustic environmental stimuli at different intensities are continuously interacting with our bodies, ...

Simulating Organogenesis in COMSOL Multiphysics®: Image-Based Modeling - new

D. Iber[1,3], Z. Karimaddini[1,3], E. Unal[1,2], D. Menshykau[1,3]
[1]D-BSSE, ETH Zurich, Basel, Switzerland
[2]DBM University of Basel, Basel, Switzerland
[3]Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland

Mathematical Modeling has a long history in developmental biology. Advances in experimental techniques and computational algorithms now permit the development of increasingly more realistic models of organogenesis. In particular, 3D geometries of developing organs have recently become available. In this paper, we show how to use image-based data for simulations of organogenesis in the COMSOL ...