Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Actively Controlled Ionic Current Gating In Nanopores

G. Zhang[1], S. Bearden[1]
[1]Clemson University, Clemson, SC, USA

It is necessary to understand and control nanopore behavior in order to develop biosensors for a variety of applications including DNA sequencing. The fluidics of nanopore devices we fabricated exhibits a range of interesting phenomena, such as enhanced conductance and current rectification. By electrically biasing nanopores, we were able to actively control the nanopore conductance in real time ...

Simulation and Experimental Analysis of Drug Release Rates from Magnetic Nanocomposite Spheres - new

L. Saeeednia[1], H. Mehraein[2], F. Abedin[1], K. Cluff[2], R. Asmatulu[1]
[1]Department of Mechanical Engineering, Wichita State University, Wichita, KS, USA
[2]Department of Bioengineering, Wichita State University, Wichita, KS, USA

Targeted drug delivery systems have been wildly studied in cancer therapy due to the toxicity of most of chemotherapeutic drugs. Nanoparticles can be attached to the small molecules of the drugs and serve as drug carriers to deliver the drug molecules into the area of interest. In this research, polymeric microspheres containing biodegradable poly(D, L-lactide-co-glycolide) (PLGA), magnetic ...

Simulation of a Magnetic Induction Method for Determining Passive Electrical Property Changes of Human Trunk Due to Vital Activities

H. Mahdavi[1], J. Rosell Ferrer[1]
[1]Universitat Politècnica de Catalunya, Barcelona, Spain

The human body consists of many different types of tissues each with specific passive electrical properties. Vital activities lead to a characteristic change of these properties and geometrical changes. Magnetic induction is a non-contact method which can be used to determine these changes. The method is based on the creation of a primary magnetic field that will produce eddy currents in the ...

Transport and Concentration of Charged Molecules in a Lipid Membrane - new

S. D. Evans[1], J. S. Roth[1], M. R. Cheetham[1]
[1]University of Leeds, Leeds, UK

Brownian ratchets and electric fields are used for the transport of membrane components. Transport is achieved through the combination of a pattern with free diffusion. We show a good agreement between simulation and experiment, therefore allowing for further optimisation of the ratchets using COMSOL Multiphysics. In addition to the transport device we also introduce the possibility to ...

Computational Study on Transcutaneous Frontal Nerve Stimulation: Simplification of Human Head Model

E. Salkim [1], A. N. Shiraz [1], A. Demosthenous [1],
[1] Electronic and Electrical Department, University College London, London, UK

I. INTRODUCTION Migraine is a neurological disorder which affects nearly 15% of the population and it has been estimated that the European Community spends about €27 billion in a year. Its symptoms may be categorized as attacks of often severe, throbbing head pain with sensory sensitivity of light and sound. It is mainly related to trigeminal nerve, the supraorbital nerve (SON) and ...

3-D Finite Element Modeling of Brain Edema: Initial Studies on Intracranial Pressure Using COMSOL Multiphysics®

X.G. Li[1], H. von Holst[1][2], J. Ho[1], and S. Kleiven[1]

[1]Division of Neuronic Engineering, KTH, Stockholm, Sweden
[2]Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden

Brain edema is one of the most common consequences of serious traumatic brain injuries which is usually accompanied with increased Intracranial Pressure (ICP) due to water content increment. A three dimensional finite element model of brain edema is used to study intracranial pressure in this paper. Three different boundary conditions at the end of Cerebral Spinal Fluid (CSF) were used to ...

On A Particle Tracking Technique To Predict Disinfection In Drinking Water Treatment Systems

B.A. Wols[1,2], J.A.M.H. Hofman[1,2], W.S.J. Uijttewaal[2], and J.C. van Dijk[2]
[1]KWR Watercycle Research Institute, Nieuwegein, The Netherlands
[2]Delft University of Technology, Niewegein, The Netherlands

Disinfection of drinking water is required to prevent the outbreak of water-borne diseases. Different treatment steps are available to disinfect the water, such as chlorination, ozonation or UV irradiation. The hydrodynamics of these processes play an important role in their performance. COMSOL Multiphysics was used to simulate the water flow in disinfection installations. Moreover, a particle ...

Numerical Homogenization in Multi-scale Models of Musculoskeletal Mineralized Tissues

A. Gerisch[1], S. Tiburtius[1], Q. Grimal[2], and K. Raum[3]
[1]Technische Universität Darmstadt, Darmstadt, Germany
[2]Laboratoire d’Imagerie Paramétrique, UPMC, Paris, France
[3]Julius Wolff Institut & Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany

Musculoskeletal mineralized tissues (MMTs), e.g. bone, are hierarchical composite materials. Their effective elastic properties at different scales are of interest for computational studies of the MMT’s response to mechanical loading but also to realistically simulate implant osseointegration. We combine multi-scale and multi-modal experimental techniques with mathematical modelling of MMTs ...

Investigation of the Effect of Spinal Defects on Spondylolysis and Stress Fracture of Vertebral Bodies

M.S. Yeoman[1], C. Quah[2], A. Cizinauskas[1], K. Cooper[1], D. McNally[5], B. Boszczyk[2]
[1]Continuum Blue, Tredomen, Ystrad Mynach, United Kingdom
[2]The Centre for Spinal Studies and Surgery, Queen’s Medical Centre, Nottingham, United Kingdom
[5]Bioengineering Research Group, Faculty of Engineering, The University of Nottingham, Nottingham, United Kingdom

Spondylolysis (SL) is a defect of the spinal vertebra, and is typically caused by stress fracture of the pars interarticularis bone of the vertebral arch. It is especially common in adolescents who over train in sporting activities. Spina bifida occulta (SBO) is a malformation of the spine where the protruding vertebral bodies are not fully formed. In this study we demonstrate the predisposition ...

Cellular Scale Model of Stratum Corneum

R. Santoprete[1], B. Querleux[1]
[1]L'Oréal, Paris, France

To better quantify the impact of the morphological and mechanical properties of the main constituents of the stratum corneum (SC, the outermost layer of the skin) on its overall mechanical behavior, we developed a biomechanical model of the SC at a cellular scale, based on in vitro morphological and mechanical data. The sensitivity analysis quantified the relative impact of the mechanical and ...