Numerical Simulations Demonstrate Safe Vitrification and Warming of Embryos Using the Rapid-i™ Device
B.O.J. Johansson, Y.A. Tarakanov, H.J. Lehmann, and S.P. Apell
Department of Applied Physics, Chalmers University of Technology, Gothenburg, Sweden
Vitrolife Sweden AB, Västra Frölunda, Sweden
During cryopreservation of human embryos, ice crystal formation in the embryos or in surrounding media may cause cryodamage to them and can be lethal. A strategy to avoid this is the vitrification procedure when the embryo and the surrounding medium undergo the transition to glassy state rather than a crystalline one during cooling. Similarly, recrystallization in the embryo or the medium must ...
P. Apell, S. Hjalmarsson, T. Lindberg, I. Wernström, Y. Tarakonov, A. Erichsen Andersson, M. Karlsteen
Department of Applied Physics, Chalmers University of Technology, Göteborg, Sweden
Sahlgrenska University Hospital, Department of Anesthesia, Surgery and Intensive Care, Göteborg, Sweden
Patients undergoing surgery are sensitive to infections. The operation staff may spread 10^4 particles per person per minute, of which ten percent are presumed bacteria-carrying. We visualize the influence of the personnel on the air and particle flows for the two most common ventilation systems in Swedish hospitals using Comsol Multiphysics with particle tracing.. The Laminar Air flow ...
E. Bianchi, F. Bellati, E. Rollo, G. Dubini, C. Guiducci
Politecnico di Milano, LaBS, Laboratory of Biological Structure Mechanics, Milano, Italy
Swiss Federal Institute of Technology (EPFL), Laboratory of Life Sciences Electronics - Swiss Up Chair, Lausanne, Switzerland
A model of a cell counter sensor based on Impedance Spectroscopy (IS) has been implemented in COMSOL Multiphysics. The cell counter is a silicon-based microdevice consisting in 3D electrodes placed in a wide microchannel: cells flow in the microchannel through the electrodes to be detected. The model allows to evaluate the functionality of the device depending on geometrical parameters and ...
Search for a Suitable Numerical Model for Electrical Stimulation: from the Electric Double Layer to Electrokinetics, Confrontation with Impedance Measurements
P. Pham, R. Scapolan, C. Rubeck, and F. Dupont
CEA-LETI-MINATEC, Grenoble, France
Electrical Stimulation is widely used today for Deep Brain Stimulation treatments and retinal prostheses. The Electrical Double Layer formed at the interface between the electrode surface and the extracellular medium is considered thru the linear Helmholtz model and the nonlinear more realistic modified Poisson Boltzmann model. These different models, solved using COMSOL Multiphysics, are ...
Non-Newtonian Hemodynamics and Shear Stress Distribution in Three Dimensional Model of Healthy and Stented Coronary Artery Bifurcation
M.M. Zarandi, R. Mongrain, and O.F. Bertrand
McGill University, Montreal, QC, Canada
Laval University Quebec City, QC, Canada
In this paper, a three-dimensional model of the coronary artery bifurcation is developed and physiological flow in the both healthy and stented coronary artery bifurcation is modeled using COMSOL Multiphysics. Wall shear stress induced by endovascular stents in the coronary artery bifurcation is analyzed considering both non- Newtonian and Newtonian flow models. Our simulations shows that the ...
Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA
A key challenge to finding quantitative solutions to biological problems is to model the complex 3D geometry of naturally occurring structures. Model generation often starts from serial sections from CT or MRI scans, confocal microscopy, or physical sectioning. In addition, prior to V4 of COMSOL Multiphysics®, there was a "loft" command to allow construction of 3D models from serial sections ...
C. Nadovich[1, 2], W. D. Jemison, J. A. Stoute, C. Spadafora
Lafayette College, Easton, PA, USA
Clarkson University, Potsdam, NY, USA
Pennsylvania State University, Hershey, PA, USA
INDICASAT AIP, Ciudad del Saber, Panama
A computer controlled microwave exposure system and specialized applicators were constructed for the purpose of facilitating accurate observations of microwave radiation effects on uninfected and infected biological tissue in vitro and in vivo under different electromagnetic modalities and exposure configuration. To address diverse requirements, three different applicators were developed: a ...
Simulations of Heat and Mass Transport During Biomass Conversion Processes Using 3D Biomass Particle Models with Realistic Morphology and Resolved Microstructure - new
P. Ciesielski, M. Crowley, L. Thompson, B. Donohoe, D. Robichaud, A. Sanders, M. Nimlos, T. Foust
Biosciences Center, National Renewable Energy Laboratory, Golden, CO, USA
National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, USA
Quantum Electronics & Photonics Division, National Institute of Standards & Technology, Boulder, CO, USA
Predictive simulations of biomass conversion processes will improve their technical performance and reduce economic uncertainty surrounding industrialization of biofuels production. The majority of present conversion simulations treat the biomass feedstock with simplifying assumptions that neglect important characteristics that are unique to biomass particles. These characteristics, including ...
L. Garber[1,2], G. S. B. Williams, W. J. Lederer
Fischell Department of Bioengineering, University of Maryland, Baltimore, MD, USA
Center for Biomedical Engineering & Technology, University of Maryland, Baltimore, MD, USA
This project involves a simplified biological problem that was used to test the potential of COMSOL Multiphysics® software for cardiac myocyte spatial modeling. We made several assumptions to simplify the biological complexity and to highlight the geometrical structures (i.e., lack of sarcoplasmic reticulum, lack of contractile apparatus). We explored the role of the t-tubular network on ...
O. Nicotra, and A. La Magna
CNR-IMM Sezione di Catania, Catania, Italy
One of the major applications for dielectrophoresis is the selective trapping and fractionation in lab-on-a-chip devices. Nevertheless, many-particle effects due to high concentrations of biological material around electrodes can cause a rapid decrease of trapping efficiency in dielectrophoretic devices. In this contribution we present a new approach based on a drift-diffusion dynamics to study ...