Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

3-D Finite Element Modeling of Brain Edema: Initial Studies on Intracranial Pressure Using COMSOL Multiphysics®

X.G. Li[1], H. von Holst[1][2], J. Ho[1], and S. Kleiven[1]

[1]Division of Neuronic Engineering, KTH, Stockholm, Sweden
[2]Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden

Brain edema is one of the most common consequences of serious traumatic brain injuries which is usually accompanied with increased Intracranial Pressure (ICP) due to water content increment. A three dimensional finite element model of brain edema is used to study intracranial pressure in this paper. Three different boundary conditions at the end of Cerebral Spinal Fluid (CSF) were used to ...

血管对肿瘤的光热疗法的影响

吴淑莲 [1], 李晖 [2], 李志芳 [2],
[1] 福建师范大学,福州,中国
[2] 福建师范大学,福州,中国

引言:激光诱导间质肿瘤热疗法是一种可使生物组织局部地方凝结坏死的肿瘤疾病治疗方法,目前已经用于肝、脑等各部位的肿瘤治疗[1-2]。为了更好地进行肿瘤疾病的治疗,需要实时地对组织的温度和热损伤进行监控,而检测技术很难实现对肿瘤治疗过程的实时监测,故数值计算成为研究光热疗法的有力工具[2-6]。本模型将生物组织光传输的物理场与热传输的物理场相耦合,考虑组织光热参数随温度变化的情况,研究了肿瘤周围含有大动脉的情况时组织的温度分布随时间的变化情况,研究结果对指导临床医学肿瘤治疗有重要意义。 COMSOL Multiphysics® 的软件使用: 几何模型:如图1所示,圆柱代表光源,圆形区域代表肝脏肿瘤,弯曲圆柱代表大血管,大正方体代表肝脏。 PDE 接口和生物传热接口,选择生物组织的热损伤。 结果: 如图2,图3所示,在加热过程中,开始时血管对温度分布几乎无影响,但是随着加热时间变长 ...

Non-Newtonian Hemodynamics and Shear Stress Distribution in Three Dimensional Model of Healthy and Stented Coronary Artery Bifurcation

M.M. Zarandi[1], R. Mongrain[1], and O.F. Bertrand[2]
[1]McGill University, Montreal, QC, Canada
[2]Laval University Quebec City, QC, Canada

In this paper, a three-dimensional model of the coronary artery bifurcation is developed and physiological flow in the both healthy and stented coronary artery bifurcation is modeled using COMSOL Multiphysics. Wall shear stress induced by endovascular stents in the coronary artery bifurcation is analyzed considering both non- Newtonian and Newtonian flow models. Our simulations shows that the ...

Microvascular Dysfunction in PAD Patients - new

K. Cluff[1], H. Mehraein[1], B. Jayakumar[2]
[1]Department of Bioengineering, Wichita State University, Wichita, KS, USA
[2]Department of Industrial & Manufacturing Engineering, Wichita State University, Wichita, KS, USA

Background: Peripheral arterial disease (PAD) is characterized by atherosclerotic blockages of the arteries supplying the lower extremities, which cause a progressive accumulation of ischemic injury to the skeletal muscles of the lower limbs. Despite revascularization treatment intervention some PAD patients require follow up secondary treatment due to a continued decline in limb function, ...

Dried Reagent Resuspension for Point of Care Testing (Analysis at the Patient Bedside)

M. Huet [1],
[1] Department of Biotechnology, CEA/Université Grenoble-Alpes, Grenoble, France

A microfluidic component was designed to collect blood from a finger prick by capillary flow and to perform biological analysis. It was used to perform ABO blood typing experiments in one step, the blood drop deposit, by agglutination of red blood cells (RBC) using embedded dried reagents. The present study is a first step in the modeling of the whole agglutination assay. Blood typing ...

Computational Modeling to Study the Treatment of Cardiac Arrhythmias using Radiofrequency Ablation

A. González-Suárez[1], M. Trujillo[2], J. Koruth[3], A. D'Avila[3], E. Berjano[1]
[1]Biomedical Synergy, Electronic Engineering Department,Universitat Politècnica de Valencia, Valencia, Spain
[2]Instituto Universitario de Matemática Pura y Aplicada, Universitat Politècnica de Valencia, Valencia, Spain
[3]Helmsley Cardiac Electrophysiology Center, Mt SinaiMedicalCenter and School of Medicine, New York, NY, USA

Previous studies proposed using bipolar radiofrequency ablation across two catheters placed on opposing surfaces of the ventricular wall to create transmural lesions. 2D and 3D models were built and solved with COMSOL Multiphysics software. With these models, it was possible to study the temperature distribution and lesion geometry (Figure), to compare the potential of two ways of applying ...

Computational design and analysis of Microwave Tomography in Intracerebral Hemorrhage

Priyadarshini Natarajan [1], Rajkumar ElagiriRamalingam[1]
[1]Division of Biomedical Engineering, School of Biosciences and Technology, VIT University, Tamil Nadu, India

Intracerebral hemorrhage is a condition where a blood vessel in the brain ruptures and causes internal bleeding leading to hemorrhagic stroke. 800 in every 100,000 people suffer from stroke each year and it's one of the major causes of mortality worldwide. Diagnosis involves Neurological examination with MRI/CT scans which is costly and time consuming. Microwave Tomography (MWT) is proposed as a ...

Development of a Multiphase, Multispecies Droplet Evaporation Model for Optimization of Desiccation Preservation Techniques

A. Sinkevich[1], S. Bhowmick [1], M. Raessi[1]
[1]University of Massachusetts Dartmouth, North Dartmouth, MA, USA

Biopreservation deals with the protection and storage of complex biologics such as proteins, lipids, and recently, mammalian cells. One preservation method, known as lyopreservation, involves placing a biologic inside a water droplet with some type of sugar excipient (sucrose, trehalose, etc.) and drying the solution convectively. We are currently developing a model that couples the two-phase ...

Modeling of the Singlet Oxygen Distribution in Photofrin-Photodynamic Therapy of the Plural Cavity

R. Penjweini [1], T. C. Zhu [1], M. M. Kim [1],
[1] Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

Photofrin-mediated photodynamic therapy (PDT) is used after surgical resection at the University of Pennsylvania to treat the microscopic disease for malignant pleural mesothelioma and to increase survival rate. When Photofrin is exposed to laser light at 630 nm in well-oxygenated tissue, it produces reacted singlet oxygen ([1O2]rx) that kills cancer cells. As [1O2]rx is imperative to PDT ...

Numerical Prediction of Particle Dynamics Within a Cytometer. Application to Counting and Sizing by Impendance Measurement

D. Isèbe[1]
[1]HORIBA Medical, Montpellier, France

This paper describes how to numerically tackle the problem of counting and sizing particles by impedance measurement in an orifice–electrode system. The model simulate the particle dynamics submitted to strong hydrodynamic stresses through a microorifice and compute the voltage pulses generated by the modification of the inner dielectric medium. This FSI problem is solved on a moving mesh by ...