Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Local Electroporation of Single Adherent Cells by Micro-Structured Needle Electrodes

K. K. Sriperumbudur[1], P. J. Koester[1], M. Stubbe[1], C. Tautorat[1], J. Held[2], W. Baumann[1], and J. Gimsa[1]
[1] University of Rostock, Chair of Biophysics, Gertrudenstr. 11a, 18057 Rostock, Germany
[2] Microsystem Material Laboratory, Department of Microsystems Engineering (IMTEK), University of Freiburg, Germany

In spite of its low throughput, Patch-Clamp is the established method for intracellular measurements of the transmembrane potential. To address this problem, we have developed new biosensor-chips with micro-structured needle electrodes (MNEs). MNE-penetration of single cells growing on the MNE-tips leads to a situation comparable to the whole-cell mode in classical Patch Clamp. MNE-penetration ...

Simulation of Normal and Cancerous T-cell Membrane Electroporation - new

O. Henao[1], V. Gómez[1], I. De la Pava[1], J. Sánchez[1]
[1]Grupo Fisiología Celular y Aplicada, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia

Electroporation is an increase of the cell membrane permeability due to the formation of aqueous pores in it when the cell is under the influence of an intense electric field [1][2]. The formation of such pores in the membrane can be used to enhance the uptake of chemotherapeutic drugs into the cell in a cancer treatment known as electrochemotherapy [3]. In some cases the direct experimental ...

Simulations of Heat and Mass Transport During Biomass Conversion Processes Using 3D Biomass Particle Models with Realistic Morphology and Resolved Microstructure - new

P. Ciesielski[1], M. Crowley[1], L. Thompson[1], B. Donohoe[1], D. Robichaud[2], A. Sanders[3], M. Nimlos[2], T. Foust[2]
[1]Biosciences Center, National Renewable Energy Laboratory, Golden, CO, USA
[2]National Bioenergy Center, National Renewable Energy Laboratory, Golden, CO, USA
[3]Quantum Electronics & Photonics Division, National Institute of Standards & Technology, Boulder, CO, USA

Predictive simulations of biomass conversion processes will improve their technical performance and reduce economic uncertainty surrounding industrialization of biofuels production. The majority of present conversion simulations treat the biomass feedstock with simplifying assumptions that neglect important characteristics that are unique to biomass particles. These characteristics, including ...

Estudo Numérico da Eletroquimioterapia em Tumor Cutâneo com Diferentes Configurações de Eletrodos - new

G. Neves[1], D. Suzuki[1], J. Alvim[1], M. Rangel[2]
[1]Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil
[2]Vet Câncer Oncologia Veterinária, São Paulo, SP, Brasil

A eletroquimioterapia é um tratamento de câncer que utiliza a combinação de agentes quimioterápicos e campos elétricos. A base teórica por trás dessa aplicação é a eletroporação. Esse fenômeno biológico consiste na abertura de poros na membrana celular devido à aplicação de pulsos elétricos. Este trabalho analisa o comportamento do campo elétrico gerado por pulsos elétricos aplicados em ...

Computational Design and Optimization of Bone Tissue Engineering Scaffold Topology

N. P. Uth [1], J. Mueller [2], B. Smucker [3], A. Yousefi [1],
[1] Department of Chemical, Paper, and Biomedical Engineering, Miami University, Oxford, OH, USA
[2] Research Computing Support, Miami University, Oxford, OH, USA
[3] Department of Statistics, Miami University, Oxford, OH, USA

Introduction: Bone tissue has a limited ability for regeneration; critically sized defects cannot self-heal and require medical intervention. Bone tissue engineering (TE) circumvents this issue by growing replacement bone tissue from the patient’s own cells inside scaffolds. TE scaffolds are porous constructs that act as a support structure during bone regeneration and helps cells attach and ...

1D Axisymmetric Modeling of Shrinkage for Non-Porous Materials

J. M. Meot [1], A. Briffaz [1], J. Jacquin [2], S. Rashidi [2]
[1] Cirad, UMR QualiSud, Montpellier, France
[2] Bureau national Interprofessionnel du Pruneau, Villeneuve, France

A 1D-axisymmetric model was built to represent the drying of a single d’Ente plum to d’Agen prune. Underlying assumptions of the model were those of Di Matteo et al. 2003. Sorption isotherms of plum come from Tsami et al, 1990 and equation structure of apparent water diffusion coefficients from Sabarez, 2001. External transfer coefficients were adjusted by direct measurements. The parameters of ...

Passive and Active Deformation Processes of 3D Fibre-Reinforced Caricatures of Cardiovascular Tissues

A. Di Carlo[1], P. Nardinocchi[2], T. Svaton[3], and L. Teresi[1]

[1]Modelling and Simulation Lab, Università Roma Tre, Roma, Italy
[2]Dept. of Structural & Geotechnical Engineering, Università di Roma La Sapienza, Roma, Italy
[3]Dept. of Mathematics, University of West Bohemia, Pilsen, Czech Republic

In this paper, we present a mathematical model of contractile elastic solids meant to simulate various districts of the cardiovascular system, and based on the concepts of active deformation and embedded muscle fibres. Specifically, here we deal with the modeling of the gross mechanics of the Left Ventricle (LV) which is strictly related to its pump function. As is well known, the effectiveness ...

Photon Migration Through Multiple Layers of Biological Tissue

M.S. Yeoman[1], E. Sultan[2]
[1]Continuum Blue, Tredomen, Ystrad Mynach, United Kingdom
[2]College of Technological Studies, PAAET, Adailiyah, Kuwait

The modeling of light propagation through multiple layers of biological tissue are assessed & compared to the theoretical predictions by Perelman at al. [94 & 95] of the most-favorable-path (MFP). The MFP on which photons will be found can be obtained from the path of the net flux propagation using the diffusion equation. The diffusion equation is valid when studying diffuse light propagation, ...

Deposition of Submicron Charged Spherical Particles in the Trachea of the Human Airways

H.O. Åkerstedt[1]
[1]Luleå University of Technology, Luleå, Sweden

This paper presents a numerical study of the deposition of submicron charged spherical particles caused by convection, Brownian and turbulent diffusion in a pipe with a smooth wall and with a cartilaginous ring wall structure (see figure). The model is supposed to describe deposition of charged particles in generation 0 (trachea) of the human lung.The problem is defined by solving the fluid flow ...

An Assessment of the Suitability of the Body and Adult Head Coils for Transmission during Paediatric Magnetic Resonance Imaging

G.R. Cook[1], M.J. Graves[1], F.J. Robb[2], D.J. Lomas[1]
[1]Department of Radiology, University of Cambridge, Cambridge, United Kingdom
[2]General Electric Healthcare Coils, Aurora, Ohio, USA

MRI offers many advantages over other modalities and its lack of ionizing radiation is important for children, but can be limited by the radio-frequency (RF) coils available. This work calculates Specific Absorption Rate (SAR) and homogeneity of the RF transmit field (B1+) when imaging infants in adult coils. Two birdcage-type coils were loaded by a tissue model and their B1+ homogeneities ...