Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.
COMSOL News Magazine 2017

Simulations of Microelectrode and Neuron Interfaces Enable Long-Term and High Fidelity Recordings

P. Wijdenes [1], H. Ali [2], N. Syed [3], C. Dalton [2],
[1] Centre for Bioengineering Research and Education, University of Calgary, Calgary, AB, Canada
[2] Department of Electrical and Computer Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada
[3] Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada

Our inability to record single cell activity with high resolution over a long period of time precludes fundamental understanding of nervous system functions, both under normal and pathological conditions. While the fabrication of current micro- and nano-electrodes has advanced our capabilities to perform long-term recordings, this has been at the expense of signal resolution due to low sealing ...

Modeling of Nerve Stimulation Thresholds and Their Dependence on Electrical Impedance with COMSOL

P. Krastev[1], and B. Tracey[1]
[1]Neurometrix, Inc., Waltham, Massachusetts, USA

Nerve localization is important for applications in regional anesthesia. Localization is achieved by stimulating the nerve with an electric field produced by a current from a needle inserted into the body of the patient, close to the target nerve.  Modeling of the electric field in close proximity to the nerve may help to explain observed variations in threshold currents and can help to ...

Physical and FEM Simulation of Microprobe Insertion into Brain Tissue

A. Eed Olamat, U. Hofmann, B. Pohl, and N. Nkemasong
University of Lübeck, Institute for Signal Processing, Lübeck, Germany

In order to investigate the implantation of microprobes into brain tissue, we developed a finite-element and a physical model to replace real biological tissue for mechanical testing. Penetrating forces of a tungsten indenter into a layered structure was investigated with different indentation speeds. Numerical and physical model are in good correspondence to each other and reproduce measured ...

Modeling Arterial Drug Transport From Drug-eluting Stents: Effect of Blood Flow on the Concentration Distribution Close to the Endothelial Surface

F. Bozsak, J.-M. Chomaz, and A. I. Barakat
LadHyX, Ecole Polytechnique
Palaiseau, France

Drug-eluting stents (DES) are commonly used for treating coronary atherosclerosis. Despite the broad effectiveness of DES, ~5% of treated patients experience complications including in-stent restenosis and late-stent thrombosis. Furthermore, drugs used in DES not only inhibit proliferation of smooth muscle cells but also affect re-endothelialization. We have developed a computational model ...

A Mathematical Tool for Studying Drug Delivery to the Eye in Case of Glaucoma

P. Silva[1], J.A. Ferreira[2], P. de Oliveira[2]
[1]Coimbra Institute of Engineering, CMUC, Coimbra, Portugal
[2]Department of Mathematics University of Coimbra, CMUC, Coimbra, Portugal

The aim of the poster is to present a coupled 2D mathematical model to predict the evolution of drug concentration - in the cornea and in the anterior chamber of the eye - when therapeutic lenses are used (Figure 1). The mathematical model takes into account (i) diffusion processes in several compartments of the eye (therapeutic lens, cornea and anterior chamber); (ii) metabolic consuming ...

A Study on Nutrient Mass Transport through Porous Channeled Flat Sheet Membrane and Prediction of Maximum Scaffold Thickness for Viable Cell Culture (In-vitro) by 3D Modeling for Tissue Engineering Application

N. M. S. Bettahalli[1], B. J. Papenburg [2], D. S. Stamatialis [2], M. Wessling [3]
[1]University of Twente, Enschede, The Netherlands & BMS College of Engineering, Bangalore, India
[2]University of Twente, Enschede, The Netherlands
[3]RWTH Aachen University

Tissue engineering (TE) is a multidisciplinary field involving principles of engineering and life sciences to improve the health and quality of life by repairing, restoring, maintaining, or enhancing tissue and organ function using cells, scaffolds, and growth factors alone or in combination. There are several artificial tissues that are already being used which include fabricated skin, ...

Blood Flow Patterns in a Patient Specific Right Coronary Artery with Multiple Stenoses - new

B. Liu[1]
[1]Department of Mathematics, Monmouth University, West Long Branch, NJ, USA

Atherosclerotic lesions preferentially develop in certain regions like bifurcations, branches, and bends [1, 2]. A possible explanation for such a preferential localization of atherosclerosis is that the geometry of the vessel influences the blood flow pattern. It suggests that the arterial geometry plays an important role in determining the localized blood flow information. Thus hemodynamic ...

Kinetics of Proteins in the Blood-Brain Barrier

K. Gandhi [1],
[1] University of California, Riverside, CA, USA

The delivery of chemotherapy for cancer into the central nervous system, in particular the brain, remains a challenge. This results in brain metastases commonly being a cause of death from cancer. Here, we look at the environment of the blood-brain barrier. Then, we explore two proteins (breast cancer resistance protein and p-glycoprotein) that may inhibit the transport of medications (erlotinib ...

Virtual Thermal Ablation in the Head and Neck using COMSOL Multiphysics

U. Topaloglu[1], Y. Yan[2], P. Novak[2], P. Spring[3], J. Suen[3], and G. Shafirstein[3]
[1] Department of Information Technology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
[2]Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
[3]Department of Otolaryngology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Thermal ablation in the head and neck requires accurate thermal dose delivery to target tissue while protecting the structure and function of nearby tissue and organs. In this study, we present a method that allows importing Computed Tomography (CT) scans to COMSOL, in order to model accurately the expected pathological outcomes prior to thermal ablation treatment. Thermal ablation of a virtual ...

Advanced Modeling of a Lung-on-a-Chip Microdevice

M. J. Hancock [1], N. H. Elabbasi [1],
[1] Veryst Engineering, Needham, MA, USA

Organ-on-a-chip microdevices combine microfluidics, MEMS, and biotechnology techniques to mimic the multicellular architectures, tissue-tissue interfaces, physicochemical microenvironments, and vascular perfusion of the body.[1] Such devices are being developed to provide better levels of tissue and organ functionality compared with conventional cell culture systems, and have great potential to ...