Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Modeling of Retinal Electrical Stimulation Using a Micro Electrode Array Coupled with the Gouy-Chapman Electrical Double Layer Model to Investigate Stimulation Efficiency

F. Dupont, R. Scapolan, C. Condemine, J.F. Bêche, M. Belleville, and P. Pham
CEA, LETI, Minatec, Grenoble, France

The electrical stimulation for retinal implant has known significant improvements in the last decades with many implantations and experimentations. The ability to create better controlled and adapted signals to increase the efficiency in stimulation is a major objective. The aim of this study is to develop a numerical platform based on COMSOL Multiphysics to simulate different waveforms. The ...

Local Electroporation of Single Adherent Cells by Micro-Structured Needle Electrodes

K. K. Sriperumbudur[1], P. J. Koester[1], M. Stubbe[1], C. Tautorat[1], J. Held[2], W. Baumann[1], and J. Gimsa[1]
[1] University of Rostock, Chair of Biophysics, Gertrudenstr. 11a, 18057 Rostock, Germany
[2] Microsystem Material Laboratory, Department of Microsystems Engineering (IMTEK), University of Freiburg, Germany

In spite of its low throughput, Patch-Clamp is the established method for intracellular measurements of the transmembrane potential. To address this problem, we have developed new biosensor-chips with micro-structured needle electrodes (MNEs). MNE-penetration of single cells growing on the MNE-tips leads to a situation comparable to the whole-cell mode in classical Patch Clamp. MNE-penetration ...

A Mathematical Tool for Studying Drug Delivery to the Eye in Case of Glaucoma

P. Silva[1], J.A. Ferreira[2], P. de Oliveira[2]
[1]Coimbra Institute of Engineering, CMUC, Coimbra, Portugal
[2]Department of Mathematics University of Coimbra, CMUC, Coimbra, Portugal

The aim of the poster is to present a coupled 2D mathematical model to predict the evolution of drug concentration - in the cornea and in the anterior chamber of the eye - when therapeutic lenses are used (Figure 1). The mathematical model takes into account (i) diffusion processes in several compartments of the eye (therapeutic lens, cornea and anterior chamber); (ii) metabolic consuming ...

3D-FEA of the Relationship between the Occiput and Sphenoid in the Osteopathic Paradigm - new

Y. Chiesa[1]
[1]Istituto Superiore di Osteopatia, Milan, Italy

The concept of cranial Primary Respiratory Mechanism (MRP) is used by osteopathic practitioners to explain the perceptual characteristics arising from the clinical palpation approach of the human skull. The theoretical apparatus and the same MRP existence is always element of controversy among the scientific community. The results arising from this study highlight the intrinsic capability of ...

Simulation and Design of a Microfluidic Respirometer for Semi-Continuous Amperometric Short Time Biochemical Oxygen Demand (BODST) Analysis

F.J. del Campo[1], A. Torrents[1], J. Mas[2], F.X. Muñoz[1]
[1]Instituto de Microelectronica de Barcelona, IMB-CNM (CSIC), Campus Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
[2]Departement de Genètica i Microbiologia, Campus Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain

Introduction: This work presents the design of a novel flow cell based miniaturized electrochemical respirometer to monitor organic content in water samples semi-continuously, in contrast to current Biochemical Oxygen Demand, BOD, methods. Simulation techniques has been used to parameterize and optimize aspects such as height and length of the channels, materials and thickness, flow and oxygen ...

Modeling Bioclogging Effects in Constructed Wetlands for Wastewater Treatment - new

R. Samso[1], N. Forquet[2], P. Molle[2], J. Garcia[1]
[1]Department of Hydraulic, Maritime and Environmental Engineering, Universitat Politècnica de Catalunya-BarcelonaTech, Barcelona, Spain
[2]IRSTEA, Freshwater Systems, Ecology and Pollution Research Unit, Villeurbanne, France

Horizontal-Flow Constructed Wetlands (HFCWs) are a particular type of biofilter, and as such they rely mostly on the activity of bacterial communities to treat wastewater. Bacterial growth in HFCWs induces dramatic changes in its hydraulic and hydrodynamic behaviour (bioclogging), which may eventually result in overland flow of wastewater. Consequently, clogging is the main cause of premature ...

Microstimulation in The Brain: Does Microdialysis Inuence the Activated Volume of Tissue?

D. Krapohl[1][3], S. Loeffler[2], A. Moser[2], and U.G.Hofmann[1]

[1]Institute for Signalprocessing, University of Luebeck, Lübeck, Germany
[2]Institute for Neurology, University of Luebeck, Lübeck, Germany
[3]Department of Information Technology and Media, Mid Sweden University, Sundsvall, Sweden

Deep Brain Stimulation (DBS) has been established as an effective treatment for Parkinson's disease and other movement disorders. The stimulation is currently administered using tetrode-macroelectrodes that target the Subthalamic Nucleus (STN). This often leads to side effects which bias the surrounding areas, e.g. the speech centre. Targeting a specific brain region can better be achieved with ...

Modeling Interface Response in Cellular Adhesion

G. Megali[1], D. Pellicanò[1], M. Cacciola[1], F. Calarco[1], D. De Carlo[1], F. Laganà[1], and F.C. Morabito[1]

[1]DIMET Department, Faculty of Engineering, University “Mediterranea” of Reggio Calabria, Reggio Calabria, Italy

Constitutive properties of living cells are able to withstand physiological environment as well as mechanical stimuli occurring within and outside the body. We examined fluid flow and Neo-Hookean deformation related to the rolling effect. A mechanical model to describe the cellular adhesion with detachment is here proposed. We developed a finite element analysis, simulating blood cells attached ...

Solid Food Pasteurization by means of Ohmic Heating: Influence of Process Parameters

M. Zell[1], D. Cronin[1], D. Morgan[1], F. Marra[2], and J. Lyng[1]
[1]School of Agriculture, Food Science and Veterinary Medicine, Agriculture and Food Science Centre, College of Life Sciences, UCD Dublin, Ireland
[2]Dipartimento di Ingegneria Chimica e Alimentare, Università degli Studi di Salerno, Italy

Pasteurization of solid food undergoing ohmic heating has been analyzed using COMSOL Multiphysics on the basis of a previously validated multiphysics model. The simulation of pasteurization by ohmic heating involves simultaneous solution electrical potential within the food, heat transfer, and the kinetics transport of death of microorganisms. In the model, thermo-physical and electrical ...

The Effects of the Electrical Double Layer on Giant Ionic Currents through Single Walled Carbon Nanotubes

G. Zhang[1][,][2][,][3], S.L. Bearden [1]
[1]Department of Bioengineering, Clemson University, Clemson, SC, USA
[2]Department of Electrical and Computer Engineering, Clemson University, Clemson, SC, USA
[3]Institute for Biological Interfaces of Engineering, Clemson University, Clemson, SC, USA

Electrofluidic transport through a single walled carbon nanotube (SWCNT) is enhanced by electroosmosis. Electroosmosis is made possible in these devices by the combination of a large slip length within SWCNTs and the interfacial potential at the solution/nanotube interface. A computational model of a SWCNT device was developed using COMSOL Multiphysics to investigate the complete electrical ...