Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA
A key challenge to finding quantitative solutions to biological problems is to model the complex 3D geometry of naturally occurring structures. Model generation often starts from serial sections from CT or MRI scans, confocal microscopy, or physical sectioning. In addition, prior to V4 of COMSOL Multiphysics®, there was a "loft" command to allow construction of 3D models from serial sections ...
N.S. Lawand, J. van Driel, P.J. French
Electronic Instrumentation Laboratory (EILab), Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS), Delft University of Technology, Delft, The Netherlands
Delft University of Technology, Delft, The Netherlands
Cochlear Implants are implantable devices which bypasses the non-functional inner ear and directly stimulates the hearing nerve with electric currents thus enabling deaf people to experience sound again. Implant electrode array design is limited in electrode count, due to their large size in accordance to scala tympani (ST) with restrictions for deeper insertion in ST thus depriving access to ...
P. Pattanaik, S. K. Kamilla, D. P. Das, S. K. Pradhan
MEMS Design Center, Institute of Technical Education & Research (ITER), Sikhya ‘O’ Anushandhan University, Bhubaneswar, Odisha, India
Process Engineering and Instrumentation Lab, Institute of Minerals and Materials Technology (IMMT), Bhubaneswar, Odisha, India
Dept of ECE, Hi-Tech Institute of Technology, Khurda, Odisha, India
This paper describes the design of an ultrasonic transducer using different lead free piezo-electric materials and evaluates their performance with different glucose levels in the human blood. COMSOL Multiphysics 4.2a was used for the simulation study using 2D axis symmetric model of piezoelectric transducer which was designed with lead free piezoelectric materials such as Barium Sodium Niobate ...
K. Carlson [1,], J. Begnaud , J. L. Shils , S. Dokos , L. Mei [1,], J. E. Arle [1,]
 Beth Israel Deaconess Medical Center, Boston, MA, USA
 Harvard Medical School, Boston, MA, USA
 Livanova Neuromodulation, Houston, TX, USA
 Rush Medical Center, Chicago, IL, USA
 University of New South Wales, Sydney, NSW, Australia
Neuromodulation is the use of electromagnetic fields to modulate the human nervous system, typically to treat neurological disorders. Electroceuticals is an ambitious program to modulate any nerve, anywhere, anytime, for any reason — to treat disease, disorders, and enhance or interface with the nervous system. Note that electroceuticals follows medical devices’, rather than pharmaceuticals’, ...
Evaluating Nanogaps in Ag and Au Nanoparticle Clusters for SERS Applications Using COMSOL Multiphysics®
R. Asapu , R. Ciocarlan , N. Claes , N. Blommaerts , S. Bals , P. Cool , S. Denys , S. Lenaerts , S. W. Verbruggen 
 Department of Bioscience Engineering, DuEL Research Group, University of Antwerp, Belgium
 Department of Chemistry, PLASMANT Research Group, University of Antwerp, Belgium
 Department of Physics, EMAT Research Group, University of Antwerp, Belgium
Silver and gold nanoparticles are widely used in the field of surface enhanced raman spectroscopy (SERS) because of the unique plasmonic properties. Plasmons or surface plasmon resonance result from the wavelength dependent dielectric properties of noble metals like Ag, Au, Pt etc., which give rise to enhanced near-electric field which is the primary reason for enhancement of Raman signal in ...
Priyadarshini Natarajan , Rajkumar ElagiriRamalingam
Division of Biomedical Engineering, School of Biosciences and Technology, VIT University, Tamil Nadu, India
Intracerebral hemorrhage is a condition where a blood vessel in the brain ruptures and causes internal bleeding leading to hemorrhagic stroke. 800 in every 100,000 people suffer from stroke each year and it's one of the major causes of mortality worldwide. Diagnosis involves Neurological examination with MRI/CT scans which is costly and time consuming. Microwave Tomography (MWT) is proposed as a ...
P. Wijdenes , H. Ali , N. Syed , C. Dalton ,
 Centre for Bioengineering Research and Education, University of Calgary, Calgary, AB, Canada
 Department of Electrical and Computer Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada
 Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada
Our inability to record single cell activity with high resolution over a long period of time precludes fundamental understanding of nervous system functions, both under normal and pathological conditions. While the fabrication of current micro- and nano-electrodes has advanced our capabilities to perform long-term recordings, this has been at the expense of signal resolution due to low sealing ...
M. Nickaeen , I. L. Novak , A. Mogilner , B. M. Slepchenko ,
 Richard D. Berlin Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, CT, USA
 Courant Institute and Department of Biology, New York University, New York, NY, USA
A recently published conservative algorithm for simulating reactions and transport in moving domains have been extended to models in which cell kinematics are coupled with intracellular dynamics. For this, the method that combines a Eulerian approach with tracking an explicit boundary was linked to FronTier, a robust front-tracking technique. The extended algorithm was validated using a set of ...
K. Gandhi ,
 University of California, Riverside, CA, USA
The delivery of chemotherapy for cancer into the central nervous system, in particular the brain, remains a challenge. This results in brain metastases commonly being a cause of death from cancer. Here, we look at the environment of the blood-brain barrier. Then, we explore two proteins (breast cancer resistance protein and p-glycoprotein) that may inhibit the transport of medications (erlotinib ...
K. Carlson , J. Arle , J. L. Shils , L. Mei ,
 Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, MA, USA
 Rush Medical Center, Chicago, IL, USA
In 1901 Weiss proposed an equation predicting activation of nerve fibers by electrical stimulation, used in neuroscience and neuromodulation, which applies electric fields to modify nerve behavior in neurological disorders. Weiss’ equation is relative to geometry, electrode array, tissue conductivities, and waveform since it uses electrode amplitude. We replicated a leading calibrated nerve ...