Modeling of Retinal Electrical Stimulation Using a Micro Electrode Array Coupled with the Gouy-Chapman Electrical Double Layer Model to Investigate Stimulation Efficiency
F. Dupont, R. Scapolan, C. Condemine, J.F. Bêche, M. Belleville, and P. Pham
CEA, LETI, Minatec, Grenoble, France
The electrical stimulation for retinal implant has known significant improvements in the last decades with many implantations and experimentations. The ability to create better controlled and adapted signals to increase the efficiency in stimulation is a major objective. The aim of this study is to develop a numerical platform based on COMSOL Multiphysics to simulate different waveforms. The ...
K. K. Sriperumbudur, P. J. Koester, M. Stubbe, C. Tautorat, J. Held, W. Baumann, and J. Gimsa
 University of Rostock, Chair of Biophysics, Gertrudenstr. 11a, 18057 Rostock, Germany
 Microsystem Material Laboratory, Department of Microsystems Engineering (IMTEK), University of Freiburg, Germany
In spite of its low throughput, Patch-Clamp is the established method for intracellular measurements of the transmembrane potential. To address this problem, we have developed new biosensor-chips with micro-structured needle electrodes (MNEs). MNE-penetration of single cells growing on the MNE-tips leads to a situation comparable to the whole-cell mode in classical Patch Clamp. MNE-penetration ...
P. Silva, J.A. Ferreira, P. de Oliveira
Coimbra Institute of Engineering, CMUC, Coimbra, Portugal
Department of Mathematics University of Coimbra, CMUC, Coimbra, Portugal
The aim of the poster is to present a coupled 2D mathematical model to predict the evolution of drug concentration - in the cornea and in the anterior chamber of the eye - when therapeutic lenses are used (Figure 1). The mathematical model takes into account (i) diffusion processes in several compartments of the eye (therapeutic lens, cornea and anterior chamber); (ii) metabolic consuming ...
Istituto Superiore di Osteopatia, Milan, Italy
The concept of cranial Primary Respiratory Mechanism (MRP) is used by osteopathic practitioners to explain the perceptual characteristics arising from the clinical palpation approach of the human skull. The theoretical apparatus and the same MRP existence is always element of controversy among the scientific community. The results arising from this study highlight the intrinsic capability of ...
Simulation and Design of a Microfluidic Respirometer for Semi-Continuous Amperometric Short Time Biochemical Oxygen Demand (BODST) Analysis
F.J. del Campo, A. Torrents, J. Mas, F.X. Muñoz
Instituto de Microelectronica de Barcelona, IMB-CNM (CSIC), Campus Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
Departement de Genètica i Microbiologia, Campus Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain
Introduction: This work presents the design of a novel flow cell based miniaturized electrochemical respirometer to monitor organic content in water samples semi-continuously, in contrast to current Biochemical Oxygen Demand, BOD, methods. Simulation techniques has been used to parameterize and optimize aspects such as height and length of the channels, materials and thickness, flow and oxygen ...
R. Samso, N. Forquet, P. Molle, J. Garcia
Department of Hydraulic, Maritime and Environmental Engineering, Universitat Politècnica de Catalunya-BarcelonaTech, Barcelona, Spain
IRSTEA, Freshwater Systems, Ecology and Pollution Research Unit, Villeurbanne, France
Horizontal-Flow Constructed Wetlands (HFCWs) are a particular type of biofilter, and as such they rely mostly on the activity of bacterial communities to treat wastewater. Bacterial growth in HFCWs induces dramatic changes in its hydraulic and hydrodynamic behaviour (bioclogging), which may eventually result in overland flow of wastewater. Consequently, clogging is the main cause of premature ...
D. Krapohl, S. Loeffler, A. Moser, and U.G.Hofmann
Institute for Signalprocessing, University of Luebeck, Lübeck, Germany
Institute for Neurology, University of Luebeck, Lübeck, Germany
Department of Information Technology and Media, Mid Sweden University, Sundsvall, Sweden
Deep Brain Stimulation (DBS) has been established as an effective treatment for Parkinson's disease and other movement disorders. The stimulation is currently administered using tetrode-macroelectrodes that target the Subthalamic Nucleus (STN). This often leads to side effects which bias the surrounding areas, e.g. the speech centre. Targeting a specific brain region can better be achieved with ...
G. Megali, D. Pellicanò, M. Cacciola, F. Calarco, D. De Carlo, F. Laganà, and F.C. Morabito
DIMET Department, Faculty of Engineering, University “Mediterranea” of Reggio Calabria, Reggio Calabria, Italy
Constitutive properties of living cells are able to withstand physiological environment as well as mechanical stimuli occurring within and outside the body. We examined fluid flow and Neo-Hookean deformation related to the rolling effect. A mechanical model to describe the cellular adhesion with detachment is here proposed. We developed a finite element analysis, simulating blood cells attached ...
M. Zell, D. Cronin, D. Morgan, F. Marra, and J. Lyng
School of Agriculture, Food Science and Veterinary Medicine, Agriculture and Food Science Centre, College of Life Sciences, UCD Dublin, Ireland
Dipartimento di Ingegneria Chimica e Alimentare, Università degli Studi di Salerno, Italy
Pasteurization of solid food undergoing ohmic heating has been analyzed using COMSOL Multiphysics on the basis of a previously validated multiphysics model. The simulation of pasteurization by ohmic heating involves simultaneous solution electrical potential within the food, heat transfer, and the kinetics transport of death of microorganisms. In the model, thermo-physical and electrical ...
The Effects of the Electrical Double Layer on Giant Ionic Currents through Single Walled Carbon Nanotubes
G. Zhang[,][,], S.L. Bearden 
Department of Bioengineering, Clemson University, Clemson, SC, USA
Department of Electrical and Computer Engineering, Clemson University, Clemson, SC, USA
Institute for Biological Interfaces of Engineering, Clemson University, Clemson, SC, USA
Electrofluidic transport through a single walled carbon nanotube (SWCNT) is enhanced by electroosmosis. Electroosmosis is made possible in these devices by the combination of a large slip length within SWCNTs and the interfacial potential at the solution/nanotube interface. A computational model of a SWCNT device was developed using COMSOL Multiphysics to investigate the complete electrical ...