A Method for Efficient Calculation of Diffusion and Reactions of Lipophilic Compounds in Complex Cell Geometry
Kristian Dreij, Qasim Ali Chaudhry, Bengt Jernström, Ralf Morgenstern, and Michael Hanke
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden
A general description of effects of toxic compounds in mammalian cells is facing several problems. Firstly, most toxic compounds are hydrophobic and partition phenomena strongly influence their behaviour. Secondly, cells display considerable heterogeneity regarding the presence, activity and distribution of enzymes participating in the metabolism of foreign compounds i.e. bioactivation ...
J. C. Kumaradas, A. Zhang, Y. D. Davletshin
Ryerson University, Toronto, ON, Canada
University of Waterloo, Waterloo, ON, Canada
Tremendous progress is being made in the integration of nanoparticles into micro-analytical systems for biosensing. These materials are shown to enhance the analyte capture capability of biosensing platforms. We have implemented a computational model that considers the sensor’s geometry, size, analyte concentration and type to predict the number of nucleic acid molecules captured by ...
P. Guha, P. Sharma, V. Malhotra, S. Mishra
CSIR - Central Scientific Instruments Organisation, Chandigarh, India
Proper storage of grains depends on minimizing attacks of insects, fungi, mites, etc. Development of such pests can be controlled by controlling the temperature of the storage chamber. Hence, before designing grain storage chambers, mathematical modeling and numerical simulations should be performed to predict the temperature distributions. Changes in storage temperature may occur due to several ...
K. Gandhi ,
 University of California, Riverside, CA, USA
The delivery of chemotherapy for cancer into the central nervous system, in particular the brain, remains a challenge. This results in brain metastases commonly being a cause of death from cancer. Here, we look at the environment of the blood-brain barrier. Then, we explore two proteins (breast cancer resistance protein and p-glycoprotein) that may inhibit the transport of medications (erlotinib ...
Zhifang Li , Xiyang Zhang ,
 College of Photonic and Electronic Engineering, Fujian Normal University, Fuzhou, China
Laser immunotherapy (LIT) was developed to treat late-stage, metastatic cancers through local laser irradiation and immunological stimulation. In ILIT, the photothermal effect induces immune responses by destroying and interrupting tumor cells through temperature elevation in target tissue. Tumor is rich in vascularture, and plays a critical part in photothermal effect. Vascularized tumour ...
P. Krastev, and B. Tracey
Neurometrix, Inc., Waltham, Massachusetts, USA
Nerve localization is important for applications in regional anesthesia. Localization is achieved by stimulating the nerve with an electric field produced by a current from a needle inserted into the body of the patient, close to the target nerve. Modeling of the electric field in close proximity to the nerve may help to explain observed variations in threshold currents and can help to ...
Numerical Simulation of the Functional Electromagnetic Stimulation of the Human Femoral Bone using COMSOL
Y. Haba, W. Kröger, H. Ewald, R. Souffrant, W. Mittelmeier, and R. Bader
Biomechanics and Implant Technology Research Laboratory, Department of Orthopaedics, University of Rostock, Rostock, Germany
Institute of General Electrical Engineering, University of Rostock, Rostock, Germany
In the present study we determined the relative conductivities and permittivities of fresh cortical and cancellous bone measuring human femoral heads in different slices of 1 mm thickness. The identified conductivities of human trabecular bone are used for the electromagnetic field simulation by means of COMSOL using a Micro-Computed Tomography (Micro-CT) model. The calculated model depends on a ...
A. Chanda, A.R. Choudhury, G. Ray, K. Dasgupta, and D. Nag
Jadavpur University, Kolkata, West Bengal, India
Atherosclerosis in arteries is caused by the formation of stenosis : fatty depositions, on the artery wall. In current medicine, the practice is to observe the maximum percentage occlusion at any arbitrary cross-section and diagnose the patient on that basis, which might not always present the real picture due to non-uniformity of the stenosis thickness. The present work attempts to simulate the ...
R. Santoprete, B. Querleux
L'Oréal, Paris, France
To better quantify the impact of the morphological and mechanical properties of the main constituents of the stratum corneum (SC, the outermost layer of the skin) on its overall mechanical behavior, we developed a biomechanical model of the SC at a cellular scale, based on in vitro morphological and mechanical data. The sensitivity analysis quantified the relative impact of the mechanical and ...
C. Soares, N. Padoin, F. Montalvo, D. Cobra
Federal University of Santa Catarina, Florianópolis, SC, Brazil
CERTI Foundation, Florianópolis, SC, Brazil
Schistosoma mansoni parasites affect million people worldwide. The intensity of the infection can be evaluated by the number of eggs present in the stool of an infected individual. The application of the traditional methods has been regarded as impractical in developing areas and there is a continuous search for new techniques. In face of this scenario, a new method of diagnosis was explored in ...