Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Computationally Assisted Design and Experimental Validation of a Novel ‘Flow-Focussed’ Microfluidics Chip for Generating Monodisperse Microbubbles

M. Conneely[1], V. Hegde[2], H. Rolfsnes[1], A. Mason[2], D. McLean[1], C. Main[1], F.J.D. Smith[2], W.H.I. McLean[2], P.A. Campbell[1]
[1]Carnegie Physics Laboratory, University of Dundee, Dundee, Scotland, United Kingdom
[2]Division of Molecular Medicine, University of Dundee, Dundee, Scotland, United Kingdom

Whilst initially developed as a diagnostic aid to improve echogenicity in ultrasound imaging, gas-filled lipid microbubbles are now emerging as a next generation \'theranostic\' tool in the medical arena. Here, their therapeutic potential has now been realized through their unique capability to deliver molecular species such as drugs and genes by means of disrupting the cell membrane in response ...

Extending Engineering Simulations to Scientists: Food Safety and Quality Prediction Using COMSOL Multiphysics® and LiveLink™ for Excel®

A. Warning[1], A. K. Datta[1]
[1]Cornell University, Ithaca, NY, USA

The objective of this study was to develop an easy to use interface in Excel® that connects to not only the solvers in COMSOL Multiphysics®, but also existing databases of food properties, foodborne pathogenic microorganisms kinetics, and chemical kinetics, creating a comprehensive simulation software to predict food safety and quality. The user interface allows the user to select the food, ...

Modeling Bacterial Clearance Using Stochastic-Differential Equations

A. Jeremic, and A. Atalla
McMaster University, Hamilton, ON, Canada

In this paper, we develop a mathematical model to simulate the movement of bacteria into and within a capillary segment. Also, we model the transportation through capillary walls by means of anisotropic diffusivity that depends on the pressure difference across the capillary walls. By solving the model using COMSOL, it was possible to predict the concentration of bacteria at points within the ...

3-Dimensional Blood Cooling Model inside a Carotid Bifurcation

R. Sikorski[1], T. Merrill[1]
[1]Rowan University, Glassboro, NJ, USA

Stroke is caused by an interruption of brain blood supply and is one of the leading causes of death and disability. A mild reduction of 2-5°C in tissue temperature through hypothermia has shown reduced tissue infarct size, increased tissue recovery, and positive neurological effects. This paper seeks to predict the outlet blood temperature in the common carotid bifurcation branches. In our ...

Drug Distribution in the Human Eye

L. Murtomäki[1], T. Kainuvaara[1]
[1]University of Helsinki, Helsinki, Finland

Drug therapy of the posterior segment of an eye is very challenging due to the difficult accessibility. Modern drugs often are large molecules, such as peptides, antibodies or oligonucleotides which are administrated, e.g. by intravitreous injections which requires clinical conditions. Computer modeling can be helpful in designing new and less invasive routes of drug administration. COMSOL is ...

Image-Based Simulation of Electrical Impedance Techniques Applied on the Human Thorax for Cardio-Pulmonary Applications

F.K. Hermans[1], R.M. Heethaar[1], R.T. Cotton[2], and A. Harkara[2]

[1]VU University Medical Center, Amsterdam, The Netherlands
[2]Simpleware Ltd., Exeter, United Kingdom

For medical diagnostic purposes there is an increasing need for non- (or minimal) invasive techniques to measure all kinds of parameters that can provide insight in the functioning of cells, organs or organ systems. Currently, Impedance Cardiography (ICG) is used for measurements of the heart and Electric Impedance Tomography (EIT) is used for investigating lung tissue condition. This paper ...

Blood Flow Patterns in a Patient Specific Right Coronary Artery with Multiple Stenoses - new

B. Liu[1]
[1]Department of Mathematics, Monmouth University, West Long Branch, NJ, USA

Atherosclerotic lesions preferentially develop in certain regions like bifurcations, branches, and bends [1, 2]. A possible explanation for such a preferential localization of atherosclerosis is that the geometry of the vessel influences the blood flow pattern. It suggests that the arterial geometry plays an important role in determining the localized blood flow information. Thus hemodynamic ...

Thermal-Optical Modeling of a Signal Enhancement Approach for Paper-Based Diagnostics

D. Gasperino [1]
[1] Intellectual Ventures Laboratory, Bellevue, WA, USA

INTRODUCTION: Point of care diagnostics aimed at low-resource settings need to be relatively simple, robust and low-cost. The most commonly-used diagnostic platform in these settings is the lateral flow assay (LFA). LFAs are paper-based immunoassays designed to perform on-strip binding with analytes in patient samples in order to generate a visual signal if disease-specific antigen is ...

Energy Harvesting from Variation in Blood Pressure through Deformation of Arterial Wall using Electro-magneto-hydrodynamics

A. Pfenniger[1], V.M. Koch[2], A. Stahel[2], and R. Vogel[1]
[1]ARTORG Cardiovascular Engineering, University of Bern, Bern, Switzerland
[2]Bern University of Applied Sciences, Engineering and Information Technology, Biel, Switzerland

The present project aims at modelling a generator that harvests energy from the variation in blood pressure by exploiting the motion of the arterial wall between the diastolic and systolic phase of the cardiac cycle. The concept is to use a highly electrically conductive fluid, which is driven by the motion of the arterial wall within a separate compartment outside the artery. A constant ...

An Elastic and Hyperelastic Material Model of Joint Cartilage - Calculation of the Pressure Dependent Material Stress in Joint Cartilage

T. Reuter, and M. Hoffmann
fzmb GmbH
Research Centre of Medical Technology and Biotechnology
Bad Langensalza, Germany

In this paper we introduce a elastic and hyperelastic model to describe the pressure dependent material stress in joint cartilage. We used the pressure dependent E-modulus E = f(s) to calculate the material stress. E = f(s) is a degree 4 polynomial . The indentor was pressed 0.4 mm into the tissue. The results show that the maximal stress at the contact zone between indentor and cartilage ...