Advancing Regulatory Science through Integrative Engineering with COMSOL Multiphysics® Software Modeling
G. Zhang 
 Department of Bioengineering, Institute for Biological Interfaces of Engineering, Clemson University, Clemson, SC, USA
The US Food and Drug Administration (FDA) faces significant challenges in its regulatory approval processes due to a lack of relevant science, and many practices are limited by laws enacted in the previous century . Therefore, in recent years, the FDA has identified the need for advancements in regulatory science and innovation. In a broader sense, advancing regulatory science is not just ...
G. Bonmassar, and A. Golby
AA. Martinos Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Department of Neurosurgery, Brigham and Women’s Hospital, Boston, Massachusetts, USA
A new type of MRI compatible intracranial electrode based on Polymer Thick Film (PTF) is presented and studied using COMSOL Multiphysics. The geometry considered was a two-dimensional cross section cut of 5 mm thick electrodes with 5 cm leads on top of a 2×10 cm slab representing Gelfilm, or the substrate. The resistive leads were compared with metallic leads to estimate the ...
H.H. Chen-Mayer, and R. Tosh
Ionizing Radiation Division, National Institute of Standards and Technology, Gaithersburg, Maryland, USA
Water calorimetry is employed to establish a primary reference standard for radiation dosimetry by measuring the temperature rises in a water phantom (a cube of about 30 cm x 30 cm x 30 cm) subjected to a beam of ionizing radiation. We use COMSOL Multiphysics to model the system using the Heat Transfer module and the Incompressible Navier-Stokes module with a geometry of 2D-axial ...
Q.A. Chaudhry, M. Hanke, and R. Morgenstern
School of Computer Science and Communication, Royal Institute of Technology, Stockholm, Sweden
Karolinska Institutet, Stockholm, Sweden
The mathematical modeling of the diffusion and reaction of toxic compounds in mammalian cells is tough task due to their very complex geometry. The heterogeneity of the cell, particularly the cytoplasm, and the variation of the cellular architecture, greatly affects the behavior of these toxic compounds. Homogenization techniques have been implemented for the numerical treatment of the model. ...
A. N. Kolborg ,
 Technical University of Denmark, Lyngby, Denmark
This project makes a first attempt at modelling fluid flow over shark skin on a microscopic level. The modeled fluid flow shows good agreement with theory. Further refinement of the model parameters holds promises of better understanding of this complex fluid flow phenomenon. The COMSOL Multiphysics® model was evaluated against micro particle image velocimetry measurements of the same flow ...
J. Bergstrom , N. Elabbasi ,
 Veryst Engineering, Needham, MA, USA
The use of thermoplastic materials is increasing and it is becoming more important during the design process to accurately represent the non-linear material response in relevant loading conditions. The COMSOL Multiphysics® software supports advanced modeling capabilities for large deformation analyses, including contact and multiphysics couplings. It is now also possible to use advanced non ...
I. Claydon , J. Turner , B. Sammakia ,
 Binghamton University, Binghamton, NY, USA
The ubiquitous nature of biofilms has led to a growing need to be able to detect, control, and maintain or remove them. Therefore a robust testing platform that allows for multiple analytical techniques is required to better understand their multitude of properties. The development of the self-contained microfluidic-based electrochemical cell portion of a multifaceted analysis system is ...
A. Gizzi, C. Cherubini, S. Migliori, and S. Filippi
Nonlinear Physics and Mathematical Modeling Lab, Engineering Faculty, University Campus Bio-Medico, Roma, Italy
International Center for Relativistic Astrophysics, University of Rome La Sapienza, Roma, Italy
Alberto Sordi Foundation, Research Institute on Aging, Roma, Italy
Postoperative or paralytic Ileus (PI) is a temporary aftermath of major abdominal surgeries. PI prevents the passage of food throughout the lumen leading to bloating, distension, emesis and pain. A plausible mathematical model for this phenomenology physiologically fine tuned including thermal variations, is presented here. Using COMSOL Multiphysics the existing intestinal ionic model have been ...
A. Gerisch, S. Tiburtius, Q. Grimal, and K. Raum
Technische Universität Darmstadt, Darmstadt, Germany
Laboratoire d’Imagerie Paramétrique, UPMC, Paris, France
Julius Wolff Institut & Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany
Musculoskeletal mineralized tissues (MMTs), e.g. bone, are hierarchical composite materials. Their effective elastic properties at different scales are of interest for computational studies of the MMT’s response to mechanical loading but also to realistically simulate implant osseointegration. We combine multi-scale and multi-modal experimental techniques with mathematical modelling of MMTs ...
A. Altamirano, C. Toledo, A. Vera, R. Muñoz, and L. Leija
Centro de Investigacion y Estudios Avanzados
Instituto Politecnico Nacional
In this article, the aim is to study different types and forms of electromyography (EMG) electrodes, for bipolar configuration, and the electric interface with muscle phantom. COMSOL Multiphysics allows modeling shapes and contact surfaces. Surface and needle electrodes will be modeled. A number of different trials and combinations will be presented; exploring different geometric shapes and ...