J. Parikh, A. Kapela, N. Tsoukias
Biomedical Engineering Department, Florida International University, Miami, FL, USA
Localized calcium events in the endothelial cells (EC) can modulate smooth muscle cell (SMC) calcium (Ca2+) and membrane potential dynamics through release of endothelium derived hyperpolarizing and relaxing factors. Ca2+ levels in the smooth muscle cell (SMC) determine its contractile state.The underlying complex mechanism regulating the SMC Ca2+ levels and ultimately vessel tone remains poorly ...
Department of Chemical Engineering, University of Arkansas, Fayetteville, AR, USA
During the hydraulic fracturing process, there can be possible re-activation of closed/sealed faults and natural fractures in the formation, which may lead to changes in the boundary conditions of the reservoir. While study models of shale gas formations have utilized the concept of a closed reservoir in order to optimize the production of gas in the well-bore, this assumption cannot be adopted ...
A. Warning , A. K. Datta ,
 Cornell University, Ithaca, NY, USA
The particle tracking model provided a deeper understanding to the experimental results. The model showed good agreement with experimental data for rotation, transport and attachment. In the attachment model, protrusions create low velocity, low shear regions increasing attachment while holes pull cells toward the surface and increase residence time on the surface increasing attachment rate.
Modelling and Simulation of Single Phase Fluid Flow and Heat Transfer in Packed Beds using COMSOL Multiphysics
S. Sachdev, S. Pareek, B. Mahadevan, A. Deshpande
Department of Chemical Engineering, BITS Pilani Goa Campus, Zuarinagar, Goa, India
Computational fluid dynamics has emerged as an advanced tool for studying detailed behavior of fluid flow and heat transfer characteristics in many chemical engineering applications like packed beds. Packed beds play an important role in various chemical industries. Hence understanding the fluid flow behavior and temperature variation in different sections of packed bed is essential. Geometric ...
P. Silva, J.A. Ferreira, P. de Oliveira
Coimbra Institute of Engineering, CMUC, Coimbra, Portugal
Department of Mathematics University of Coimbra, CMUC, Coimbra, Portugal
The aim of the poster is to present a coupled 2D mathematical model to predict the evolution of drug concentration - in the cornea and in the anterior chamber of the eye - when therapeutic lenses are used (Figure 1). The mathematical model takes into account (i) diffusion processes in several compartments of the eye (therapeutic lens, cornea and anterior chamber); (ii) metabolic consuming ...
S. Mahajani, S. Srikantiah, G. Samdani, A. Ganesh, P. Aghalayam
Department of Chemical Engineering, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India
Indian Institute of Technology Madras, Chennai, India
UCG is a process which converts coal to syn gas at the underground coal seam itself. UCG can help meeting the rising energy demand by utilizing coal resources that otherwise would be too deep, or of poor quality, or simply not economical to mine. As UCG takes place, a cavity is formed underground in the coal seam which grows three-dimensionally. The objective of this work is to develop a two ...
E. Laurenz, G. Füldner, L. Schnabel
Fraunhofer Institute for Solar Energy Systems (ISE), Freiburg, Germany
Adsorption heat exchangers (AdHXs) are important components in adsorption heat pumps and chillers, a primary energy efficient source of heating and cooling. Due to availability and established inexpensive manufacturing fin-and-tube type heat exchangers with beds of adsorption pellets in the finned space are widely used in state of the art products (Figure 1). For design and optimization the ...
V. Runkana, A. Pareek, P. Arora
Tata Consultancy Services, Pune, Maharashtra, India
Indian Institute of Technology Delhi, New Delhi, Delhi, India
Limited drug efficacy, undesirable temporal changes in drug concentration and patient non-compliance due to frequent dosing schedule have given impetus to design of controlled drug release systems . Biodegradable polymers due to their favorable and tunable properties and biocompatibility have found widespread use in the field of controlled drug delivery . Exploratory in vitro experiments ...
A. Hallgarth, A. Zayer, A. Gatward, and J. Davies
Hazard Research & Risk Consultants Ltd, Aberystwyth, Wales, United Kingdom
Independent Consultants, United Kingdom
HazRes has developed a gas discharge and dispersion model in COMSOL which takes into account the effects of localized wind profiles and turbulence generated by buildings, structures and terrain on the dispersion of gases in question. The main focus of this work is to develop and provide clients with more accurate prediction methods relative to industrial standard software tools in modeling ...
Theoretical and Practical Approach for Transdermal Drug Delivery using Microneedle for Successful Skin Penetration
Jeevan J.Mahakud, Ziaur Reheman
Department of electronics and Communication engineering, Institute of technical education and research, Bhubaneswar, Odisha, India
Department of electronics and instrumentation engineering, Institute of technical education and research, Bhubaneswar, Odisha, India
With the advent of MEMS, transdermal drug delivery has been developed to increase skin permeability for drug transport. Various microneedle structures have been analyzed theoretically as well as through simulation using COMSOL Multiphysics®. Then computational fluid dynamics has been presented in order to study the behavior of the fluid flow inside the microneedle cavity. In this report, the ...