Theoretical and Practical Approach for Transdermal Drug Delivery using Microneedle for Successful Skin Penetration
Jeevan J.Mahakud, Ziaur Reheman
Department of electronics and Communication engineering, Institute of technical education and research, Bhubaneswar, Odisha, India
Department of electronics and instrumentation engineering, Institute of technical education and research, Bhubaneswar, Odisha, India
With the advent of MEMS, transdermal drug delivery has been developed to increase skin permeability for drug transport. Various microneedle structures have been analyzed theoretically as well as through simulation using COMSOL Multiphysics®. Then computational fluid dynamics has been presented in order to study the behavior of the fluid flow inside the microneedle cavity. In this report, the ...
V. Runkana, A. Pareek, P. Arora
Tata Consultancy Services, Pune, Maharashtra, India
Indian Institute of Technology Delhi, New Delhi, Delhi, India
Limited drug efficacy, undesirable temporal changes in drug concentration and patient non-compliance due to frequent dosing schedule have given impetus to design of controlled drug release systems . Biodegradable polymers due to their favorable and tunable properties and biocompatibility have found widespread use in the field of controlled drug delivery . Exploratory in vitro experiments ...
V. Sharma , S. Pramanik , M. Mishra ,
 Indian Institute of Technology Ropar, Rupnagar, India
 Indian Institute of Technology Ropar, Rupnagar, India; Nordita, SE-10691 Stockholm, Sweden.
COMSOL Multiphysics® software was used to model radial source flow in two dimensional homogeneous porous media. Two-Phase Darcy's Law (tpdl) is used to model miscible viscous fingering. Fingering patterns obtained on using different mesh are discussed. Evolution from 'flowers' to 'branches' is observed in the fingering patterns. Stable displacement is generated even in the presence of unstable ...
B. Weber , D. Dauti , S. Dal Pont ,
 Empa, Swiss Federal Laboratories for Materials Science and Technology, Dübendorf, Switzerland
 Laboratoire 3SR, University Grenoble Alpes, Grenoble, France
When concrete is subjected to high temperature, capillary water evaporates and chemically bound water is released due to dehydration. This results in an increase of pore pressure, which is believed to be one of the mechanisms leading to spalling. Spalling of concrete is of high concern for the fire safety of concrete structures. We consider a model implemented in COMSOL® using the Weak Form ...
A. Kermani , N. Elabbasi 
 Veryst Engineering, Needham, MA, USA
Transdermal drug delivery (TDD) is used to deliver drugs through the skin as an alternative to oral, intravascular, and subcutaneous routes. While there are many advantages to TDD, skin is a very effective barrier and provides resistance to drug delivery. To improve drug delivery through the skin, permeation enhancers are used. We developed an axisymmetric COMSOL Multiphysics® software model ...
G. Zhang [1, 2, 3],
 Department of Bioengineering, Clemson University, Clemson, SC, USA
 Department of Electrical and Computer Engineering, Clemson, SC, USA
 Institute for Biological Interfaces of Engineering, Clemson University, Clemson, SC, USA
Implant devices are assistive devices surgically placed in the human body to restore the functionality of organs and tissues. Metallic implants are often used for load bearing applications including the hip and knee joints. To allow maximum flexibility during surgery for surgeons to pick and choose different combinations of parts (say, head, neck and stem, in the case of total hip replacement), ...
A.E. Varela, and J.C. García
University of Carabobo, Valencia, Venezuela
Most reactor designs are based on pseudo homogeneous models. This paper studies the COMSOL simulation of a packed bed reactor using a 2-D heterogeneous model. The case considered was a packed reactor with spherical catalyst for oxidation of o-xylene in air to phthalic anhydride. Large differences in intra-pellet temperature were found in comparison with the average temperatures resulting from ...
Migration of Mineral Oil Saturated and Aromatic Hydrocarbons(MOSH, MOAH) through Multi-Layered Packaging into Food
C. Kirse , F. Edel , H. Briesen ,
 Chair of Process Systems Engineering, Technical University of Munich, Germany
Substances like Mineral Oil Saturated Hydrocarbons (MOSH) and Mineral Oil Aromatic Hydrocarbons (MOAH) are suspected to be carcinogenic. Furthermore, MOSH/MOAH migrate through the packaging into food stuff. This work aims at modelling, how much MOSH/MOAH migrates from the packaging into food to evaluate the exposure to toxic substances. The scope of the project is not to investigate one specific ...
M.H.A. van Dongen, H.J. van Halewijn
Fontys University of Applied Sciences, Expertise Centre Thin Films & Functional Materials, Eindhoven, The Netherlands
Fontys University of Applied Sciences, Eindhoven, The Netherlands
Coalescence of droplets is a widely investigated phenomenon. In inkjet printing micrometer sized droplets are deposited on a substrate which when positioned close enough to each other will coalesce and mix. Little is known about the flows and mixing behaviour within these small droplets. In this investigation we follow the time evolved coalescence of two droplets with volume ratios ranging from ...
H. Zhu, T. Gulati, A. K. Datta, K. Huang
Institute of Applied Electromagnetics, Sichuan University, Chengdu, China
Department of Biological and Environment Engineering, Cornell University, Ithaca, NY, USA
Microwave drying of fruits and vegetables in a domestic oven has been found to result in large textural changes in the product such as puffing, crack formation and even burning due to the inhomogeneous heating of the microwaves. Microwave drying of potatoes is a complex interplay of mass, momentum and energy transport. Three phases are considered in the system: solid (skeleton), liquid (water) ...