June 9, 2022 11:00 a.m.–4:15 p.m. EDT

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COMSOL Day: Biomedical Technologies

See what is possible with multiphysics simulation

Modeling and simulation methods, such as computational fluid dynamics (CFD) and structural analysis, have been used for quite some time for the analysis of biomedical devices. Multiphysics analysis, on the other hand, is relatively new for understanding, designing, and optimizing devices and processes in biomedical technology.

Biomedical technologies encompass many different applications involving multiple coupled physical phenomena — or multiphysics, which is best described by systems of partial differential equations. These range from tumor ablation using RF waves that create localized heat sources to the electrophoretic separation of red blood cells in microfluidics applications.

COMSOL Day: Biomedical Technologies will focus on how modeling and simulation aid in designing biomedical devices and understanding the underlying physical phenomena of these devices. Parallel sessions will focus on: fluid flow and microfluidics, electromagnetics and acoustics applications, biochemical sensors, and bioheating. Experienced users from industry will present their simulation work and COMSOL engineers will hold several technical sessions throughout the day.

Schedule

11:00 a.m.
Welcoming Remarks
11:15 a.m.

This year, the global medical devices market has been valued at an estimated $450 billion USD, with a 5–6% year-on-year growth projected for the next several years. Modeling and simulation are integral to developing new and improving existing medical device designs. The best simulation software platforms for advancing medical device design are those that have built-in capabilities to handle the multiphysics phenomena that underpin the wide range of device applications.

This session will touch upon some of the key applications and physics phenomena within this industry and then focus on the workflow that can be used within a biomedical device organization to fulfill its modeling and simulation goals.

This workflow involves the three main tools for product design development within COMSOL Multiphysics®:

  • Model Builder: Functionality for building the sophisticated models used to understand, design, and optimize biomedical devices
  • Application Builder: Functionality for creating specialized apps that encapsulate full-scale models and limit user access to only a few of the model's input and output fields
  • Model Manager: A database system for managing model and app development, collaboration between different model developers and with other units of an organization, and simulation data.
11:45 a.m.
Q&A/Break
12:00 p.m.
Keynote Speaker
Electromagnetic-Based Hyperthermia Therapy for Treatment of Brain Cancer

Electromagnetic-Based Hyperthermia Therapy for Treatment of Brain Cancer

Dario Rodrigues, University of Maryland, College Park

This keynote presentation will focus on two distinct brain hyperthermia applicators close to clinical translation. One is intended for simultaneous hyperthermia (HT) and radiation (RT) treatments of brain tumor resection cavities via a thermobrachytherapy (TBT) balloon implant. The balloon is filled with nanoparticles that will be activated with an external magnetic field to induce localized heating of the resected at-risk tissue. The other is a 915 MHz annular phased-array applicator with 72 antennas designed to target brain tumors using focused and noninvasive microwave heating. Both applicators were designed and optimized in COMSOL Multiphysics® and tested in experimental head phantoms with very good agreement between the experiments and simulation results. The TBT balloon heating experiments were performed using stationary and thermal mapping probes. The microwave applicator was validated via stationary temperature and E-field probe measurements as well as magnetic resonance (MR) thermometry. Further simulations were conducted in perfused human head models, demonstrating the feasibility of heating clinically relevant targets in silico. By providing dedicated invasive and noninvasive HT brain applicators, adjuvant HT will likely significantly increase clinical outcomes of RT treatments, as it has in many other HT+RT clinical trials.

12:20 p.m.
Q&A/Break
12:30 p.m.
Parallel Session
FDA Blood Pump Validation

CFD modeling has been used extensively to simulate hemodynamics within blood-contacting medical devices. Using it in place of physical testing methods allows device developers to accelerate the development cycle, reduce costs, and validate device safety and effectiveness without exposing patients to unproven medical device prototypes.

The FDA routinely advises on using modeling and simulation to predict clinical outcomes, inform clinical trial designs, and support evidence of effectiveness. To this end, they have developed two benchmark models of the fluid flow in a nozzle and a centrifugal blood pump.

In this session, we will demonstrate a frozen rotor study based on an FDA-specified pump geometry using the CFD Module and Mixer Module add-ons to the COMSOL Multiphysics® software. In the study, a Newtonian fluid was used to describe blood flow, where a k-Ɛ turbulence model was used to obtain a good initial fluid flow solution for the shear stress transport (SST) model. We will also show how the study was validated against FDA-published benchmark data from computational studies and in vitro experiments.

Electromagnetics Applications Within Biomedical Technologies

The use of electromagnetic (EM) therapy in medical devices is not just constrained to bioheating; other applications include pacemakers, neuroscience applications such as brain, spinal nerve, and other nerve stimulation, and treating chronic pain and bladder control. Added to this list is the newly popular area of pulsed-field ablation (PFA).

COMSOL Multiphysics® provides all the tools you need to model such applications, regardless of your role in the medical device design, manufacturing, and process industry. The software caters to those modeling the underlying physics of the devices, design engineers, and even lab and field technicians and medical doctors.

This session will summarize a number of the features in COMSOL Multiphysics® and the AC/DC Module for modeling EM applications in biomedical technologies. It will also touch upon how the software can be used to create intuitive and specialized apps that can be used by all within the industry — not just modeling specialists.

1:00 p.m.
Q&A/Break
1:15 p.m.

Tech Lunches are informal sessions where you can interact with COMSOL staff and other attendees. You will be able to discuss any modeling-related topic that you like and have the opportunity to ask COMSOL technology product managers and applications engineers your questions. Join us!

1:45 p.m.
Keynote Speaker
2:05 p.m.
Q&A/Break
2:15 p.m.
Keynote Speaker
2:35 p.m.
Q&A/Break
2:45 p.m.
Parallel Session
Ultrasound and Hearing Aids in Biomedical Technologies
Biochemical Sensors and Tests
3:15 p.m.
Q&A/Break
3:30 p.m.
Parallel Session
Bioheating of Tissue
Microfluidics and Separation in Biomedical Technologies
4:00 p.m.
Q&A/Break
4:15 p.m.
Closing Remarks

COMSOL Speakers

David Kan
Vice President of Sales

David Kan is COMSOL's vice president of sales for the southwestern region of the US. He set up the Los Angeles branch office of COMSOL in 2001 and received a PhD in applied mathematics from UCLA in 1999.

Lauren Sansone
Senior Sales Events Manager

Lauren Sansone is the senior sales events manager at COMSOL, Inc. and has been with COMSOL since 2006. She is responsible for the global event marketing of COMSOL Days, the COMSOL Conference, exhibitions, and training.

Siva Sashank Tholeti
Senior Applications Engineer

Siva Sashank Tholeti is an applications engineer at COMSOL. He received his PhD in aeronautics and astronautics from Purdue University. His areas of interest include CFD, plasma-enhanced aerodynamics, plasma physics, propulsion, and multiphysics problems.

Andrew Strikwerda
Lead Application Engineer

Andrew Strikwerda is a lead application engineer at COMSOL specializing in electromagnetics. He received his PhD in physics from Boston University and conducted postgraduate research at the Technical University of Denmark. He was a senior staff scientist at the Johns Hopkins University (JHU) Applied Physics Laboratory and taught in the JHU Whiting School of Engineering.

Kirill Shaposhnikov
Senior Developer, Acoustics

Kirill Shaposhnikov works at COMSOL as a development engineer in the acoustics group. He has a degree in applied mathematics from South-Russian State Polytechnic University and a PhD in mechanical engineering from the Vienna University of Technology. His interests focus on applied mathematics, mathematical physics, and numerical analysis.

Niloofar Kamyab
Senior Applications Engineer

Niloofar Kamyab is a senior applications engineer at COMSOL with a focus on electrochemistry, including batteries and fuel cells. She received her PhD in chemical engineering from the University of South Carolina, where her research focused on the mathematical modeling of battery systems.

Jaymin Patel
Applications Engineer

Jaymin Patel is an applications engineer at COMSOL. His focus is on products related to CFD, heat transfer, and chemical engineering. He received his master's degree in chemical engineering from the Georgia Institute of Technology.

Mranal Jain
Senior Applications Engineer

Mranal Jain has been with COMSOL since 2013 and currently leads the applications team in the Los Altos, CA office. He studied microfluidics and electrokinetic transport, while pursuing his PhD in chemical engineering at the University of Alberta, Edmonton.

Phil Kinnane
Senior VP of Sales

Phil Kinnane is the senior VP of sales at COMSOL, Inc., and has been with COMSOL since 2000. Previously, he worked in industry and has modeling and simulation experience within a variety of engineering fields. He earned his PhD in electrochemical engineering from the Royal Institute of Technology (KTH), Stockholm.

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COMSOL Day Details

Local Start Time:
June 9, 2022 | 11:00 a.m. EDT (UTC-04:00)
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Invited Speakers

Dario Rodrigues University of Maryland

Dr. Dario Rodrigues is an assistant professor of thermal oncology physics and director of the Hyperthermia Therapy Practice School at the University of Maryland School of Medicine in Baltimore. He obtained his PhD in biomedical engineering from a collaboration between NOVA University Lisbon in Portugal and Duke University. Dr. Rodrigues performs adjuvant hyperthermia treatments that are combined with chemo- or radiotherapy to treat cancer patients. He also implements treatment planning, thermal dosimetry, and quality assurance of clinical microwave/radiofrequency (MW/RF) hyperthermia equipment.

His research involves the development of improved MW/RF and magnetic nanoparticle-based applicators for applying heat to tissue as well as new hyperthermia treatment planning strategies to improve thermal dose delivery. This research is accomplished with a combination of theoretical modeling, engineering development, and equipment performance evaluation with phantom, animal, and human patient subjects. His currents areas of research include MW/RF hyperthermia, mathematical modeling of multiphysics and biological systems, magnetic nanoparticle hyperthermia, MR-guided focused ultrasound, and thermal therapy treatment planning.

Dr. Rodrigues is also councilor of engineering/physics for the Society for Thermal Medicine (STM), chair of the Thermal Medicine Standards Committee hosted by the American Society of Mechanical Engineers (ASME), a member of the Institutional Review Board of the University of Maryland Baltimore, and a member of the Technical Committee of the European Society for Hyperthermic Oncology (ESHO).

Hyun-Joo Park Abbott Neuromodulation

Hyun-Joo Park is a staff research scientist at Abbott Neuromodulation. He received BS and MS degrees in control and instrumentation engineering at Seoul National University and a PhD in biomedical engineering at Case Western Reserve University. His research focus is on treating chronic pain and movement disorders with neuromodulation.