March 9, 2023 11:00 a.m.–4:00 p.m. EST

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COMSOL Day: Pharmaceutical Applications

See what is possible with multiphysics simulation

In the pharmaceutical industry, the use of COMSOL Multiphysics® modeling provides insights — particularly into biochemistry, pharmacokinetics, mixing, and separation processes — that are vital for the study of medicine, treatments, and diagnostics. The software's unique capabilities for modeling phenomena in multiple engineering fields are also useful for the design of manufacturing processes like tableting, where structural mechanics must be analyzed.

We invite you to join us at our COMSOL Day event to see how COMSOL® users in the industry can benefit from multiphysics modeling. Keynote speakers and COMSOL engineers will showcase and discuss a range of applications such as kinetics, pharmacokinetics, crystallization, membrane dialysis, multiphase flow, and solid mechanics of tablets.


11:00 a.m.

To start, we will briefly discuss the format of the day and go over the logistics for using GoToWebinar.

11:10 a.m.

In the pharmaceutical industry, the research and development of new medicines, treatments, and diagnostic devices and methods demands very high quality standards and extensive testing. Modeling and simulation provide an efficient way to gain a deeper understanding of the processes and phenomena involved and optimize said applications.

COMSOL Multiphysics® offers a wide range of descriptions of physics phenomena, which are necessary for representing the various processes that are of interest to the industry. These descriptions may be relevant for medicine manufacturing, treatment, and diagnostics, and may involve reaction kinetics and pharmacokinetics; separation processes; the modeling of sensors and rapid tests; drying, heat transfer, and heat generation; microfluidics in manufacturing and diagnostic devices; the modeling of pharmaceutical tableting; and uncertainty quantification for a better understanding of quality and safety aspects.

Join us in this session to learn about using COMSOL Multiphysics® for modeling and simulating pharmaceutical applications.

11:30 a.m.
Keynote Speaker
11:50 a.m.
12:00 p.m.
Parallel Session
Reaction Kinetics and Pharmacokinetics

Modeling of reaction engineering (RE) and physiologically-based pharmacokinetics (PK) is based on definitions of material balances for different substances in a reactor (for RE) or compartment (for PK) using ordinary differential equations (e.g., 0D time-dependent models).

The Reaction Engineering Module includes customized functionality for formulating these material balances with arbitrary kinetics for the involved chemical species (in RE) or substances (in PK). In addition, the software includes the unique ability to expand 0D reactor and compartment models to 2D and 3D geometries of real reactors and organs.

Learn more about COMSOL Multiphysics® modeling of reaction kinetics and physiologically-based pharmacokinetics in this session. We will demonstrate how to start with a 0D reactor or compartment model and expand this to a full 3D model of the reactor or organ.

Modeling of Separation Processes

Separation processes are widely used in the manufacturing of medicine, treatment devices, and diagnostic devices. These processes may include crystallization, membrane filtration and dialysis, chromatography, electrophoresis, and other separation techniques.

The COMSOL Multiphysics® modeling software is often used for efficient research and development of these processes, as it includes predefined descriptions of transport phenomena, chemical reactions, and adsorption and desorption involved in separation processes. In addition, its unique multiphysics capabilities allow for modeling of arbitrary physics phenomena coupled to transport and reaction phenomena, such as the effect of stresses and strains on porosity and the impact of electric fields on the migration of charged ions and particles.

Attend this session to learn about using COMSOL Multiphysics® to simulate a range of separation processes, from crystallization in medicine manufacturing to transport and adsorption in rapid test devices and membranes.

12:30 p.m.
12:45 p.m.
Parallel Session
Biochemical Sensors and Tests

Biochemical sensors and test devices are characterized by their bioreceptor and transducer mechanisms. Bioreceptors can be based on enzymes, antibodies, aptamers, and whole-cell receptors. Transducers can be based on electrochemical, optical, electronic, thermal, gravimetric, and acoustics methods. Modeling and simulation are key to understanding and designing these devices.

COMSOL Multiphysics® is widely used in the pharmaceutical industry for the modeling of the processes in the bioreceptors and transducers incorporated in biosensors and test devices. Its multiphysics capabilities enable the simulation of chemical reactions, diffusion and advection, fluid flow, electric and magnetic fields, thermoelectrics, bioelectrochemistry, piezoelectricity, fluid–structure interaction, optics, acoustics, and more.

Join us in this session to learn about modeling biosensors and test devices, including glucose sensors and rapid test devices, in COMSOL Multiphysics®.

Heat Transfer and Heat Generation

Heat transfer and heat generation are important processes that need to be thoroughly understood in medicine manufacturing, treatment, and diagnostics within the pharmaceutical industry.

COMSOL Multiphysics® features a wide range of capabilities for the modeling of heat transfer, heat generation, and bioheating for research and development in this industry. It can be used to optimize processes ranging from manufacturing processes such as freeze drying in powder processing to bioheat modeling in treatment devices and pharmacokinetics. The software also contains unique features for studying heat transfer and heat generation in combination with other phenomena, such as fluid flow, chemical reactions, and mechanical stresses and strains as well as electric and magnetic fields.

Join us in this session to get an overview of how COMSOL Multiphysics® can be used to model heat transfer and heat generation in pharmaceutical processes and biosystems. We will demonstrate how to define and solve heat transfer models relevant to the pharmaceutical industry.

1:15 p.m.
1:30 p.m.

Tech Lunches are informal sessions where you can interact with COMSOL staff and other attendees. You will be able to discuss any modeling-related topic that you like and have the opportunity to ask COMSOL technology product managers and applications engineers your questions. Join us!

2:00 p.m.
Keynote Speaker
2:20 p.m.
2:30 p.m.
Parallel Session
Uncertainty Quantification

Pharmaceutical processes involve many parameters that can impact the performance of a drug, treatment, or diagnostic device. The variations of these parameters result in uncertainties in the performance of processes and product quality and may introduce the risk of violating limits for safe and reliable drug use, treatment, and diagnosis.

In this session, you will learn about the different methods available in the Uncertainty Quantification Module add-on to COMSOL Multiphysics® for performing screening, sensitivity analysis of different parameters, uncertainty propagation analysis, and other types of uncertainty quantification. The Uncertainty Quantification Module quantifies risk with statistical metrics that are more informative than traditional deterministic methods. Using an example from the pharmaceutical industry, we will show you the advantages and practical uses of probabilistic methods and the Uncertainty Quantification Module.

Multiphase Flow

Simulating multiphase flow has become an important technique in the pharmaceutical industry for studying the blending or mixing and separation of powders and liquids.

COMSOL Multiphysics® features a wide range of functionality for modeling multiphase flow using both interface tracking methods and dispersed multiphase flow. In addition, the software includes unique capabilities for coupling multiphase flow with chemical species transport, electric fields, and conjugate heat transfer.

Join us in this session to find out more about the COMSOL® software's modeling capabilities for multiphase flow. Using examples including free surfaces in mixers and particle flow in cyclone separators, we will demonstrate how models are defined and solved for both interface tracking and dispersed multiphase flow methods.

3:00 p.m.
3:15 p.m.
Parallel Session

The research and development of new medicines, treatments, and diagnostics starts with having an understanding of a disease and testing potential treatment and diagnostic methods. Microfluidic devices offer the highly controlled environment needed to identify target receptors and how they are impacted by drug molecules. Similar devices are also necessary for diagnostics.

COMSOL Multiphysics® has become a go-to software for modeling and simulating microfluidic devices, such as lab-on-a-chip and rapid tests, thanks to its unique multiphysics capabilities. This includes its ability to account for electrokinetic effects, surface tension effects such as the Marangoni effect, adsorption and desorption, chemical reactions, fluid–structure interaction, and conjugate heat transfer in combination with multiphase flow in models at the microscopic scale.

Join us in this session to learn about using COMSOL Multiphysics® for microfluidics applications, including how to set up models of micromixers and blood cell separation devices as well as inkjets for droplet delivery.

Modeling Pharmaceutical Tableting Processes

Finite element analysis is commonly used in the pharmaceutical industry to study and optimize tableting processes. Such analysis can describe the powder compaction process, including phenomena such as stresses and strains in the tablets, friction, and temperature evolution during compaction and friction.

COMSOL Multiphysics® offers a wide range of powder compaction models, such as the Gurson–Tvergaard–Needleman (GTN), Fleck–Kuhn–McMeeking, Shima–Oyane, and Drucker–Prager Cap (DPC) models. These models make it possible to analyze tablet manufacturing from both low-porosity powders and high-porosity granular materials. The software also includes unique multiphysics capabilities for coupling structural mechanics models with other physics phenomena, such as heat transfer, heat generation, and moisture transport.

Attend this session to learn about using COMSOL Multiphysics® for simulating tablet production processes and see examples of how to use the GTN and DPC models for powder compaction.

3:45 p.m.
4:00 p.m.
Closing Remarks

Register for COMSOL Day: Pharmaceutical Applications

To register for the event, please create a new account or log into your existing account. You will need a COMSOL Access account to attend COMSOL Day: Pharmaceutical Applications.

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COMSOL Day Details

Local Start Time:
March 9, 2023 | 11:00 a.m. EST (UTC-05:00)
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